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Digestive pharmaceutical composition comprising S-carboxymethyl cysteine for reducing viscosity of respiratory tract secretions, and method of treating therewith

Assignee: Recherches Pharmaceutiques et Scientifiques
•
Filing: 1976-06-02
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Granted: 1977-06-07
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Expires: 1996-06-02
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Abstract

Abstract S-carboxymethyl cysteine has been proposed for administration in nasal sprays, nasal drops or aerosols in otolyaryngology and in pneumology. When administered by the digestive route, this compound has the unexpected effect of reducing the viscosity of secretions of the respiratory tract. Administration to patients may be at a level of 1.5 to 3g per day in the form of a syrup, gelatine-coated pills or capsules, tablets or suppositories, in which other active materials, e.g., antibiotics, antihistamine drugs, corticoids or bronchodilators, may also be present.

Inventors

  • 👤 Maurice L. Joullie
  • 👤 Gabriel Maillard
  • 👤 Lucien Lakah
  • 👤 Pierre Muller
  • 👤 Vu-Ngoc Huyen

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 18:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195

Claims Analysis

Total Claims: 16
Claim 1
Independent Claim 57 words
A pharmaceutical preparation in dosage unit form, adapted for administration by the digestive route for the reduction of viscosity of secretions of the respiratory tract, selected from the group consisting of a suppository, syrup, pill, capsule, or tablet and comprising, per dosage unit, an effective amount of S-carboxymethyl cysteine to accomplish said reduction, and a pharmaceutical diluent..].
Claim 2
Dependent Claim 57 words
A pharmaceutical preparation in dosage unit form, adapted for administration by the digestive route for the reduction of viscosity of secretions of the respiratory tract, selected from the group consisting of a suppository, syrup, pill, capsule, or tablet and comprising, per dosage unit, an effective amount of S-carboxymethyl cysteine to accomplish said reduction, and a pharmaceutical diluent..].
Claim 3
Dependent Claim 26 words
The preparation of claim .[.1,.]. .Iadd.19, .Iaddend.wherein said dosage unit is based upon a daily dosage of from about 1.5 to 3 grams of S-carboxymethyl cysteine.
Claim 4
Dependent Claim 10 words
A preparation of claim .[.1.]. .Iadd.19 .Iaddend.which is a suppository.
Claim 5
Dependent Claim 12 words
A preparation of claim .[.1.]. .Iadd.19 .Iaddend.which is adapted for oral administration.
Claim 6
Dependent Claim 59 words
A preparation of claim 1 which includes at least one member selected from the group consisting of antibiotics, antihistamine drugs, corticoids and bronchodilators. .[.6. A mucolytic pharmaeceutical composition, for the reduction of viscosity of secretions of the respiratory tract, in dosage unit form, comprising, per dosage unit, S-carboxymethyl cysteine (S-CMC) in a mucolytically effective amount together with a pharmaceutical
Claim 7
Dependent Claim 49 words
diluent, said pharmaceutical dosage form being an oral dosage form..]. 7. A method of reducing a viscosity of secretions of the respiratory tract, which comprises administering to a patient an effective amount of S-carboxymethyl cysteine, by the digestive route, in a form selected from the group consisting of a
Claim 8
Dependent Claim 49 words
diluent, said pharmaceutical dosage form being an oral dosage form..]. 7. A method of reducing a viscosity of secretions of the respiratory tract, which comprises administering to a patient an effective amount of S-carboxymethyl cysteine, by the digestive route, in a form selected from the group consisting of a
Claim 9
Dependent Claim 12 words
suppository, syrup, pill, capsule, or tablet. 8. The method of claim 7,
Claim 10
Dependent Claim 25 words
wherein the daily dosage is from 1.5 to 3 grams. 9. The method of claim 7, wherein the S-carboxymethyl cysteine is administered as a suppository.
Claim 11
Dependent Claim 10 words
The method of claim 7, wherein said S-carboxymethyl cysteine is
Claim 12
Dependent Claim 29 words
administered orally. 11. The method of claim 7, wherein said S-carboxymethyl cysteine is administered with at least one member selected from the group consisting of antibiotics, antihistamine drugs, corticoids
Claim 13
Dependent Claim 40 words
and bronchodilators. 12. A method of reducing the viscosity of secretions of the respiratory tract, with comprises administering to a patient an effective amount of S-carboxymethyl cysteine, by the digestive route, said effective amount being a daily dosage of at
Claim 14
Dependent Claim 40 words
and bronchodilators. 12. A method of reducing the viscosity of secretions of the respiratory tract, with comprises administering to a patient an effective amount of S-carboxymethyl cysteine, by the digestive route, said effective amount being a daily dosage of at
Claim 15
Dependent Claim 14 words
least 1.5 grams. 13. The method of claim 12, wherein the daily dosage is
Claim 16
Dependent Claim 207 words
5 to 3 grams. 14. The method of claim 12, wherein the dosage is administered orally. .Iadd. 15. The preparation of claim 19, wherein said unit dosage form is based upon a daily dosage of at least 1.5 grams. .Iaddend. .Iadd. 16. The preparation of claim 20, wherein said unit dosage form is based upon a daily dosage of at least 1.5 grams. .Iaddend. .Iadd. 17. The preparation of claim 15, containing about .2 to .5 gram per dosage unit. .Iaddend. .Iadd. 18. The preparation of claim 16, containing about .2 to .5 gram per dosage unit. .Iaddend. .Iadd. 19. A pharmaceutical preparation in dosage unit form adapted for administration by the digestive route and for the reduction of viscosity of secretions of the respiratory tract, selected from the group consisting of a suppository, syrup, pill, capsule, or tablet and comprising, per dosage unit, an effective amount of S-carboxymethyl cysteine to accomplish said reduction, and a pharmaceutical diluent. .Iaddend. .Iadd. 20. A mucolytic pharmaceutical composition for the reduction of viscosity of secretions of the respiratory tract, in dosage unit form and comprising, per dosage unit, S-carboxymethyl cysteine (S-CMC) in a mucolytically effective amount together with a pharmaceutical diluent, said pharmaceutical dosage form being an oral dosage form..Iaddend.

References Cited (Backward Citations)

FR3667E Cited
GB964989A Cited
GB1114313A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-06-06 1980-12-06 1981-06-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-06-06 1984-12-06 1985-06-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-06-06 1988-12-06 1989-06-07 $7700.00 Window Closed / Lapsed

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