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USRE29182E Expired / Lapsed US ⏱️ 0.0 years remaining

Oral composition for calculus retardation

Assignee: Procter and Gamble Co
•
Filing: 1976-06-14
•
Granted: 1977-04-12
•
Expires: 1996-06-14
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Abstract

Abstract Oral compositions, such as toothpaste, mouthwash, and the like, containing certain polyphosphonic acids and their salts which retard dental calculus formation without damaging tooth structure.

Inventors

  • 👤 Homer W. McCune
  • 👤 Nathaniel B. Tucker

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-27 17:49
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61Q; A61Q11/00

Claims Analysis

Total Claims: 22
Claim 1
Independent Claim 214 words
.[.An oral.]. .Iadd.A dentifrice .Iaddend.composition effective in inhibiting the formation of dental calculus without adversely affecting tooth structure, comprising (1) from about .01% to about 10% by weight of a polyphosphonate selected from the group consisting of those of the formulae: ##STR3##wherein R 1 and R 2 are each hydrogen or CH 2 OH; n is an integer of from 3 to 10; R 3 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, naphthyl, phenylethyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) or --CH 2 CH(PO 3 H 2 ) 2 R 4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl --CH 2 COOH, CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; or a pharmaceutically acceptable salt thereof, and (2) .[.a carrier suitable for use in the oral cavity,.]. .Iadd.from about 0.5% to 95% by weight of an abrasive material, .Iaddend.the pH of the compositon being within the range from about 5.0 to 11.0, .Iadd.said composition being free of calcium abrasives which would yield enough soluble calcium to significantly impair the anticalculus activity of said polyphosphonate. .Iaddend.
Claim 2
Dependent Claim 214 words
.[.An oral.]. .Iadd.A dentifrice .Iaddend.composition effective in inhibiting the formation of dental calculus without adversely affecting tooth structure, comprising (1) from about .01% to about 10% by weight of a polyphosphonate selected from the group consisting of those of the formulae: ##STR3##wherein R 1 and R 2 are each hydrogen or CH 2 OH; n is an integer of from 3 to 10; R 3 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, naphthyl, phenylethyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) or --CH 2 CH(PO 3 H 2 ) 2 R 4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl --CH 2 COOH, CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; or a pharmaceutically acceptable salt thereof, and (2) .[.a carrier suitable for use in the oral cavity,.]. .Iadd.from about 0.5% to 95% by weight of an abrasive material, .Iaddend.the pH of the compositon being within the range from about 5.0 to 11.0, .Iadd.said composition being free of calcium abrasives which would yield enough soluble calcium to significantly impair the anticalculus activity of said polyphosphonate. .Iaddend.
Claim 3
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethane-1-hydroxy-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is methanediphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is methanedichlorodiphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethane-1-hydroxy-1,1,2-triphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is methanehydroxydiphosphonic acid or a pharamaceutically acceptable salt thereof.
Claim 8
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is propane-1,1,3,3-tetraphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethane-2-carboxy-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethane-1,1,2-triphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethane-1-amino-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is ethanedichlorodiphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is nonane-5,5-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is n-pentane-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is methanedibromodiphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is propane-1-hydroxy-1,1,3-triphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is propane-1,2,3-triphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 18
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is butane-1,2,3,4-tetraphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim 18 words
The composition of claim 1 in which the polyphosphonate is hexane-1,2,3,4,5,6-hexaphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 20
Dependent Claim 192 words
A toothpaste composition comprising (1) from about 0.1% to about 5.0% by weight of a polyphosphonate selected from the group consisting of those of the formulae: ##STR4##wherein R 1 and R 2 are each hydrogen or CH 2 OH; n is an integer of from 3 to 10; R 3 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, naphthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) or --CH 2 CH(PO 3 H 2 ) 2 R 4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; or a pharmaceutically acceptable salt thereof, and (2) from about 20% to about 60% by weight of an abrasive material, the pH of said composition being within the range from about 7 to about 10, .Iadd.said composition being free of calcium abrasives which would yield enough soluble calcium to significantly impair the anticalculus activity of said polyphosphonate. .Iaddend.
Claim 21
Dependent Claim 192 words
A toothpaste composition comprising (1) from about 0.1% to about 5.0% by weight of a polyphosphonate selected from the group consisting of those of the formulae: ##STR4##wherein R 1 and R 2 are each hydrogen or CH 2 OH; n is an integer of from 3 to 10; R 3 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, naphthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) or --CH 2 CH(PO 3 H 2 ) 2 R 4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; or a pharmaceutically acceptable salt thereof, and (2) from about 20% to about 60% by weight of an abrasive material, the pH of said composition being within the range from about 7 to about 10, .Iadd.said composition being free of calcium abrasives which would yield enough soluble calcium to significantly impair the anticalculus activity of said polyphosphonate. .Iaddend.
Claim 22
Dependent Claim 47 words
The composition of claim 19 in which the polyphosphonate is ethane-1-hydroxy-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof. .Iadd.21. The composition of claim 19 wherein the abrasive material is selected from the group consisting of β-phase calcium pyrophosphate, thermosetting polymerized resins, alumina and insoluble non-calcium metaphosphates. .Iaddend.

References Cited (Backward Citations)

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US3213030A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-04-11 1980-10-11 1981-04-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-04-11 1984-10-11 1985-04-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-04-11 1988-10-11 1989-04-12 $7700.00 Window Closed / Lapsed

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