Patent US6920351B2 successfully refreshed from Google Patents.
US6920351B2
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Neural prosthetic using temporal structure in the local field potential
Assignee: California Institute of Technology
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Filing: 2002-11-25
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Granted: 2005-07-19
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Expires: 2022-11-25
Abstract
Abstract In an embodiment, neural activity of a subject may be measured with an implant in the sensory motor cortex of the subject and used to predict an intended movement. The measured neural activity may be the local field potential (LFP) at an electrode or single unit (SU) activity. The spectral structure of the LFP and the SU activity may be estimated using spectral analysis techniques. The estimated LFP and SU responses may be used to predict and intended movement by the subject.
Inventors
- 👤 Partha Mitra
- 👤 Bijan Pesaran
- 👤 Richard A. Andersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:21
CPC Classifications
G; G06; G06F; G06F3/00; G06F3/01; G06F3/011; G06F3/015; A; A61; A61B; A61B5/00; A61B5/24; A61B5/316; A61B5/369; A61B5/372; A61B5/374; A61F; A61F2/00; A61F2/50; A61F2/68; A61F2/70; A61F2/72; A61B5/40; A61B5/4058; A61B5/4064; A61B5/72; A61B5/7235; A61B5/7253; A61B5/726
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
49 words
A method comprising: measuring a local field potential response from neural activity in a subject; estimating a temporal structure of the measured local field potential response; and generating a signal indicative of an intended movement in response to the estimated temporal structure of said measured local field potential response.
Claim 2
Independent Claim
49 words
A method comprising: measuring a local field potential response from neural activity in a subject; estimating a temporal structure of the measured local field potential response; and generating a signal indicative of an intended movement in response to the estimated temporal structure of said measured local field potential response.
Claim 3
Dependent Claim
47 words
The method of claim 1 , further comprising: cueing a subject to perform a plurality of movements; measuring a local field potential response in response to each of said movements; and storing the local field potential response corresponding to each of said movements in a memory device.
Claim 4
Dependent Claim
38 words
The method of claim 2 , wherein generating the signal comprises: comparing the measured local field potential response to a plurality of the stored local field potential responses; and determining the intended movement in response to said comparison.
Claim 5
Dependent Claim
13 words
The method of claim 1 , wherein the signal comprises an electric signal.
Claim 6
Dependent Claim
11 words
The method of claim 1 , wherein the measuring is invasive.
Claim 7
Dependent Claim
24 words
The method of claim 1 , wherein the temporal structure of the measured local field potential response is approximately localized in time and frequency.
Claim 8
Dependent Claim
16 words
The method of claim 6 , further comprising estimating the temporal structure of using spectral analysis.
Claim 9
Dependent Claim
15 words
The method of claim 6 , wherein the temporal structure is represented as a spectrogram.
Claim 10
Dependent Claim
13 words
The method of claim 1 , wherein the intended movement comprises a reach.
Claim 11
Dependent Claim
11 words
The method of claim 9 , wherein the reach comprises target.
Claim 12
Dependent Claim
11 words
The method of claim 9 , wherein the reach comprises trajectory.
Claim 13
Dependent Claim
13 words
The method of claim 9 , wherein the intended movement comprises a grasp.
Claim 14
Dependent Claim
13 words
The method of claim 1 , wherein the intended movement comprises a saccade.
Claim 15
Dependent Claim
14 words
The method of claim 1 , wherein the intended movement comprises a head movement.
Claim 16
Dependent Claim
16 words
The method of claim 1 , wherein the intended movement comprises a smooth pursuit eye movement.
Claim 17
Dependent Claim
14 words
The method of claim 1 , wherein the intended movement comprises a leg movement.
Claim 18
Dependent Claim
14 words
The method of claim 1 , wherein the intended movement comprises a go signal.
Claim 19
Dependent Claim
14 words
The method of claim 1 , wherein the intended movement comprises a scrub signal.
Claim 20
Dependent Claim
17 words
The method of claim 1 , wherein the neural activity comprises activity in the sensory motor cortex.
Claim 21
Dependent Claim
17 words
The method of claim 1 , wherein the neural activity comprises activity in the parietal reach region.
Claim 22
Dependent Claim
17 words
The method of claim 1 , wherein the neural activity comprises activity in the anterior intraparietal cortex.
Claim 23
Dependent Claim
17 words
The method of claim 1 , wherein the neural activity comprises activity in the lateral intraparietal cortex.
Claim 24
Dependent Claim
20 words
The method of claim 1 , wherein the neural activity comprises activity in area 5 of the superior parietal lobule.
Claim 25
Dependent Claim
52 words
The method of claim 1 , wherein the neural activity comprises activity in frontal cortical areas involved in movement, said area selected from the motor cortex, the ventral and dorsal premotor cortex, the supplementary motor area, the supplementary eye field, the frontal eye field, the prefrontal cortex, and the pre-supplementary motor area.
Claim 26
Dependent Claim
17 words
The method of claim 1 , wherein the neural activity comprises activity in the ventral intraparietal cortex.
Claim 27
Dependent Claim
18 words
The method of claim 1 , wherein the neural activity comprises activity in the medial superior temporal cortex.
Claim 28
Dependent Claim
22 words
The method of claim 1 , further comprising decoding a direction in a gamma frequency band of the local field potential response.
Claim 29
Dependent Claim
32 words
The method of claim 1 , further comprising decoding a logical signal in at least one of a gamma frequency band and a beta frequency band of the local field potential response.
Claim 30
Dependent Claim
14 words
The method of claim 28 , wherein the logical signal comprises a “go” signal.
Claim 31
Dependent Claim
41 words
The method of claim 1 , further comprising measuring spike response having a temporal structure approximately localized in time and frequency, and wherein the signal is generated in response to the measured local field potential response and the measured spike response.
Claim 32
Independent Claim
40 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises sorted spiking activity.
Claim 33
Independent Claim
40 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises sorted spiking activity.
Claim 34
Independent Claim
42 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises measuring a local field potential.
Claim 35
Independent Claim
42 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises measuring a local field potential.
Claim 36
Independent Claim
40 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises unsorted spiking activity.
Claim 37
Independent Claim
40 words
A method comprising: measuring neural activity; analyzing a time and Fourier frequency localized representation of the neural activity; and generating a signal indicative of an intended movement in response to said analysis, wherein the neural activity comprises unsorted spiking activity.
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