US6721582B2
Expired / Lapsed
US
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Non-invasive tissue glucose level monitoring
Assignee: General Hospital Corp
•
Filing: 2001-02-20
•
Granted: 2004-04-13
•
Expires: 2021-02-20
Abstract
Abstract Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
Inventors
- 👤 Pierre Trepagnier
- 👤 Jenny Freeman
- 👤 James Mansfield
- 👤 Derek Brand
- 👤 Michael J. Hopmeier
- 👤 Nikiforos Kollias
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 12:59
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0059; A61B5/0062; A61B5/0071; A61B5/145; A61B5/14532; A61B5/1455; A61B5/44; A61B5/441; A61B5/443; A61B5/444; A61B5/445
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
186 words
A non-invasive glucose monitoring instrument comprising: a radiation source for directing excitation radiation to a portion of a tissue surface wherein said source emits excitation radiation at a plurality of different wavelengths of ultraviolet or visible light that excites a target to emit radiation, such that the radiation emitted from the excited target and received at the tissue surface correlates with a glucose level of the tissue; a radiation detector positioned to receive the radiation emitted from the tissue surface, wherein the radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation; and analyzing means operatively connected to the radiation detector for analyzing radiation detected by the radiation detector and translating said detected radiation to an indication of the tissue glucose level, wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD a flavoprotein, and any combination thereof.
Claim 2
Dependent Claim
186 words
A non-invasive glucose monitoring instrument comprising: a radiation source for directing excitation radiation to a portion of a tissue surface wherein said source emits excitation radiation at a plurality of different wavelengths of ultraviolet or visible light that excites a target to emit radiation, such that the radiation emitted from the excited target and received at the tissue surface correlates with a glucose level of the tissue; a radiation detector positioned to receive the radiation emitted from the tissue surface, wherein the radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation; and analyzing means operatively connected to the radiation detector for analyzing radiation detected by the radiation detector and translating said detected radiation to an indication of the tissue glucose level, wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD a flavoprotein, and any combination thereof.
Claim 3
Dependent Claim
11 words
The instrument of claim 1 which comprises a sync 50 scan.
Claim 4
Dependent Claim
11 words
The instrument of claim 1 which comprises an excitation emission map.
Claim 5
Dependent Claim
16 words
The instrument of claim 1 where the included excitation wavelengths excite 370 nm and 460 nm.
Claim 6
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 285 and 305 nm and the radiation detector is operative to detect radiation at between about 315 and 420 nm.
Claim 7
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 330 and 345 nm and the radiation detector is operative to detect radiation at between about 370 and 410 nm.
Claim 8
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 330 and 360 nm and the radiation detector is operative to detect radiation at between about 400 and 550 nm.
Claim 9
Dependent Claim
37 words
The instrument of claim 1 wherein the radiation source is operative to emit radiation at between about 330 and 500 nm and the radiation detector is operative to detect radiation at between about 500 and 560 nm.
Claim 10
Dependent Claim
28 words
The instrument of claim 1 further comprising a normalizing detector responsive to another target that provides normalizing information to said processing circuit to normalize the indicated glucose level.
Claim 11
Dependent Claim
23 words
The instrument of claim 1 further comprising normalizing means which provides normalizing information to said analyzing means to normalize the indicated glucose level.
Claim 12
Dependent Claim
23 words
The instrument of claim 10 wherein said normalizing means normalizes for age, UV damage, skin color, temperature, perfusion, hydration, pH and combinations thereof.
Claim 13
Dependent Claim
87 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at two wavelengths of about 370 and 460 nm.
Claim 14
Dependent Claim
87 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at two wavelengths of about 370 and 460 nm.
Claim 15
Dependent Claim
85 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at a wavelength of about 590 nm.
Claim 16
Dependent Claim
85 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at a wavelength of about 590 nm.
Claim 17
Dependent Claim
85 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at a wavelength of about 670-680 nm.
Claim 18
Dependent Claim
85 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at a wavelength of about 670-680 nm.
Claim 19
Dependent Claim
87 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at two wavelengths of about 740 and 920 nm.
Claim 20
Dependent Claim
87 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is at two wavelengths of about 740 and 920 nm.
Claim 21
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is a combination of subsets of the region of 280-1,100 nm.
Claim 22
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the excitation radiation is a combination of subsets of the region of 280-1,100 nm.
Claim 23
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 340 and 400 nm.
Claim 24
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 340 and 400 nm.
Claim 25
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 400 and 550 nm.
Claim 26
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 400 and 550 nm.
Claim 27
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 500 and 560 nm.
Claim 28
Dependent Claim
88 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is between about 500 and 560 nm.
Claim 29
Dependent Claim
92 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is a combination of subsets of the region of 340-560 nm.
Claim 30
Dependent Claim
92 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the radiation detected from the excited target is a combination of subsets of the region of 340-560 nm.
Claim 31
Dependent Claim
82 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, the method further comprising normalizing the glucose level determined.
Claim 32
Dependent Claim
82 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, the method further comprising normalizing the glucose level determined.
Claim 33
Dependent Claim
33 words
The method of claim 21 wherein normalizing comprises normalizing for one or more variables selected from the group consisting of temperature, degree of perfusion, age, UV damage, skin color temperature, hydration, and pH.
Claim 34
Dependent Claim
86 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, the method further comprising measuring scattering and absorbance and adjusting the glucose level.
Claim 35
Dependent Claim
86 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, the method further comprising measuring scattering and absorbance and adjusting the glucose level.
Claim 36
Dependent Claim
108 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein said step of determining the glucose level comprises analyzing the radiation detected using one or more multi variate analysis methodologies selected from a group comprising PLS, PCR, LDA, MLR, stepwise LR and combinations thereof.
Claim 37
Dependent Claim
108 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein said step of determining the glucose level comprises analyzing the radiation detected using one or more multi variate analysis methodologies selected from a group comprising PLS, PCR, LDA, MLR, stepwise LR and combinations thereof.
Claim 38
Dependent Claim
108 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein said step of exciting comprises irradiating a target with excitation radiation at a plurality of wavelengths and the step of detecting radiation comprises the step of synchronously scanning the emitted radiation and excitation radiation.
Claim 39
Dependent Claim
108 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein said step of exciting comprises irradiating a target with excitation radiation at a plurality of wavelengths and the step of detecting radiation comprises the step of synchronously scanning the emitted radiation and excitation radiation.
Claim 40
Dependent Claim
106 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the step of exciting comprises application of a probe to the skin, said probe comprising a radiation source and, wherein a position of the probe on the skin is varied during detecting.
Claim 41
Dependent Claim
106 words
A non-invasive method of detecting a glucose level of a tissue comprising: exciting a non-glucose target in the tissue with ultraviolet radiation or visible light wherein the excited target emits radiation such that the radiation received at a tissue surface is indicative of a glucose level of a patient; detecting radiation emitted by the target and transmitted through the intervening tissue to the surface; and determining said glucose level from the radiation detected, wherein the step of exciting comprises application of a probe to the skin, said probe comprising a radiation source and, wherein a position of the probe on the skin is varied during detecting.
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