US6709425B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular inducing implants
Assignee: CR Bard Inc
•
Filing: 2001-01-31
•
Granted: 2004-03-23
•
Expires: 2021-01-31
Abstract
Abstract Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.
Inventors
- 👤 Richard A. Gambale
- 👤 Stephen J. Forcucci
- 👤 Michael F. Weiser
- 👤 Richard T. Choh
- 👤 Sean Forde
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:24
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/94; A61B; A61B17/00; A61B17/00234; A61F2/02; A61F2/04; A61F2/06; A61F2/24; A61F2/2493; A61B2017/00238; A61B2017/00243; A61F2220/00; A61F2220/0008; A61F2220/0016; A61F2220/0025; A61F2220/005; A61F2220/0058; A61F2230/00; A61F2230/0063; A61F2230/0073; A61F2230/0076; A61F2230/0091; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
60 words
A method of promoting angiogenesis in ischemic tissue comprising the steps of: providing an implant, associating an angiogenic substance with the implant, accessing the ischemic tissue, inserting the implant into the tissue, orienting the implant in the tissue to place the tissue in stress by expanding the implant from a low profile first configuration to a large profile second configuration.
Claim 2
Independent Claim
60 words
A method of promoting angiogenesis in ischemic tissue comprising the steps of: providing an implant, associating an angiogenic substance with the implant, accessing the ischemic tissue, inserting the implant into the tissue, orienting the implant in the tissue to place the tissue in stress by expanding the implant from a low profile first configuration to a large profile second configuration.
Claim 3
Dependent Claim
26 words
A method of promoting angiogenesis as defined in claim 1 comprising the further step of associating a angiogenic substance with the device after it is implanted.
Claim 4
Dependent Claim
26 words
A method of promoting angiogenesis as defined in claim 1 wherein the implant comprises a body having an interior containing an angiogenic substance to promote angiogenesis.
Claim 5
Dependent Claim
33 words
A method of promoting angiogenesis in ischemic tissue as defined in claim 1 further comprising: irritating the tissue sufficiently to cause an injury response in the tissue that includes thrombosis and initiates angiogenesis.
Claim 6
Dependent Claim
25 words
A method of promoting angiogenesis as defined in claim 4 wherein the tissue irritation is caused by the presence of a implant in the tissue.
Claim 7
Dependent Claim
18 words
A method as defined in claim 5 wherein the implants are implanted entirely and only within the myocardium.
Claim 8
Dependent Claim
16 words
A method of promoting angiogenesis as defined in claim 5 wherein the tissue is myocardial tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-03-23 | 2007-09-22 | 2008-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-03-23 | 2011-09-22 | 2012-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-03-23 | 2015-09-22 | 2016-03-23 | $7700.00 | Window Closed / Lapsed |