US6689086B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of using a catheter for delivery of ultrasonic energy and medicament
Assignee: Abbott Cardiovascular Systems Inc
•
Filing: 1999-07-29
•
Granted: 2004-02-10
•
Expires: 2019-07-29
Abstract
Abstract An ultrasound delivery catheter equipped and configured for concurrent delivery of drugs or therapeutic agents. The catheter comprises an elongate pliable catheter body having an ultrasound delivery member or wire extending longitudinally therethrough. A drug/therapeutic agent infusion lumen also extends longitudinally through the body of the catheter and opens distally through one or more outflow apertures at or near the distal end of the catheter body. The drug/therapeutic agent outflow apertures are preferably positioned and configured to cause the drug or therapeutic agent to flow in direction(s) non-parallel to the longitudinal axis of the catheter. The delivery of ultrasound through the catheter, concurrent with infusion of drug or therapeutic agent therethrough, will cause the drug or therapeutic agent to be disseminated or dispersed by the ultrasonic vibration or movement at the distal end of the catheter.
Inventors
- 👤 Henry Nita
- 👤 Timothy Mills
- 👤 Robert Siegel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:36
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B17/22012; A61B2017/22014; A61B2017/22082; A61B2017/22084
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
268 words
A method for ultrasonic ablation of matter from an anatomical passageway of a mammalian body and for concomitant delivery of a liquid medicament, said method comprising the steps of: inserting into the mammalian body distal end first an ultrasound delivery/medicament infusion catheter comprising an elongate flexible catheter body having a longitudinal axis, a proximal end and a distal end, a distal tip member attached to the distal end of the catheter body, an ultrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction to be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency which will result in ablation of said obstruction; and passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member concurrently with the delivery of said ultrasonic energy through said catheter.
Claim 2
Independent Claim
268 words
A method for ultrasonic ablation of matter from an anatomical passageway of a mammalian body and for concomitant delivery of a liquid medicament, said method comprising the steps of: inserting into the mammalian body distal end first an ultrasound delivery/medicament infusion catheter comprising an elongate flexible catheter body having a longitudinal axis, a proximal end and a distal end, a distal tip member attached to the distal end of the catheter body, an ultrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction to be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency which will result in ablation of said obstruction; and passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member concurrently with the delivery of said ultrasonic energy through said catheter.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the step of passing a flow of medicament further comprises: delivering a thrombolytic agent through said catheter.
Claim 4
Dependent Claim
25 words
The method of claim 2 wherein said thrombolytic agent is selected from the group consisting of: streptokinase; urokinase; tissue plasminogen activator; and possible combinations thereof.
Claim 5
Dependent Claim
22 words
The method of claim 1 wherein the step of passing a flow of medicament comprises: delivering an anticoagulant agent through said catheter.
Claim 6
Dependent Claim
11 words
The method of claim 4 wherein said anticoagulant agent is heparin.
Claim 7
Independent Claim
278 words
A method for ultrasonic ablation of matter from an anatomical passageway of a mammalian body and for concomitant delivery of a liquid medicament, said method comprising the steps of: inserting into the mammalian body distal end first an ultrasound delivery/medicament infusion catheter comprising an elongate flexible catheter body having a longitudinal axis, a proximal end and a distal end, a distal tip member attached to the distal end of the catheter body, an ultrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member; and passing sufficient ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter concurrently with the delivery of said medicament through said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency that will result in ablation of said obstruction and that will result in the thorough dissemination of said medicament.
Claim 8
Independent Claim
278 words
A method for ultrasonic ablation of matter from an anatomical passageway of a mammalian body and for concomitant delivery of a liquid medicament, said method comprising the steps of: inserting into the mammalian body distal end first an ultrasound delivery/medicament infusion catheter comprising an elongate flexible catheter body having a longitudinal axis, a proximal end and a distal end, a distal tip member attached to the distal end of the catheter body, an ultrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member; and passing sufficient ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter concurrently with the delivery of said medicament through said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency that will result in ablation of said obstruction and that will result in the thorough dissemination of said medicament.
Claim 9
Dependent Claim
50 words
The method of claim 6 wherein the step of passing ultrasonic energy through said ultrasound transmission member comprises passing sufficient ultrasonic energy to the distal tip member at the distal end of said catheter such that the medicament effectiveness upon adjacent tissue acted upon by the ultrasonic energy is improved.
References Cited (Backward Citations)
US3433226A
Cited
US3352303A
Cited
US3526219A
Cited
US3589363A
Cited
US3565062A
Cited
US3618594A
Cited
US3809093A
Cited
US3823717A
Cited
US3861391A
Cited
US3896811A
Cited
DE2453126A1
Cited
DE2349120A1
Cited
DE2438648A1
Cited
DE2453058A1
Cited
DE2541919A1
Cited
DE2703486A1
Cited
GB1531659A
Cited
US4223676A
Cited
FR2424733A1
Cited
US4214586A
Cited
US4366819A
Cited
DE8119209U1
Cited
US4800876A
Cited
US4800876B1
Cited
US4431006A
Cited
US4587958A
Cited
US4692139A
Cited
US4587972A
Cited
US4960411A
Cited
US4589419A
Cited
EP0189329A2
Cited
EP0208175A2
Cited
US4750902A
Cited
WO1987001276A1
Cited
US4957111A
Cited
EP0234951A1
Cited
US4794931A
Cited
DE3707567A1
Cited
DE3707921A1
Cited
WO1987005793A1
Cited
US4821731A
Cited
US4808153A
Cited
EP0293472A1
Cited
US5058570A
Cited
US4988356A
Cited
US4967653A
Cited
US4841977A
Cited
US4799496A
Cited
GB2208138A
Cited
DE3826414A1
Cited
US4898575A
Cited
US4784638A
Cited
EP0315290A1
Cited
US4917097A
Cited
GB2212267A
Cited
US4870953A
Cited
EP0316796A2
Cited
WO1989005123A1
Cited
WO1989006515A1
Cited
WO1989007419A1
Cited
US4844092A
Cited
DE3812836A1
Cited
US4924863A
Cited
EP0347098A2
Cited
US4920954A
Cited
WO1990001300A1
Cited
US4919133A
Cited
WO1990007303A1
Cited
FR2641693A3
Cited
FR2643272A1
Cited
US4923441A
Cited
US4936281A
Cited
WO1991002489A1
Cited
WO1991010403A1
Cited
EP0443256A1
Cited
US5069664A
Cited
US5328471A
Cited
WO1991014401A1
Cited
EP0472368A2
Cited
US5267954A
Cited
US5312328A
Cited
US5397301A
Cited
US5498236A
Cited
US5382228A
Cited
US5362309A
Cited
US6287271B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-02-09 | 2007-08-11 | 2008-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-02-09 | 2011-08-11 | 2012-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-02-09 | 2015-08-11 | 2016-02-10 | $7700.00 | Window Closed / Lapsed |