US6599520B2
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Method of inducing new bone growth in porous bone sites
Assignee: Warsaw Orthopedic Inc
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Filing: 2002-03-14
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Granted: 2003-07-29
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Expires: 2022-03-14
Abstract
Abstract A method of treating a condition in a vertebrate animal characterized by bone having increased porosity and/or decreased bone mineral density. The porous bone is injected with an effective amount of a flowable bone composition. Also provided is a kit for the treatment of porous bone wherein a flowable bone composition is contained within an injectable delivery system.
Inventors
- 👤 Nelson L. Scarborough
- 👤 James Russell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:57
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/70; A61B17/7061; A61L24/00; A61L24/0005; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3654; A61F; A61F2/00; A61F2/02; A61F2/28; A61L2430/00; A61L2430/38
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
52 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone.
Claim 2
Independent Claim
52 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone.
Claim 3
Dependent Claim
32 words
The method of claim 1 wherein the trabecular bone is selected from the group consisting of vertebrae, rib, clavicle, sternum, femoral neck, hip, wrist and the distal ends of the long bones.
Claim 4
Dependent Claim
37 words
The method of claim 1 wherein the condition is selected from the group consisting of osteoporosis, osteomalacia, osteitis fibrosa, Paget's disease, bone deficiency, primary or secondary hyperparathyroidism, chronic inflammatory conditions, metastatic bone disease and osteolytic bone disease.
Claim 5
Dependent Claim
50 words
The method of claim 3 wherein the condition of osteoporosis is selected from the group consisting of age-related osteoporosis, post-menopausal osteoporosis, juvenile osteoporosis, Cushing's syndrome osteoporosis, multiple myeloma osteoporosis, leukemia osteoporosis, Turner's syndrome osteoporosis, alcohol osteoporosis, chronic liver disease osteoporosis, glucocorticoid-induced osteoporosis, chronic inflammatory disease induced osteoporosis and disuse osteoporosis.
Claim 6
Dependent Claim
23 words
The method of claim 1 further comprising administering to the animal one or more agents that promote bone growth and/or inhibit bone resorption.
Claim 7
Dependent Claim
33 words
The method of claim 5 wherein the agent(s) is selected from the group consisting of bone morphogenetic factors, anti-resorption agents, osteogenic factors, cartilage-derived morphogenetic proteins, hormones, growth hormones, genetic material and differentiating factors.
Claim 8
Independent Claim
39 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone.
Claim 9
Independent Claim
39 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone.
Claim 10
Dependent Claim
31 words
The method of claim 7 wherein the bone is selected from the group consisting of vertebrae, rib, clavicle, sternum, femoral neck, hip, wrist and the distal ends of the long bones.
Claim 11
Dependent Claim
23 words
The method of claim 7 further comprising administering to the animal one or more agents that promote bone growth and/or inhibit bone resorption.
Claim 12
Dependent Claim
33 words
The method of claim 9 wherein the agent(s) is selected from the group consisting of bone morphogenetic factors, anti-resorption agents, osteogenic factors, cartilage-derived morphogenetic proteins, hormones, growth hormones, genetic material and differentiating factors.
Claim 13
Dependent Claim
26 words
The method of claim 1 wherein the bone is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 14
Dependent Claim
29 words
The method of claim 11 wherein the bone particles are selected from the group consisting of mineralized bone particles, partially demineralized bone particles, demineralized bone particles and combinations thereof.
Claim 15
Dependent Claim
23 words
The method of claim 1 wherein the flowable bone composition includes a biocompatible liquid material as carrier or suspension agent for the bone.
Claim 16
Dependent Claim
15 words
The method of claim 13 wherein the biocompatible liquid material is glycerol or glycerol solution.
Claim 17
Dependent Claim
26 words
The method of claim 7 wherein the bone is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 18
Dependent Claim
29 words
The method of claim 15 wherein the bone particles are selected from the group consisting of mineralized bone particles, partially demineralized bone particles, demineralized bone particles and combinations thereof.
Claim 19
Dependent Claim
23 words
The method of claim 7 wherein the flowable bone composition includes a biocompatible liquid material as carrier or suspension agent for the bone.
Claim 20
Dependent Claim
15 words
The method of claim 17 wherein the biocompatible liquid material is glycerol or glycerol solution.
Claim 21
Independent Claim
74 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of cortical bone and trabecular bone selected from the group consisting of vertebrae, rib, clavicle, sternum, femoral neck, hip, wrist and the distal ends of the long bones.
Claim 22
Independent Claim
74 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of cortical bone and trabecular bone selected from the group consisting of vertebrae, rib, clavicle, sternum, femoral neck, hip, wrist and the distal ends of the long bones.
Claim 23
Independent Claim
75 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 24
Independent Claim
75 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 25
Dependent Claim
29 words
The method of claim 20 wherein the bone particles are selected from the group consisting of mineralized bone particles, partially demineralized bone particles, demineralized bone particles and combinations thereof.
Claim 26
Independent Claim
82 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition includes a biocompatible liquid material selected from the group consisting of glycerol and glycerol solution as carrier or suspension agent for the flowable bone composition.
Claim 27
Independent Claim
82 words
A method of treating a condition in a vertebrate animal, the condition characterized by a bone having increased porosity and/or decreased bone mineral density, which comprises injecting the bone with an effective amount of a flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition includes a biocompatible liquid material selected from the group consisting of glycerol and glycerol solution as carrier or suspension agent for the flowable bone composition.
Claim 28
Independent Claim
62 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 29
Independent Claim
62 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition is provided as a mass of particles ranging in average size from about 0.1 to about 1.2 cm.
Claim 30
Dependent Claim
29 words
The method of claim 23 wherein the bone particles are selected from the group consisting of mineralized bone particles, partially demineralized bone particles, demineralized bone particles and combinations thereof.
Claim 31
Independent Claim
69 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition includes a biocompatible liquid material selected from the group consisting of glycerol and glycerol solution as carrier or suspension agent for the flowable bone composition.
Claim 32
Independent Claim
69 words
A method of vertebroplasty which comprises injecting a vertebra having increased porosity and/or decreased bone mineral density with an effective amount of flowable bone composition, the bone being selected from the group consisting of trabecular bone and cortical bone, wherein the flowable bone composition includes a biocompatible liquid material selected from the group consisting of glycerol and glycerol solution as carrier or suspension agent for the flowable bone composition.
References Cited (Backward Citations)
US5922753A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-07-28 | 2007-01-27 | 2007-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-07-28 | 2011-01-27 | 2011-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-07-28 | 2015-01-27 | 2015-07-29 | $7700.00 | Window Closed / Lapsed |