US5922753A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for treating bone deficit conditions with benzothiazole
Assignee: OsteoScreen Inc
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Filing: 1997-02-28
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Granted: 1999-07-13
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Expires: 2017-02-28
Abstract
Abstract Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
Inventors
- 👤 Charles Petrie
- 👤 Mark W. Orme
- 👤 Nand Baindur
- 👤 Kirk G. Robbins
- 👤 Laurence H. Hurley
- 👤 Sean M. Kerwin
- 👤 Gregory R. Mundy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/428; A61K31/4164; A61K31/4184
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
84 words
A method to treat a condition in a vertebrate animal characterized by a deficiency in, or need for, bone growth replacement and/or an undesirable level of bone resorption, which method comprises administering to a vertebrate subject in need of such treatment an effective amount of a compound of the formula: ##STR5## wherein each R 1 and R 2 is independently a non-interfering substituent; m is an integer of 0-4; the dotted line represents an optional π bond; and L is a flexible non-conjugating linker.
Claim 2
Independent Claim
84 words
A method to treat a condition in a vertebrate animal characterized by a deficiency in, or need for, bone growth replacement and/or an undesirable level of bone resorption, which method comprises administering to a vertebrate subject in need of such treatment an effective amount of a compound of the formula: ##STR5## wherein each R 1 and R 2 is independently a non-interfering substituent; m is an integer of 0-4; the dotted line represents an optional π bond; and L is a flexible non-conjugating linker.
Claim 3
Dependent Claim
24 words
The method of claim 1 wherein L is selected from the group consisting of --NRCO-- and --CONR--, wherein R is H or alkyl (1-6C).
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein R 2 is --NR 2 or --OR where each R is independently H or alkyl (1-6C).
Claim 5
Dependent Claim
20 words
The method of claim 1 wherein said compound is selected from the group consisting of Compound Nos. 59-0102 and 59-0070.
Claim 6
Dependent Claim
36 words
The method of claim 1 wherein said condition is osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, or post-dental implantation.
Claim 7
Dependent Claim
25 words
The method of claim 1 which further comprises administering to said subject one or more agents that promote bone growth or that inhibit bone resorption.
Claim 8
Dependent Claim
30 words
The method of claim 6 wherein said agents are selected from the group consisting of bone morphogenetic factors, anti-resorptive agents, osteogenic factors, cartilage-derived morphogenic proteins, growth hormones, and differentiating factors.
References Cited (Backward Citations)
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Cited
US5280040A
Cited
WO1995010513A1
Cited
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Cited
US5523309A
Cited
US5622974A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-07-12 | 2003-01-11 | 2003-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-12 | 2007-01-11 | 2007-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-12 | 2011-01-11 | 2011-07-13 | $7700.00 | Window Closed / Lapsed |