Patent US6547787B1 successfully refreshed from Google Patents.
US6547787B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery catheters that attach to tissue and methods for their use
Assignee: Biocardia Inc
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Filing: 1999-10-13
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Granted: 2003-04-15
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Expires: 2019-10-13
Abstract
Abstract A drug delivery catheter suited for cardiac procedures including transmyocardial revascularization. The catheter includes a distal helical coil or other fixation and penetrating element, which can be operated from the proximal end of the catheter to engage and penetrate the myocardium. Once delivered to the inside of the heart, the catheter can be used to created several helical wounds in the myocardium, and also inject small doses of therapeutic agents to the wounds. The TMR accomplished by the procedure provides for large wound to penetration ratio, and limits the potential of perforating the heart wall.
Inventors
- 👤 Peter A. Altman
- 👤 Brian Hakem
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:48
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/1492; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/14; A61K9/16; A61K9/167; A61K9/1676; A61K9/48; A61K9/50; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056; A61N1/057; A61N1/0573; A61N1/0575; A61B17/00; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B2017/00247; A61B2018/00005; A61B2018/00011; A61B2018/00315; A61B2018/00345; A61B2018/00351; A61B2018/00392; A61B2018/00571; A61B2018/00577; A61B2018/00636; A61B2018/00773; A61B2018/00839; A61B2018/1405; A61B2018/1425; A61B2018/1435; A61B2218/00; A61B2218/001; A61B2218/002; A61M; A61M25/00; A61M25/0067; A61M25/0082; A61M25/0084; A61M2025/0089
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
88 words
A method of treating a human heart by performing transmyocardial revascularization and penetrating the heart wall, said method comprising: providing a catheter having a distal end adapted for percutaneous insertion into the patient's body and further manipulation into the heart of the patient; providing a helical penetrating structure on the distal tip of the catheter; inserting the distal end of the catheter into the endocardial space of the heart; and penetrating the heart wall with the helical penetrating structure at a plurality of sites on the heart wall.
Claim 2
Independent Claim
88 words
A method of treating a human heart by performing transmyocardial revascularization and penetrating the heart wall, said method comprising: providing a catheter having a distal end adapted for percutaneous insertion into the patient's body and further manipulation into the heart of the patient; providing a helical penetrating structure on the distal tip of the catheter; inserting the distal end of the catheter into the endocardial space of the heart; and penetrating the heart wall with the helical penetrating structure at a plurality of sites on the heart wall.
Claim 3
Dependent Claim
117 words
The method of claim 1 further comprising: providing a fluid delivery lumen in the helical penetrating structure and a fluid delivery lumen in the catheter communicating from the proximal end of the catheter to the fluid delivery lumen of the helical penetrating structure; delivering a contrast agent through the fluid delivery lumen of the catheter and the fluid delivery lumen of the helical penetrating structure into the heart wall; confirming that the helical penetrating structure has been screwed into the heart wall to a desired depth by viewing the heart under fluoroscopy; delivering therapeutic agent through the fluid delivery lumen of the catheter and the fluid delivery lumen of the helical penetrating structure into the heart wall.
Claim 4
Dependent Claim
70 words
The method of claim 2 further comprising: repeating the steps of penetrating the heart wall, injecting contrast agent through the fluid delivery lumen, and removing the helical penetrating element from the heart wall; prior to each repetition of the penetrating step in a subsequent penetration site, viewing the heart under fluoroscopy and identifying prior penetration sites and sites not yet penetrated to assist in selection of the subsequent penetration site.
Claim 5
Independent Claim
103 words
A method of treating a human heart by performing transmyocardial revascularization and penetrating the heart wall, said method comprising: providing a catheter having a distal end adapted for percutaneous insertion into the patient's body and further manipulation into the heart of the patient; providing a helical penetrating structure on the distal tip of the catheter; inserting the distal end of the catheter into the endocardial space of the heart; and penetrating the heart wall with the helical penetrating element by manipulating the helical penetrating element to engage the heart wall and rotating the helical penetrating element to screw it into the heart wall.
Claim 6
Independent Claim
103 words
A method of treating a human heart by performing transmyocardial revascularization and penetrating the heart wall, said method comprising: providing a catheter having a distal end adapted for percutaneous insertion into the patient's body and further manipulation into the heart of the patient; providing a helical penetrating structure on the distal tip of the catheter; inserting the distal end of the catheter into the endocardial space of the heart; and penetrating the heart wall with the helical penetrating element by manipulating the helical penetrating element to engage the heart wall and rotating the helical penetrating element to screw it into the heart wall.
Claim 7
Dependent Claim
62 words
The method of claim 4 further comprising the steps of: repeatedly manipulating the helical penetrating element to engage the heart wall and rotating the helical penetrating element to screw it into the heart wall, and removing the helical penetrating element from the heart wall until a region of the heart wall has been wounded with helical wounds from the helical penetrating element.
Claim 8
Independent Claim
31 words
The method of clay further comprising: screwing the helical penetrating structure into the heart to advanced the helical penetrating structure from about 4 to about 50 turns into the heart wall.
Claim 9
Independent Claim
31 words
The method of clay further comprising: screwing the helical penetrating structure into the heart to advanced the helical penetrating structure from about 4 to about 50 turns into the heart wall.
Claim 10
Dependent Claim
69 words
The method of claim 4 further comprising: providing a fluid delivery lumen in the helical penetrating structure and a fluid delivery lumen in the catheter communicating from the proximal end of the catheter to the fluid delivery lumen of the helical penetrating structure; delivering a therapeutic agent through the fluid delivery lumen of the catheter and the fluid delivery lumen of the helical penetrating structure into the heart wall.
Claim 11
Dependent Claim
59 words
The method of claim 7 further comprising the steps of: maintaining the helical penetrating structure screwed into the heart wall after delivery of therapeutic agent through the helical penetrating structure for a time sufficient to impede outflow of therapeutic agent from the helical wound caused by penetration of the helical penetrating structure after removal of the helical penetrating structure.
Claim 12
Dependent Claim
62 words
The method of claim 7 further comprising the steps of: repeatedly manipulating the helical penetrating element to engage the heart wall and rotating the helical penetrating element to screw it into the heart wall, and removing the helical penetrating element from the heart wall until a region of the heart wall has been wounded with helical wounds from the helical penetrating element.
Claim 13
Dependent Claim
117 words
The method of claim 4 further comprising: providing a fluid delivery lumen in the helical penetrating structure and a fluid delivery lumen in the catheter communicating from the proximal end of the catheter to the fluid delivery lumen of the helical penetrating structure; delivering a contrast agent through the fluid delivery lumen of the catheter and the fluid delivery lumen of the helical penetrating structure into the heart wall; confirming that the helical penetrating structure has been screwed into the heart wall to a desired depth by viewing the heart under fluoroscopy; delivering therapeutic agent through the fluid delivery lumen of the catheter and the fluid delivery lumen of the helical penetrating structure into the heart wall.
Claim 14
Dependent Claim
94 words
The method of claim 10 further comprising: repeating the steps of penetrating the heart wall by manipulating the helical penetrating element to engage the heart wall and rotating the helical penetrating element to screw it into the heart wall, injecting contrast agent through the fluid delivery lumen, and removing the helical penetrating element from the heart wall; prior to each repetition of the penetrating step in a subsequent penetration site, viewing the heart under fluoroscopy and identifying prior penetration sites and sites not yet penetrated to assist in selection of the subsequent penetration site.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-04-14 | 2006-10-14 | 2007-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-04-14 | 2010-10-14 | 2011-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-04-14 | 2014-10-14 | 2015-04-15 | $7700.00 | Window Closed / Lapsed |