US6521284B1
Expired / Lapsed
US
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Process for impregnating a porous material with a cross-linkable composition
Assignee: Lifeshield Sciences LLC
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Filing: 1999-11-03
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Granted: 2003-02-18
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Expires: 2019-11-03
Abstract
Abstract A process for impregnating a porous material with a cross-linkable composition is disclosed. The degree of impregnation and placement of the cross-linkable composition within the pores of the porous material can be controlled very precisely through the use of a pressure differential. The pressure differential is effected through a nonreactive gas, a vacuum, or a combination thereof. Medical devices produced using such a method are also disclosed.
Inventors
- 👤 Bruce Parsons
- 👤 Gary L. Loomis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:48
CPC Classifications
B; B29; B29B; B29B15/00; B29B15/08; B29B15/10; A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61L27/56; A61L29/00; A61L29/12; A61L29/126; A61L31/00; A61L31/12; A61L31/125; A61L31/129; A61L31/14; A61L31/146
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
379 words
A process for controllably impregnating a composition into a porous material, said process comprising: a) providing a porous material with a wall defined by an inner and an outer surface; and b) disposing a cross-linkable first composition adjacent to, or in contact with, one of said inner or said outer surfaces; and c) disposing a second composition adjacent to, or in contact with, the other of said inner or said outer surfaces not in contact with, or adjacent to, said first cross-linkable composition; and d) effecting a first pressure differential across said wall of said porous material to cause one of said cross-linkable first composition and said second composition to impregnate said porous material by a pressure means, said pressure means being selected from the group consisting of a non-reactive gas applied to said inner surface, a vacuum applied to said outer surface, and a combination of a non-reactive gas applied to said inner surface and a vacuum applied to said outer surface when said cross-linkable composition is in contact with said inner surface, or said pressure means being selected from the group consisting of a non-reactive gas applied to said outer surface and a combination of a non-reactive gas applied to said outer surface and a vacuum applied to said inner surface when said cross-linkable composition is in contact with said outer surface; and e) effecting a second pressure differential across said wall of said porous material to cause the other of said cross-linkable first composition and said second composition to impregnate said porous material by a pressure means, said pressure means being selected from the group consisting of a non-reactive gas applied to said inner surface, a vacuum applied to said outer surface, and a combination of a non-reactive gas applied to said inner surface and a vacuum applied to said outer surface when said cross-linkable composition is in contact with said inner surface, or said pressure means being selected from the group consisting of a non-reactive gas applied to said outer surface and a combination of a non-reactive gas applied to said outer surface and a vacuum applied to said inner surface when said cross-linkable composition is in contact with said outer surface; and f) effecting crosslinking of said cross-linkable first composition within said porous material.
Claim 2
Dependent Claim
379 words
A process for controllably impregnating a composition into a porous material, said process comprising: a) providing a porous material with a wall defined by an inner and an outer surface; and b) disposing a cross-linkable first composition adjacent to, or in contact with, one of said inner or said outer surfaces; and c) disposing a second composition adjacent to, or in contact with, the other of said inner or said outer surfaces not in contact with, or adjacent to, said first cross-linkable composition; and d) effecting a first pressure differential across said wall of said porous material to cause one of said cross-linkable first composition and said second composition to impregnate said porous material by a pressure means, said pressure means being selected from the group consisting of a non-reactive gas applied to said inner surface, a vacuum applied to said outer surface, and a combination of a non-reactive gas applied to said inner surface and a vacuum applied to said outer surface when said cross-linkable composition is in contact with said inner surface, or said pressure means being selected from the group consisting of a non-reactive gas applied to said outer surface and a combination of a non-reactive gas applied to said outer surface and a vacuum applied to said inner surface when said cross-linkable composition is in contact with said outer surface; and e) effecting a second pressure differential across said wall of said porous material to cause the other of said cross-linkable first composition and said second composition to impregnate said porous material by a pressure means, said pressure means being selected from the group consisting of a non-reactive gas applied to said inner surface, a vacuum applied to said outer surface, and a combination of a non-reactive gas applied to said inner surface and a vacuum applied to said outer surface when said cross-linkable composition is in contact with said inner surface, or said pressure means being selected from the group consisting of a non-reactive gas applied to said outer surface and a combination of a non-reactive gas applied to said outer surface and a vacuum applied to said inner surface when said cross-linkable composition is in contact with said outer surface; and f) effecting crosslinking of said cross-linkable first composition within said porous material.
Claim 3
Dependent Claim
64 words
The process of claim 1 , further including spacing said porous material concentrically about a mandrel, said mandrel comprising one or more openings for receiving said nonreactive gas, said vacuum, or said combination thereof, wherein said porous material and said mandrel define a cavity into which said cross-linkable first composition may be placed, and wherein said controlled impregnation is conducted in a pressure chamber.
Claim 4
Dependent Claim
21 words
The process of claim 1 , wherein said first and said second pressure differentials are from 0.1 psi to 10.0 psi.
Claim 5
Dependent Claim
20 words
The process of claim 1 , wherein said cross-linkable first composition and said second composition are the same or different.
Claim 6
Dependent Claim
14 words
The process of claim 1 , wherein said nonreactive gas is an inert gas.
Claim 7
Dependent Claim
24 words
The process of claim 1 , wherein said porous material is selected from the group consisting of polymeric materials, non-polymeric materials, and combinations thereof.
Claim 8
Dependent Claim
35 words
The process of claim 1 , wherein said porous material is a medical device selected from the group consisting of conduits, vascular grafts, endovascular grafts, stents, graft-stents, catheters, guidewires, trocars, introducer sheaths, and surgical patches.
Claim 9
Dependent Claim
42 words
The process of claim 1 , wherein said cross-linkable composition further comprises on or more bio-therapeutic agents selected from the group consisting of thrombo-resistant agents, antibiotic agents, anti-tumor agents, cell cycle regulating agents, their homologs, derivatives, fragments, pharmaceutical salts, and combinations thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-02-17 | 2006-08-19 | 2007-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-02-17 | 2010-08-19 | 2011-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-02-17 | 2014-08-19 | 2015-02-18 | $7700.00 | Window Closed / Lapsed |