US6488952B1 — Semisolid therapeutic delivery system and combina…

Claim 1

Independent Claim 120 words

A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents comprising: a biodegradable, biocompatible semisolid delivery system, said semisolid delivery system designed for injection, deposition, or implantation within or upon a body so as to provide local therapeutic effects, facilitate local or systemic release of therapeutic agents(s) in or on said body; a biodegradable, biocompatible combination semisolid, multiparticulate delivery system for injection, deposition, or implantation within or upon said body to provide local therapeutic effects, facilitate local or systemic release of therapeutic agent(s) in or on said body, wherein said biodegradable, biocompatible combination semisolid, multiparticulate delivery system is defined as a biocompatible, biodegradable material having biodegradable, biocompatible multiparticulate(s) dispersed within a biocompatible, biodegradable viscous semisolid.

Claim 2

Dependent Claim 120 words

A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents comprising: a biodegradable, biocompatible semisolid delivery system, said semisolid delivery system designed for injection, deposition, or implantation within or upon a body so as to provide local therapeutic effects, facilitate local or systemic release of therapeutic agents(s) in or on said body; a biodegradable, biocompatible combination semisolid, multiparticulate delivery system for injection, deposition, or implantation within or upon said body to provide local therapeutic effects, facilitate local or systemic release of therapeutic agent(s) in or on said body, wherein said biodegradable, biocompatible combination semisolid, multiparticulate delivery system is defined as a biocompatible, biodegradable material having biodegradable, biocompatible multiparticulate(s) dispersed within a biocompatible, biodegradable viscous semisolid.

Claim 3

Dependent Claim 62 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said body is defined as all internal and external tissues including but not limited to spaces formed via injections, surgical incisions, tumor or tissue removal, abscess formation, tissue injuries and other comparable assessment, treatment, or physiologic response to disease, injury or pathology.

Claim 4

Dependent Claim 81 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system is selected from the group consisting of biocompatible, biodegradable, semisolids having a lipophilic nature, wherein said semisolids are comprised of a hydrogel, and wherein said hydrogel is a substance formed of a solid structure or a semisolid structure exhibiting a pseudoplastic or a plastic behavior containing a necessary aqueous component for producing a gelatinous or jelly-like mass.

Claim 5

Dependent Claim 43 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 3 , wherein said hydrogel incorporates and retains significant amounts of H2O so as to eventually reach an equilibrium content in presence of said aqueous component.

Claim 6

Dependent Claim 41 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 4 , wherein said aqueous component is a buffer of electrolyte solution selected from the group consisting of phosphate buffers, H2O, and normal saline.

Claim 7

Dependent Claim 33 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 4 , wherein said hydrogel has the ability to incorporate clinically significant concentrations of lipophilic materials.

Claim 8

Dependent Claim 25 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 6 , wherein said hydrogel is glyceryl monooleate.

Claim 9

Dependent Claim 37 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 7 , wherein said GMO hydrogel is utilized to solubilize and stabilize compounds at concentrations necessary to provide therapeutic benefits.

Claim 10

Dependent Claim 85 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 3 , wherein said hydrogel, under specific levels of hydration, develops a three-dimensional structure composed of internal aqueous channels which serve to incorporate and deliver hydrophilic compounds when present and lipophilic structural walls which serve to incorporate and deliver lipophilic compounds when present, wherein said hydrogel being produced by heating said semisolid precursor above a melting point of said semisolid precursor and adding a warm said aqueous component.

Claim 11

Dependent Claim 100 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 9 , wherein said hydrogel exhibits differing gel system phases of differing viscosities based aqueous content at room temperature, wherein said room temperature being defined as between 20° C. to 25° C., and wherein said differing gel system phases comprise a lamellar phase and a cubic phase, wherein said lamellar phase and said cubic phase being the pertinent gel phases at room temperature and physiologic temperature and pH, wherein said physiologic temperature is approximately 37° C. and said pH is approximately pH 7.4.

Claim 12

Dependent Claim 57 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 10 , wherein said lamellar phase consists of approximately 5% to 15% H2O content and approximately between 95% and 85% said glyceryl monooleate content respectively in the absence of drugs, medicaments or excipients that may alter the specific phase state.

Claim 13

Dependent Claim 36 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 11 , wherein said lamellar phase is defined as a moderately viscous fluid being easily manipulated, poured and injected.

Claim 14

Dependent Claim 73 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 10 , wherein said cubic phase consists of approximately 15% to 45% H2O content and approximately between 85% and 55% said glyceryl monooleate respectively, and wherein said cubic phase has an equilibrium water content at approximately 35% to 40% by weight in the absence of drugs, medicaments or excipients that may alter the specific phase state.

Claim 15

Dependent Claim 43 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 13 , wherein said cubic phase is defined as being highly viscous, and wherein said cubic phase has a viscosity measure which exceeds 1.2 million centipoise.

Claim 16

Dependent Claim 44 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 3 , wherein said hydrogel is incorporated with a therapeutic agent so as to provide a system for immediate, sustained, or continuous delivery of said therapeutic agent.

Claim 17

Dependent Claim 27 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 15 , wherein said therapeutic agent is a lipophilic compound.

Claim 18

Dependent Claim 25 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 16 , wherein said lipophilic compound is 1,3-bis[2-chloroethyl]-1-nitrosourea.

Claim 19

Independent Claim 71 words

A method of incorporating a lipophilic therapeutic agent(s) into a semisolid, comprising the steps of: (1) combining said lipophilic therapeutic agent with said semisolid, thus producing a therapeutic agent/semisolid product; and (2) melting said product whereby said semisolid solubilizes said lipophilic therapeutic agent so as to form a resulting semisolid having a viscosity which is slightly decreased with respect to said semisolid alone, thus facilitating easier manipulation of said resulting semisolid.

Claim 20

Independent Claim 71 words

A method of incorporating a lipophilic therapeutic agent(s) into a semisolid, comprising the steps of: (1) combining said lipophilic therapeutic agent with said semisolid, thus producing a therapeutic agent/semisolid product; and (2) melting said product whereby said semisolid solubilizes said lipophilic therapeutic agent so as to form a resulting semisolid having a viscosity which is slightly decreased with respect to said semisolid alone, thus facilitating easier manipulation of said resulting semisolid.

Claim 21

Dependent Claim 21 words

The method of claim 18 , wherein said lipophilic therapeutic agent is said 1,3-bis[2-chloroethyl]-1-nitrosourea, and said semisolid is said glyceryl monooleate.

Claim 22

Independent Claim 56 words

A method of incorporating a hydrophilic therapeutic agent(s) into a semisolid, comprising the steps of: (1) melting said semisolid; (2) combining said hydrophilic therapeutic agent with a warm aqueous component; (3) heating hydrophilic therapeutic agent/aqueous component combination; and (4) combining said hydrophilic therapeutic agent/aqueous component combination with melted semisolid so as to form a malleable semisolid.

Claim 23

Independent Claim 56 words

A method of incorporating a hydrophilic therapeutic agent(s) into a semisolid, comprising the steps of: (1) melting said semisolid; (2) combining said hydrophilic therapeutic agent with a warm aqueous component; (3) heating hydrophilic therapeutic agent/aqueous component combination; and (4) combining said hydrophilic therapeutic agent/aqueous component combination with melted semisolid so as to form a malleable semisolid.

Claim 24

Dependent Claim 22 words

The method of claim 20 , wherein said aqueous component is buffered to physiological conditions, and said semisolid is said glyceryl monooleate.

Claim 25

Dependent Claim 73 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 3 , wherein said lipophilic nature of said semisolids can be altered by utilizing alternative semisolids, modified formulations, and alternative methods of production so as to allow various therapeutic agents in varying concentrations to diffuse from said semisolids at differing rates or be released from said semisolids over time via internal aqueous channels of said semisolids.

Claim 26

Dependent Claim 73 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 22 , wherein said internal aqueous channels of said semisolids are altered by said modified formulations and said methods of production so as to allow said various therapeutic agents in varying concentrations to diffuse from said semisolids at differing rates or be released from said semisolids over time via said internal aqueous channels of said semisolids.

Claim 27

Independent Claim 59 words

A method of producing an alternative semisolid comprising the steps of: (1) melting said glyceryl monooleate; (2) combining a hydrophilic surfactant with H2O; (3) heating and stirring hydrophilic surfactant/H2O combination so as to produce a spreadable paste; and (4) combining said spreadable paste with melted glyceryl monooleate so as to form an alternative cubic phase gel possessing high viscosity.

Claim 28

Independent Claim 59 words

A method of producing an alternative semisolid comprising the steps of: (1) melting said glyceryl monooleate; (2) combining a hydrophilic surfactant with H2O; (3) heating and stirring hydrophilic surfactant/H2O combination so as to produce a spreadable paste; and (4) combining said spreadable paste with melted glyceryl monooleate so as to form an alternative cubic phase gel possessing high viscosity.

Claim 29

Dependent Claim 37 words

The method of claim 24 , wherein said hydrophilic surfactant is glyceryl monostearate, and wherein said glyceryl monostearate is a surfactant agent miscible in H2O up to approximately 20%, thereby producing an 80% H2O/20% glyceryl monostearate combination.

Claim 30

Dependent Claim 46 words

The method of claim 24 , wherein said hydrophilic surfactant is polyethylene glycol, and wherein said polyethylene glycol is a surfactant agent miscible in H 2 O from 0.5% to 40% based on molecular weight, thereby producing a 99.5% to 60% H 2 O/polyethylene glycol combination.

Claim 31

Dependent Claim 57 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 5 , wherein said aqueous buffer having a surface tension or polarity being alterable when used in conjunction with hydrophilic substances which thus serves to alter a consistency of said semisolids or to alter drug release rates from said semisolids.

Claim 32

Independent Claim 88 words

A method of altering an aqueous buffer comprising the steps of: (1) placing approximately 6.25% to 12.50% concentration of hydrolyzed gelatin by weight in approximately 93.75% to 87.50% concentration of said aqueous buffer, respectively, thus producing a hydrolyzed gelatin/aqueous buffer combination; (2) heating and stirring said combination which produces a thick gelatinous substance; and (3) combining said thick gelatinous substance with glyceryl monooleate so as to form a product which swells and forms a highly viscous, translucent gel being less malleable with regard to neat glyceryl monooleate alone.

Claim 33

Independent Claim 88 words

A method of altering an aqueous buffer comprising the steps of: (1) placing approximately 6.25% to 12.50% concentration of hydrolyzed gelatin by weight in approximately 93.75% to 87.50% concentration of said aqueous buffer, respectively, thus producing a hydrolyzed gelatin/aqueous buffer combination; (2) heating and stirring said combination which produces a thick gelatinous substance; and (3) combining said thick gelatinous substance with glyceryl monooleate so as to form a product which swells and forms a highly viscous, translucent gel being less malleable with regard to neat glyceryl monooleate alone.

Claim 34

Dependent Claim 44 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 15 , wherein said therapeutic agent(s) release(s) from said hydrogel in a biphasic process, wherein said biphasic process consists of a first phase and a second phase.

Claim 35

Dependent Claim 73 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 29 , wherein said first phase is defined as where a lipophilic therapeutic agent contained within the lipophilic membrane of said hydrogel diffuses from said lipophilic membrane into said aqueous channel of said hydrogel, and wherein said second phase is defined as diffusion of said lipophilic therapeutic agent from said aqueous channel into an external environment.

Claim 36

Dependent Claim 33 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 30 , wherein said lipophilic therapeutic agent is 1,3-bis[2-chloroethyl]-1-nitrosourea, and wherein said hydrogel is glyceryl monooleate.

Claim 37

Dependent Claim 80 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 31 , wherein said 1,3-bis[2-chloroethyl]-1-nitrosourea is oriented within a lipid bi-layer structure of said glyceryl monooleate, and upon incorporation of greater than approximately 7.5% of said 1,3-bis[2-chloroethyl]-1-nitrosourea by weight into said glyceryl monooleate causes a loss of integrity of said three-dimensional structure of said glyceryl monooleate, whereby said semisolid delivery system no longer maintains said cubic phase and reverts to said lamellar phase.

Claim 38

Dependent Claim 92 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 3 , wherein said semisolid delivery system is malleable and is easily delivered and manipulated in an implant site where said semisolid delivery system adheres to and conforms to contours of resection walls of resection pockets or other voids in said body as well as fill all existing voids, thereby ensuring therapeutic distribution and uniform therapeutic delivery throughout said resection walls of said resection pockets, and thus further providing significantly increased flexibility with therapeutic dosages.

Claim 39

Dependent Claim 50 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said biocompatible multiparticulate is comprised of polymeric or non-polymeric systems utilized to produce solid structures with targeted release rates and reduced overall toxicity as compared to frequent periodic, systemic dosing.

Claim 40

Dependent Claim 37 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said solid structures are selected from the group consisting of nonpareils, pellets, crystals, agglomerates, microspheres, and nanoparticles.

Claim 41

Dependent Claim 56 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said biocompatible multiparticulate is poly(lactic-co-glycolide), and wherein said poly(lactic-co-glycolide) is a biodegradable polymer material used for controlled and extended therapeutic agent delivery within said body, and wherein said poly(lactic-co-glycolide) having a composition remaining biocompatible upon biodegradation.

Claim 42

Dependent Claim 53 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 36 , wherein said poly(lactic-co-glycolide) consists of differing molar ratios of monomeric subunits for facilitating greater flexibility in engineering precise release profiles for accommodating targeted said therapeutic agent delivery through alterations in rate of polymer degradation.

Claim 43

Dependent Claim 47 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said biocompatible multiparticulate is poly d,l(lactic-co-caprolactone), and wherein said poly d,l(lactic-co-caprolactone) is a biodegradable polymer material used for controlled and extended therapeutic agent delivery within said body.

Claim 44

Dependent Claim 70 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said biocompatible polymeric multiparticulate is encapsulated or coated with a desired, suitable polymer of a same composition with a same or different therapeutic substances so as to allow for production of an encapsulated multiparticulate system having a wide range of therapeutic release profiles for single or multiple therapeutic agents simultaneously.

Claim 45

Dependent Claim 70 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said biocompatible, polymeric, multiparticulate is encapsulated or coated with a desired, suitable polymer of a different composition with a same or different therapeutic substances, so as to allow for production of an encapsulated multiparticulate system having a wide range of therapeutic release profiles for single or multiple therapeutic agents simultaneously.

Claim 46

Dependent Claim 75 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said biocompatible multiparticulate is encapsulated or coated with a single or multiple encapsulating processes containing either no therapeutic agent, the same therapeutic agent, or a plurality of therapeutic agents, so as to allow for production of an encapsulated multiparticulate system having a wide range of therapeutic release profiles for single or multiple therapeutic agents simultaneously.

Claim 47

Dependent Claim 63 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 36 , wherein said poly(lactic-co-glycolide) is designed and configured into said microspheres via an emulsification/solvent-evaporation method, wherein said therapeutic agent or a drug is entrapped in said microspheres, whereby said therapeutic agent or said drug is subsequently released from said microspheres via a drug release mechanism.

Claim 48

Dependent Claim 67 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 42 , wherein said poly(lactic-co-glycolide) contains ester bonds which are labile to hydrolysis, whereupon subsequent penetration by H2O of said poly(lactic-co-glycolide) actuates hydrolyzation of said ester bonds, and monomers being water soluble, are removed from said poly(lactic-co-glycolide), thus facilitating physical release of said therapeutic agent or said drug over time.

Claim 49

Dependent Claim 47 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 34 , wherein said polymeric or non-polymeric systems are selected from the group consisting of polyanhydrides, poly(phosphates), polydioxanone, cellulosics, acrylics, sterols, sucrose, fatty acid esters, fatty acids, and cholesteryl esters.

Claim 50

Independent Claim 152 words

A method of producing poly(lactic-co-glycolide) polymer microsphere for incorporation into semisolid comprising the steps of: (1) dissolving suitably desired therapeutic agent and said poly(lactic-co-glycolide) polymer in a suitable solvent; (2) transferring said suitably desired therapeutic agent, said poly(lactic-co-glycolide) polymer, and a suitable solvent to an aqueous buffer having an emulsifying agent in a ratio of approximately 1.5:1 to 2.0:1 (aqueous buffer: polymer solution), which thus forms small droplets or microspheres; (3) agitating said microspheres for 15-30 minutes at room temperature; (4) increasing the temperature to approximately 40° C. to 45° C. and continuing agitation for approximately 90-115 minutes; (5) removing said microspheres from heat and agitation, collecting said microspheres by filtration, and washing said microspheres with distilled water; (6) collecting said microspheres in a suitable container, flash freezing said microspheres to −70° C. and drying in a lyophilizer at −40° C. for 48 hours; and (7) incorporating said microspheres into said semisolid.

Claim 51

Independent Claim 152 words

A method of producing poly(lactic-co-glycolide) polymer microsphere for incorporation into semisolid comprising the steps of: (1) dissolving suitably desired therapeutic agent and said poly(lactic-co-glycolide) polymer in a suitable solvent; (2) transferring said suitably desired therapeutic agent, said poly(lactic-co-glycolide) polymer, and a suitable solvent to an aqueous buffer having an emulsifying agent in a ratio of approximately 1.5:1 to 2.0:1 (aqueous buffer: polymer solution), which thus forms small droplets or microspheres; (3) agitating said microspheres for 15-30 minutes at room temperature; (4) increasing the temperature to approximately 40° C. to 45° C. and continuing agitation for approximately 90-115 minutes; (5) removing said microspheres from heat and agitation, collecting said microspheres by filtration, and washing said microspheres with distilled water; (6) collecting said microspheres in a suitable container, flash freezing said microspheres to −70° C. and drying in a lyophilizer at −40° C. for 48 hours; and (7) incorporating said microspheres into said semisolid.

Claim 52

Dependent Claim 28 words

The method of claim 45 , wherein said suitably desired therapeutic agent is said 1,3-bis[2-chloroethyl]-1-nitrosourea, said suitable solvent is methylene chloride, and said emulsifying agent is polyvinyl alcohol.

Claim 53

Dependent Claim 37 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 42 , wherein said emulsification/solvent-evaporation method produces a solution whereby said therapeutic agent is homogeneously dispersed throughout said poly(lactic-co-glycolide) polymer.

Claim 54

Dependent Claim 43 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system serves to fill a void volume left by tissue resection, thus reducing a possibility of tissue and fluid shifts.

Claim 55

Dependent Claim 66 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system and said combination semisolid multiparticulate delivery system can be injected into an abscess pocket, stemming from infectious diseases of central nervous system such as fungal abscesses and bacterial abscesses, following drainage so as to facilitate a very, high, localized concentration of antibiotics.

Claim 56

Dependent Claim 39 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system resists microbial growth within or upon said semisolid delivery system upon exposure to microbial challenges.

Claim 57

Dependent Claim 43 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system is formulated with a low aqueous or semi-polar solvent content so as to provide a formulation which facilitates hemostasis.

Claim 58

Dependent Claim 64 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 51 , wherein said formulation being exposed to or in direct contact with a high aqueous content environment, such as blood or lymph, creates a zone of contact between said formulation and said high aqueous content environment, whereby said zone hydrates and forms a solid cubic phase.

Claim 59

Dependent Claim 60 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system and said combination semisolid multiparticulate therapeutic delivery system are designed and configured to deliver said therapeutic agents to pathological conditions of skin or superficial structures of said body such as decubitus ulcers and surgical sound infections.

Claim 60

Dependent Claim 69 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid delivery system and said combination semisolid multiparticulate therapeutic delivery system may be incorporated with a neuroprotective agent for implantation or injection in said body at a time of post-operative evacuation of a hematoma resulting from stroke so as to alleviate neural damage associated with a residual clot.

Claim 61

Dependent Claim 68 words

The semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic agents of claim 1 , wherein said semisolid and said combination semisolid multiparticulate delivery system are incorporated with members selected from the group consisting of biologically-active agents, drugs, medicaments, inactives, other therapeutic agents, and chemically modified equivalents and combinations thereof for providing a local or systemic biological, physiological, or therapeutic effect in said body.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2005-12-02	2006-06-03	2006-12-03	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2009-12-02	2010-06-03	2010-12-03	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2013-12-02	2014-06-03	2014-12-03	$7700.00	Window Closed / Lapsed

Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag