US6028164A
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Bioresorbable compositions for implantable prostheses
Assignee: Lifeshield Sciences LLC
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Filing: 1999-02-01
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Granted: 2000-02-22
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Expires: 2019-02-01
Abstract
Abstract Crosslinked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable functional groups per polymer chain. These compositions are able to form hydrogels in aqueous environments when crosslinked. These hydrogels are good sealants for implantable prostheses when in contact with an aqueous environment. In addition, such hydrogels can be used as delivery vehicles for therapeutic agents.
Inventors
- 👤 Gary L. Loomis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 07:34
CPC Classifications
C; C08; C08G; C08G64/00; C08G64/18; C08G64/183; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/2031; A61K9/204; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/52; A61L27/54; A61L27/58; A61P; A61P7/00; A61P7/02; C08G63/00; C08G63/66; C08G63/664; C08G63/668; C08G63/676; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/408; A61L2300/41; A61L2300/416; A61L2300/42; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
33 words
A covalently crosslinkable composition comprising a polymerizable compound corresponding to the following general formula: ##STR2## wherein x is from about 10 to about 50 and y is from about 50 to about 300.
Claim 2
Dependent Claim
33 words
A covalently crosslinkable composition comprising a polymerizable compound corresponding to the following general formula: ##STR2## wherein x is from about 10 to about 50 and y is from about 50 to about 300.
Claim 3
Dependent Claim
29 words
The composition of claim 1, wherein said polymerizable compound has (1) a bioresorbable region; (2) a hydrophilic region; and (3) a plurality of crosslinkable functional groups per polymer chain.
Claim 4
Dependent Claim
11 words
The composition of claim 2, wherein said bioresorbable region is hydrophobic.
Claim 5
Dependent Claim
18 words
The composition of claim 2, wherein said bioresorbable region has hydrophilic character without rendering the polymerizable compound water-soluble.
Claim 6
Dependent Claim
14 words
The composition of claim 2, wherein said bioresorbable region is hydrolytically and/or enzymatically cleavable.
Claim 7
Dependent Claim
15 words
The composition of claim 2, wherein said hydrophilic region forms an excretable and/or metabolizable fragment.
Claim 8
Dependent Claim
28 words
The composition of claim 2, wherein the relative properties and proportions of said bioresorbable region and said hydrophilic region are selected to render said composition insoluble in water.
Claim 9
Dependent Claim
18 words
The composition of claim 1, wherein said composition is crosslinkable by high energy, thermal radiation, or visible light.
Claim 10
Dependent Claim
11 words
The composition of claim 1 further comprising a free radical initiator.
Claim 11
Dependent Claim
17 words
The composition of claim 9, wherein said free radical initiator is a peroxide or an azo compound.
Claim 12
Dependent Claim
13 words
The composition of claim 10, wherein said azo compound is 2,2'-Azobis (N,N'dimethyleneisobutyramidine) dihydrochloride.
Claim 13
Dependent Claim
15 words
The composition of claim 1, wherein said polymerizable compound is crosslinkable in a non-humid environment.
Claim 14
Dependent Claim
15 words
The composition of claim 1, wherein said polymerizable compound is crosslinkable in a humid environment.
Claim 15
Dependent Claim
25 words
The composition of claim 13, wherein said humid environment contains from about 20% to about 100% water, preferably from about 60% to about 100% water.
Claim 16
Dependent Claim
14 words
The composition of claim 1, wherein said polymerizable compound forms a hydrogel when crosslinked.
Claim 17
Dependent Claim
19 words
The composition of claim 15, wherein said hydrogel further comprises a drug or bioactive agent incorporated within its matrix.
Claim 18
Dependent Claim
43 words
The composition of claim 16, herein said drug or bio-active agent is selected from the group consisting of thrombo-resistant agents, antibiotic agents, anti-tumor agents, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-inflammatory agents, cell cycle regulating agents, and chemically modified equivalents and combinations thereof.
Claim 19
Dependent Claim
39 words
The composition of claim 17, wherein said thrombo-resistant agent is selected from the group consisting of heparin, heparin sulfate, hirudin, hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, lytic agents, urokinase, streptokinase, and chemically modified equivalents and combinations thereof.
Claim 20
Dependent Claim
35 words
The composition of claim 17, wherein said antibiotic agent is selected from the group consisting of penicillins, cephalosporins, vancomycins, aminoglycosides, quinolones, polymyxins, erthromycins, tetracyclines, chloramphenicols, clindamycins, lincomycins, sulfonamides, and chemically modified equivalents and combinations thereof.
Claim 21
Dependent Claim
47 words
The composition of claim 17, wherein said anti-tumor agent is selected from the group consisting of paclitaxel, mechlorethamine, chlorambucil, cyclophosphamide, melphalan, ifosfamide, methotrexate, 6-mercaptopurine, 5-fluorouracil, cytarabine, vinblastine, vincristine, etoposide, doxorubicin, daunomycin, bleomycin, mitomycin, carmustijne, lomustine, cisplatin, interferon, asparaginase, tamoxifen, flutamide, and chemically modified equivalents and combinations thereof.
Claim 22
Dependent Claim
34 words
The compositions of claim 17, wherein said anti-viral agent is selected from the group consisting of amantadines, rimantadines, ribavirins, idoxuridines, vidarabines, trifluridines, acyclovirs, ganciclovirs, zidovudiens, foscarnets, interferons, and chemically modified equivalents and combinations thereof.
Claim 23
Dependent Claim
45 words
A covalently crosslinkable composition comprising a water-insoluble copolymer having (i) a bioresorbable region; (ii) a hydrophilic region; and (iii) a plurality of crosslinkable functional groups per polymer chain, wherein the copolymer is selected from the group consisting of di-block copolymers, tri-block copolymers, and star copolymers.
Claim 24
Dependent Claim
45 words
A covalently crosslinkable composition comprising a water-insoluble copolymer having (i) a bioresorbable region; (ii) a hydrophilic region; and (iii) a plurality of crosslinkable functional groups per polymer chain, wherein the copolymer is selected from the group consisting of di-block copolymers, tri-block copolymers, and star copolymers.
Claim 25
Dependent Claim
34 words
The covalently crosslinkable composition of claim 22, wherein said tri-block copolymer has the general formula: xABAx wherein A is the bioresorbable region, B is the hydrophilic region, and x is the crosslinkable functional group.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2003-02-21 | 2003-08-23 | 2004-02-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-02-21 | 2007-08-23 | 2008-02-22 | $3760.00 | Window Closed / Lapsed |
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