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US6482898B1
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Halogenated wang resins for combinatorial chemical synthesis
Assignee: Korea Research Institute of Chemical Technology
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Filing: 1999-08-19
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Granted: 2002-11-19
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Expires: 2019-08-19
Abstract
Abstract The present invention relates to novel halogenated Wang resins for combinational chemical synthesis, more specifically to halogenated Wang resins expressed by formula (1) useful for the effective tracing of combinational chemical synthetic process on solid supports using X-ray photoelectron spectroscopy (XPS) element analysis method; in formula (1), P represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Inventors
- 👤 Sung Eun Yoo
- 👤 Young Dae Gong
- 👤 Jin Soo Seo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:01
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/18; C07; C07C; C07C43/00; C07C43/02; C07C43/20; C07C43/23; C07B; C07B2200/00; C07B2200/11
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
51 words
Halogenated Wang resin expressed by the following formula 1, which is useful for combinatorial chemical synthesis, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 2
Dependent Claim
51 words
Halogenated Wang resin expressed by the following formula 1, which is useful for combinatorial chemical synthesis, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 3
Dependent Claim
94 words
Preparing method of halogenated Wang resin expressed by formula 1, which comprises: (a) halogenating 4-hydroxybenzyl alcohol expressed by the following Formula 2 to halogenated 4-hydroxybenzyl alcohol expressed by the following formula 3; and (b) reacting the compound expressed by formula 3 with Merrifield resin expressed by the following formula 4 to prepare halogenated Wang resin expressed by formula 1, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 4
Dependent Claim
94 words
Preparing method of halogenated Wang resin expressed by formula 1, which comprises: (a) halogenating 4-hydroxybenzyl alcohol expressed by the following Formula 2 to halogenated 4-hydroxybenzyl alcohol expressed by the following formula 3; and (b) reacting the compound expressed by formula 3 with Merrifield resin expressed by the following formula 4 to prepare halogenated Wang resin expressed by formula 1, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 5
Dependent Claim
31 words
Preparing method of halogenated Wang resin according to claim 2 , wherein the said halogenation is performed using bromine (Br 2 ) or thionyl chloride (SOCl 2 ) as halogenating agent.
Claim 6
Dependent Claim
27 words
Preparing method of halogenated Wang resin according to claim 2 , wherein the introduction to Merrifield resin is performed in the presence of sodium alkoxide or base.
Claim 7
Dependent Claim
60 words
Quantitative analysis using XPS (X-ray photoelectron spectroscopy) of the product of combinatorial chemical synthesis using halogenated Wang resin expressed by formula 1 as solid support, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 8
Dependent Claim
60 words
Quantitative analysis using XPS (X-ray photoelectron spectroscopy) of the product of combinatorial chemical synthesis using halogenated Wang resin expressed by formula 1 as solid support, wherein {circle around (P)} represents polystyrene-divinylbenzene; X and Y represent hydrogen atom or halogen atom, which may be identical or different, their total number being 1-4; and at least one of them is halogen atom.
Claim 9
Dependent Claim
27 words
Quantitative analysis of the product of combinatorial chemical synthesis according to claim 5 , wherein the combinatorial chemical synthesis is organic synthesis, peptide synthesis or carbohydrate synthesis.
References Cited (Backward Citations)
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