US6470220B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnosis and treatment of cancers using in vivo magnetic domains
Assignee: Los Alamos National Laboratory
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Filing: 2000-03-29
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Granted: 2002-10-22
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Expires: 2020-03-29
Abstract
Abstract A method of detecting and treating tumors within a subject is disclosed together with a process for the non-invasive measurement of tissue temperature within a subject.
Inventors
- 👤 Robert H. Kraus, Jr.
- 👤 Don M. Coates
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:59
CPC Classifications
A; A61; A61N; A61N2/00; A61K; A61K41/00; A61K41/0052; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/773; Y10S977/775; Y10S977/788; Y10S977/802; Y10S977/806; Y10S977/808; Y10S977/902; Y10S977/904; Y10S977/92; Y10S977/932; Y10S977/953; Y10S977/957; Y10S977/958; Y10S977/959; Y10S977/96
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
138 words
A method of detecting and treating tumors within a subject comprising: administering a dosage of magnetic material containing substance to a subject, said magnetic material containing substance adapted for preferential attachment to tumor cells; detecting location within said subject of said magnetic material containing substance attached to tumor cells by use of a sensor array including superconducting quantum interference devices; and, manipulating by a low frequency field said magnetic material within said subject such that said magnetic material containing substance undergoes heating whereby tumor cells having said attached magnetic material are heated sufficiently to cause selective necrosis of at least a portion of said tumor cells, wherein said manipulating magnetic material within said subject includes applying a rotational field to selected portions of said subject whereby said magnetic material containing substance undergoes a rotation to yield viscous heating.
Claim 2
Independent Claim
138 words
A method of detecting and treating tumors within a subject comprising: administering a dosage of magnetic material containing substance to a subject, said magnetic material containing substance adapted for preferential attachment to tumor cells; detecting location within said subject of said magnetic material containing substance attached to tumor cells by use of a sensor array including superconducting quantum interference devices; and, manipulating by a low frequency field said magnetic material within said subject such that said magnetic material containing substance undergoes heating whereby tumor cells having said attached magnetic material are heated sufficiently to cause selective necrosis of at least a portion of said tumor cells, wherein said manipulating magnetic material within said subject includes applying a rotational field to selected portions of said subject whereby said magnetic material containing substance undergoes a rotation to yield viscous heating.
Claim 3
Dependent Claim
58 words
A process for the non-invasive measurement of tissue temperature within a subject comprising: administering a dosage of magnetic material containing substance to a subject, said magnetic material containing substance adapted for preferential attachment to selected tissue; measuring Barkhausen noise associated with magnetic domains delivered to such selected tissue; and, correlating a tissue temperature with said measured Barkhausen noise.
Claim 4
Dependent Claim
58 words
A process for the non-invasive measurement of tissue temperature within a subject comprising: administering a dosage of magnetic material containing substance to a subject, said magnetic material containing substance adapted for preferential attachment to selected tissue; measuring Barkhausen noise associated with magnetic domains delivered to such selected tissue; and, correlating a tissue temperature with said measured Barkhausen noise.
Claim 5
Dependent Claim
28 words
The process of claim 2 wherein said non-invasive measurement of tissue temperature is employed in a feedback loop for the detection and treatment of tumors within a subject.
References Cited (Backward Citations)
US4303636A
Cited
US4106488A
Cited
US4136683A
Cited
US4569836A
Cited
US4731239A
Cited
US5043101A
Cited
US4590922A
Cited
US4735796A
Cited
US5622686A
Cited
US5197940A
Cited
US5427767A
Cited
US5735279A
Cited
US5604112A
Cited
US6048515A
Cited
US6167313A
Cited
US6149576A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-10-21 | 2006-04-22 | 2006-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-10-21 | 2010-04-22 | 2010-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-10-21 | 2014-04-22 | 2014-10-22 | $7700.00 | Window Closed / Lapsed |