Patent US6440096B1 successfully refreshed from Google Patents.
US6440096B1
Expired / Lapsed
US
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Microdevice and method of manufacturing a microdevice
Assignee: Becton Dickinson and Co
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Filing: 2000-07-14
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Granted: 2002-08-27
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Expires: 2020-07-14
Abstract
Abstract A device for monitoring, sampling or delivering a substance though the skin of a patient includes a support and a microdevice having at least one skin penetrating member. The support has a substantially flat bottom surface with the skin penetrating member extending beyond the bottom surface. An outlet port extends through the support to the bottom surface at a location between the skin penetrating member and the outer edge of the support for drawing a vacuum to enhance penetration of the skin. The device is produced by positioning the microdevice in a recess formed in the support and applying a bonding agent to wick into a gap formed between the microdevice and the wall of the recess.
Inventors
- 👤 Alexander G. Lastovich
- 👤 John D. Evans
- 👤 Ronald J. Pettis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:44
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0015; A61B; A61B17/00; A61B17/20; A61B17/205; A61B5/00; A61B5/145; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/15; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/150053; A61B5/150061; A61B5/150099; A61B5/150977; A61B5/150984; A61B5/151; A61B5/15142; A61M2037/0023; A61M2037/003; A61M2037/0038
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
121 words
A method of forming a microdevice for delivering or withdrawing a substance through the skin of a patient, comprising the steps of: providing a support having a bottom face with a recessed area having a dimension less than a dimension of said bottom face, positioning a skin penetrating device in said recessed area of said support, said skin penetrating device having a base and at least one skin penetrating member, said base having a dimension less than said dimension of said recessed area, and applying a bonding amount of a bonding agent to at least one location between said support and said base in said recessed area, said bonding agent having a viscosity to wick between said base and said support.
Claim 2
Independent Claim
121 words
A method of forming a microdevice for delivering or withdrawing a substance through the skin of a patient, comprising the steps of: providing a support having a bottom face with a recessed area having a dimension less than a dimension of said bottom face, positioning a skin penetrating device in said recessed area of said support, said skin penetrating device having a base and at least one skin penetrating member, said base having a dimension less than said dimension of said recessed area, and applying a bonding amount of a bonding agent to at least one location between said support and said base in said recessed area, said bonding agent having a viscosity to wick between said base and said support.
Claim 3
Dependent Claim
22 words
The method of claim 1 , wherein said base is a silicon wafer and said skin penetrating member is a microneedle array.
Claim 4
Dependent Claim
16 words
The method of claim 1 , wherein said base has a thickness of about 250 microns.
Claim 5
Dependent Claim
23 words
The method of claim 1 , wherein said recessed area has a depth equal to or less than a thickness of said base.
Claim 6
Dependent Claim
53 words
The method of claim 1 , wherein said recessed area has a bottom surface parallel with said bottom face of said support and a side face extending between said bottom face of said support and said bottom surface of said recess, said method comprising positioning said skin penetrating device on said bottom surface.
Claim 7
Dependent Claim
24 words
The method of claim 5 , wherein said side face of said recessed area is substantially perpendicular to said bottom face of said support.
Claim 8
Dependent Claim
39 words
The method of claim 5 , wherein said recessed area is dimensioned to define a gap between said side face and said base of said skin penetrating member, and said method comprises applying said bonding agent to said gap.
Claim 9
Dependent Claim
38 words
The method of claim 1 , wherein said support includes at least one channel communicating with said recessed area, said method comprising applying said bonding agent to said channel whereby said bonding agent flows into said recessed area.
Claim 10
Dependent Claim
23 words
The method of claim 8 , wherein said at least one channel is an open channel on said bottom face of said support.
Claim 11
Dependent Claim
58 words
The method of claim 8 , wherein said at least one channel has a first end connected to said recessed area and a second end connected to a reservoir formed in said support, said method comprising applying said bonding agent to said reservoir whereby said bonding agent flows through said at least one channel to said recessed area.
Claim 12
Dependent Claim
17 words
The method of claim 1 , wherein said support has a cavity communicating with said recessed area.
Claim 13
Dependent Claim
20 words
The method of claim 11 , wherein said support includes an opening extending from a top face to said cavity.
Claim 14
Dependent Claim
30 words
The method of claim 10 , wherein said support has at least one port communicating with said bottom face, said at least one port being spaced from said recessed area.
Claim 15
Dependent Claim
30 words
The method of claim 1 , wherein said base of said penetrating device is a silicon wafer and said at least one skin penetrating member is an array of microneedles.
Claim 16
Dependent Claim
32 words
The method of claim 1 , wherein said skin penetrating device includes at least one passage extending through said base and being in communication with said at least one skin penetrating member.
Claim 17
Independent Claim
120 words
A method of withdrawing a substance or delivering a substance through the skin of a patient, said method comprising providing a support having a central passage, a bottom face, a one skin penetrating device on said bottom face, said central passage being in communication with said skin penetrating device, positioning said support on the skin of a patient with said bottom face of said support and said at least one skin penetrating device contacting said skin, reducing the pressure in an area between said support and said skin to draw said skin toward said skin penetrating member and to cause said skin penetrating device to penetrate said skin, and withdrawing or delivering a substance through the skin of said patient.
Claim 18
Independent Claim
120 words
A method of withdrawing a substance or delivering a substance through the skin of a patient, said method comprising providing a support having a central passage, a bottom face, a one skin penetrating device on said bottom face, said central passage being in communication with said skin penetrating device, positioning said support on the skin of a patient with said bottom face of said support and said at least one skin penetrating device contacting said skin, reducing the pressure in an area between said support and said skin to draw said skin toward said skin penetrating member and to cause said skin penetrating device to penetrate said skin, and withdrawing or delivering a substance through the skin of said patient.
Claim 19
Dependent Claim
47 words
The method of claim 16 , wherein said bottom face of said support includes a recessed area having a dimension less than a dimension of said bottom face, and wherein said skin penetrating device includes a base fitted in said recessed area and coupled to said support.
Claim 20
Dependent Claim
39 words
The method of claim 16 , wherein said support has an outer edge spaced from and surrounding said at least one skin penetrating member and an annular flange coupled to said outer edge and extending away from said support.
Claim 21
Dependent Claim
53 words
The method of claim 18 , wherein said support further includes an outlet port communicating with said bottom face of said support between said annular flange and said skin penetrating member, and said method comprises applying a vacuum source to said outlet port to reduce the pressure between said support and said skin.
Claim 22
Dependent Claim
24 words
The method of claim 16 , wherein said skin penetrating device includes an axial passage in communication with said central passage of said support.
Claim 23
Dependent Claim
38 words
The method of claim 16 , wherein said at least one skin penetrating device comprises an array of skin penetrating members, said skin penetrating members being selected from the group consisting of microtubes, microneedles, cannulas, blades and lancets.
Claim 24
Dependent Claim
34 words
The method of claim 16 , wherein said support includes a fluid coupling communicating with said central passage, said method comprising withdrawing or supplying a substance through said fluid coupling to said central passage.
Claim 25
Dependent Claim
22 words
The method of claim 19 , comprising coupling a vacuum source to said outlet port and drawing a vacuum through said coupling.
Claim 26
Independent Claim
90 words
A device for delivering or withdrawing a substance from a patient, said device comprising: a support member having a bottom face and a recessed area having a dimension less than a dimension of said bottom face, a skin penetrating device having a base and at least one skin penetrating member, said base being positioned within said recessed area of said support, and a bonding material attaching said skin penetrating device to said support member and filling a space between said recessed area and said base of said skin penetrating device.
Claim 27
Independent Claim
90 words
A device for delivering or withdrawing a substance from a patient, said device comprising: a support member having a bottom face and a recessed area having a dimension less than a dimension of said bottom face, a skin penetrating device having a base and at least one skin penetrating member, said base being positioned within said recessed area of said support, and a bonding material attaching said skin penetrating device to said support member and filling a space between said recessed area and said base of said skin penetrating device.
Claim 28
Dependent Claim
22 words
The device of claim 24 , wherein said base is a silicon wafer and said skin penetrating member is a microneedle array.
Claim 29
Dependent Claim
16 words
The device of claim 24 , wherein said base has a thickness of about 250 microns.
Claim 30
Dependent Claim
41 words
The device of claim 24 , wherein said recessed area has a bottom surface parallel with said bottom face of said support and a side face extending between said bottom face of said support and said bottom surface of said recess.
Claim 31
Dependent Claim
24 words
The device of claim 27 , wherein said side face of said recessed area is substantially perpendicular to said bottom face of said support.
Claim 32
Dependent Claim
28 words
The device of claim 24 , wherein said support includes at least one channel communicating with said recessed area for directing said bonding material into said recessed area.
Claim 33
Dependent Claim
23 words
The device of claim 29 , wherein said at least one channel is an open channel on said bottom face of said support.
Claim 34
Dependent Claim
34 words
The device of claim 24 , wherein said support has at least one port communicating with said bottom face of said support between an outer edge of said support and said skin penetrating device.
Claim 35
Dependent Claim
32 words
The device of claim 24 , wherein said skin penetrating device includes at least one passage extending through said base and being in communication with said at least one skin penetrating member.
Claim 36
Dependent Claim
31 words
The device of claim 32 , wherein said support includes a port and a central passage communicating with said skin penetrating device for delivering or withdrawing a fluid through said device.
Claim 37
Dependent Claim
37 words
The device of claim 24 , wherein said support has an outer edge spaced from and surrounding said skin penetrating device and a flange extending from said outer edge away from said bottom face of said support.
Claim 38
Dependent Claim
27 words
The device of claim 34 , wherein said flange is dimensioned to contact the skin of a patient and wherein said flange includes a friction enhancing member.
Claim 39
Dependent Claim
14 words
The device of claim 35 , wherein said friction enhancing member is a ridge.
Claim 40
Dependent Claim
15 words
The device of claim 35 , wherein said friction enhancing member is a tacky material.
Claim 41
Dependent Claim
37 words
The device of claim 34 , wherein said support further comprises a port communicating with said bottom face of said support between said flange and said skin penetrating device, and an outlet coupling communicating with said port.
Claim 42
Independent Claim
86 words
A device for delivering or withdrawing a substance from a patient, said device comprising: a support member having a bottom face, an outer edge, and a recessed area having a dimension less than a dimension of said bottom face, said support having at least one passage communicating with said bottom face between said recessed area and said outer edge, a skin penetrating device having a base and at least one skin penetrating member, said base being positioned within said recessed area and coupled to said support.
Claim 43
Independent Claim
86 words
A device for delivering or withdrawing a substance from a patient, said device comprising: a support member having a bottom face, an outer edge, and a recessed area having a dimension less than a dimension of said bottom face, said support having at least one passage communicating with said bottom face between said recessed area and said outer edge, a skin penetrating device having a base and at least one skin penetrating member, said base being positioned within said recessed area and coupled to said support.
Claim 44
Dependent Claim
31 words
The device of claim 39 , wherein said support includes a port and a central passage communicating with said skin penetrating device for delivering or withdrawing a fluid through said device.
Claim 45
Dependent Claim
20 words
The device of claim 40 , further comprising a flange on said outer edge extending away from said bottom face.
Claim 46
Dependent Claim
24 words
The device of claim 41 , wherein said flange is dimensioned to contact the skin of a patient and includes a friction enhancing member.
Claim 47
Dependent Claim
15 words
The device of claim 41 , wherein said skin penetrating member is a microneedle array.
Claim 48
Independent Claim
97 words
A method of forming a microdevice, comprising the steps of: providing a support having a bottom face with a recessed area having a dimension less than a dimension of said bottom face and at least one channel with said recessed area, positioning a microdevice in said recessed area of said support, said microdevice having a base with a dimension less than said dimension of said recessed area, and applying a bonding amount of a bonding agent to said channel, said bonding agent having a viscosity to wick along said channel and between said base and said support.
Claim 49
Independent Claim
97 words
A method of forming a microdevice, comprising the steps of: providing a support having a bottom face with a recessed area having a dimension less than a dimension of said bottom face and at least one channel with said recessed area, positioning a microdevice in said recessed area of said support, said microdevice having a base with a dimension less than said dimension of said recessed area, and applying a bonding amount of a bonding agent to said channel, said bonding agent having a viscosity to wick along said channel and between said base and said support.
Claim 50
Dependent Claim
23 words
The method of claim 44 , wherein said at least one channel is an open channel on said bottom face of said support.
Claim 51
Dependent Claim
58 words
The method of claim 45 , wherein said at least one channel has a first end connected to said recessed area and a second end connected to a reservoir formed in said support, said method comprising applying said bonding agent to said reservoir whereby said bonding agent flows through said at least one channel to said recessed area.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-08-26 | 2006-02-25 | 2006-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-08-26 | 2010-02-25 | 2010-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-08-26 | 2014-02-25 | 2014-08-27 | $7700.00 | Window Closed / Lapsed |