Patent US6322808B1 successfully refreshed from Google Patents.
US6322808B1
Expired / Lapsed
US
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Device for enhancing transdermal agent flux
Assignee: Alza Corp
•
Filing: 1998-12-09
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Granted: 2001-11-27
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Expires: 2018-12-09
Abstract
Abstract A device ( 3 ) comprising a sheet member ( 6 ) having a plurality of microprotrusions ( 4 ) for penetrating the skin and a rigid support ( 15 ) contacting and extending across the sheet member ( 6 ) for transmitting an applied force evenly across the length and width of the sheet member ( 6 ) to reproducibly and reliably penetrate the skin with the microprotrusions ( 4 ).
Inventors
- 👤 Joseph Creagan Trautman
- 👤 Patrick S.-L. Wong
- 👤 Peter E. Daddona
- 👤 Hyunok Lynn Kim
- 👤 Michael G. Zuck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:25
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0015; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/1451; A61B5/14514; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0021; A61B10/00; A61B10/0045; A61B2010/008; A61M2037/0007; A61M2037/0023; A61M2037/003; A61M2037/0038; A61M2037/0046; A61M2037/0053; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61N1/306
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
104 words
A device for use in introducing or withdrawing an agent through a body surface, comprising: a thin, flexible sheet-like member having a plurality of microprotrusions extending from a body surface proximal portion of the member; and a structural support which defines one or more voids for an agent-containing or agent receiving reservoir and which extends substantially across, and makes contact substantially across, a width, length and/or diameter of the member, the support having greater rigidity than the member and wherein the structural support substantially reduces the tendency of the member to deflect upon application of a force to the top of the structural support.
Claim 2
Independent Claim
104 words
A device for use in introducing or withdrawing an agent through a body surface, comprising: a thin, flexible sheet-like member having a plurality of microprotrusions extending from a body surface proximal portion of the member; and a structural support which defines one or more voids for an agent-containing or agent receiving reservoir and which extends substantially across, and makes contact substantially across, a width, length and/or diameter of the member, the support having greater rigidity than the member and wherein the structural support substantially reduces the tendency of the member to deflect upon application of a force to the top of the structural support.
Claim 3
Dependent Claim
25 words
The device of claim 1 , wherein the support has greater rigidity to a force applied perpendicular to the body surface than does the member.
Claim 4
Dependent Claim
30 words
The device of claim 1 , wherein the support is sufficiently rigid to deflect less than 300 μm under manually applied finger or hand pressing of the device against skin.
Claim 5
Dependent Claim
17 words
The device of claim 3 , wherein the support deflects less than 50 μm under said pressing.
Claim 6
Dependent Claim
30 words
The device of claim 1 , wherein the support is sufficiently incompressible to compress less than 250 μm under manually applied finger or hand pressing of the device against skin.
Claim 7
Dependent Claim
17 words
The device of claim 5 , wherein the support compresses less than 50 μm under said pressing.
Claim 8
Dependent Claim
54 words
The device of claim 1 , wherein the member comprises a sheet which in use is oriented approximately parallel to the body surface, the sheet having a plurality of openings therein and the plurality of microprotrusions extending from a body proximal surface of the sheet, said microprotrusions being adapted to pierce the body surface.
Claim 9
Dependent Claim
34 words
The device of claim 1 , wherein the structural support comprises a plurality of cross-members, the cross-members being spaced no more than about 4 times a distance between adjacent microprotrusions in said microprotrusion member.
Claim 10
Dependent Claim
19 words
The device of claim 7 , wherein the reservoir is in agent-transmitting communication with the openings in the sheet.
Claim 11
Dependent Claim
18 words
The device of claim 1 , wherein the support comprises a peripheral member and a plurality of cross-members.
Claim 12
Dependent Claim
13 words
The device of claim 1 , wherein the support has a honeycomb structure.
Claim 13
Dependent Claim
13 words
The device of claim 1 , wherein the support comprises a corrugated sheet.
Claim 14
Dependent Claim
17 words
The device of claim 1 , wherein the support has a curved surface which contacts the member.
Claim 15
Dependent Claim
22 words
The device of claim 13 , wherein the curved surface has a shape selected from the group consisting of convex and cylindrical.
Claim 16
Dependent Claim
22 words
The device of claim 7 , wherein the support comprises a plurality of wavy strips arranged in perpendicular alignment to the sheet.
Claim 17
Dependent Claim
17 words
The device of claim 1 , wherein the member has a thickness of less than 100 μm.
Claim 18
Dependent Claim
13 words
The device of claim 16 , wherein the member is comprised of metal.
Claim 19
Dependent Claim
61 words
The device of claim 1 , wherein the member comprises a sheet having the plurality of microprotrusions extending from a body surface proximal edge of the sheet for piercing the body surface, the sheet when in use being oriented in an approximately perpendicular relation to the body surface with the body surface proximal edge having the microprotrusions engaging the body surface.
Claim 20
Dependent Claim
22 words
The device of claim 18 , wherein the sheet has a configuration which defines a void for an agent-containing or agent-receiving reservoir.
Claim 21
Dependent Claim
29 words
The device of claim 18 , wherein the support contacts a second edge of the sheet, which second edge is opposite to the body surface proximal edge having microprotrusions.
Claim 22
Dependent Claim
31 words
A method of maintaining open agent-transmitting pathways through a body surface having the device of claim 1 positioned adjacent thereto, comprising periodically reapplying a body surface directed force to said device.
Claim 23
Dependent Claim
17 words
The method of claim 21 , wherein said reapplying causes said microprotrusions to repierce the body surface.
Claim 24
Dependent Claim
12 words
The method of claim 21 , wherein said force is applied manually.
Claim 25
Dependent Claim
14 words
The method of claim 21 , wherein the structural support comprises an annular member.
Claim 26
Dependent Claim
22 words
The method of claim 24 , wherein the annular member is a circular, square or rectangular annular member having a diagonal cross-member.
Claim 27
Dependent Claim
15 words
The method of claim 21 , wherein the structural support has a plurality of cross-members.
Claim 28
Dependent Claim
20 words
The method of claim 26 , wherein the plurality of cross-members intersect generally in the center of the structural support.
Claim 29
Dependent Claim
44 words
The method of claim 21 , wherein the structural support comprises: an outer annular member; an inner annular member having a diameter less than a diameter of the outer annular member; and the cross-member joins the inner annular member to the outer annular member.
Claim 30
Dependent Claim
25 words
The method of claim 21 , wherein the support has greater rigidity to a force applied perpendicular to the body surface than does the member.
Claim 31
Dependent Claim
30 words
The method of claim 21 , wherein the support is sufficiently rigid to deflect less than 300 μm under manually applied finger or hand pressing of the device against skin.
Claim 32
Dependent Claim
17 words
The method of claim 30 , wherein the support deflects less than 50 μm under said pressing.
Claim 33
Dependent Claim
29 words
The method of claim 21 , wherein the support is sufficiently incompressible to compress less than 250 μm under manually applied finger or hand pressing the device against skin.
Claim 34
Dependent Claim
17 words
The method of claim 32 , wherein the support compresses less than 50 μm under said pressing.
Claim 35
Dependent Claim
54 words
The method of claim 21 , wherein the member comprises a sheet which in use is oriented approximately parallel to the body surface, the sheet having a plurality of openings therein and the plurality of microprotrusions extending from a body proximal surface of the sheet, said microprotrusions being adapted to pierce the body surface.
Claim 36
Dependent Claim
19 words
The method of claim 21 , wherein the structural support defines a void for an agent-containing or agent-receiving reservoir.
Claim 37
Dependent Claim
47 words
The device of claim 1 , wherein the member has one or more peripheral edges and an interior portion surrounded by the one or more peripheral edges, wherein the structural support extends from the one or more peripheral edges and across the interior portion of the member.
Claim 38
Dependent Claim
20 words
The device of claim 8 , wherein the cross-members define a plurality of voids for an agent-containing or agent-receiving reservoir.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-11-26 | 2005-05-28 | 2005-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-11-26 | 2009-05-28 | 2009-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-11-26 | 2013-05-28 | 2013-11-27 | $7700.00 | Window Closed / Lapsed |