US6263237B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Techniques for treating anxiety disorders by brain stimulation and drug infusion
Assignee: Medtronic Inc
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Filing: 2000-02-14
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Granted: 2001-07-17
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Expires: 2020-02-14
Abstract
Abstract Techniques using one or more drugs and/or electrical stimulation for treating an anxiety disorder by means of an implantable signal generator and electrode and/or an implantable pump and catheter. A catheter is surgically implanted in the brain to infuse the drugs, and one or more electrodes may be surgically implanted in the brain to provide electrical stimulation.
Inventors
- 👤 Mark T. Rise
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 06:47
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61M2210/00; A61M2210/06; A61M2210/0693; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36082
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
97 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of: surgically implanting the catheter so that the discharge portion lies in a brain parenchyma; and, operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.
Claim 2
Independent Claim
97 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of: surgically implanting the catheter so that the discharge portion lies in a brain parenchyma; and, operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the step of surgically implanting comprises surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties.
Claim 4
Dependent Claim
43 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the anterior limb of the internal capsule.
Claim 5
Dependent Claim
42 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the head of the caudate nucleus.
Claim 6
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the cingulum fibers.
Claim 7
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter in the cingulate gyrus.
Claim 8
Dependent Claim
42 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the dorsal medial nucleus of thalamus.
Claim 9
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the locus ceruleus.
Claim 10
Dependent Claim
38 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the amygdyla.
Claim 11
Dependent Claim
40 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the dorsal raphe nucleus.
Claim 12
Dependent Claim
38 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the septum.
Claim 13
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the frontal cortex.
Claim 14
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the anterior thalamus.
Claim 15
Dependent Claim
39 words
The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the mammillary body.
Claim 16
Dependent Claim
19 words
The method of claim 1 further comprising the step of sensing physiological parameters of a heightened state of anxiety.
Claim 17
Dependent Claim
48 words
The method of claim 15 wherein the step of operating the pump includes the step of controlling the operation of the pump, in response to the step of sensing physiological parameters, to discharge a predetermined dosage of the one or more drugs when a physiological parameter is detected.
Claim 18
Independent Claim
155 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of a static device capable of storing and releasing the one or more drugs when implanted in the central nervous system, the method comprising the steps of: surgically implanting the static device so that the one or more drugs may be released in the central nervous system; providing an electrical signal generator and an implantable electrode having a proximal end and a stimulation portion, the proximal end of the electrode coupled to the signal generator; surgically implanting the electrode so that the stimulation portion may stimulate a site in a central nervous system chosen to have anxiolytic properties; operating the signal generator to stimulate the chosen site in the central nervous system; and, treating an anxiety disorder with the drug that may be released into the central nervous system and stimulating the chosen site in the central nervous system.
Claim 19
Independent Claim
155 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of a static device capable of storing and releasing the one or more drugs when implanted in the central nervous system, the method comprising the steps of: surgically implanting the static device so that the one or more drugs may be released in the central nervous system; providing an electrical signal generator and an implantable electrode having a proximal end and a stimulation portion, the proximal end of the electrode coupled to the signal generator; surgically implanting the electrode so that the stimulation portion may stimulate a site in a central nervous system chosen to have anxiolytic properties; operating the signal generator to stimulate the chosen site in the central nervous system; and, treating an anxiety disorder with the drug that may be released into the central nervous system and stimulating the chosen site in the central nervous system.
Claim 20
Dependent Claim
63 words
The method of claim 17 further comprising the steps of: sensing physiological parameters of a heightened state of anxiety; and wherein said step of operating the signal generator includes the step of operating the signal generator in response to the step of sensing physiological parameters, whereby the electrical signal produced by the signal generator is regulated in accordance with the physiological parameter detected.
Claim 21
Dependent Claim
24 words
The method of claim 18 wherein the step of sensing physiological parameters includes the step of implanting a sensor capable of sensing physiological parameters.
Claim 22
Independent Claim
101 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of: surgically implanting the catheter so that the discharge portion lies in an intrathecal space of a spinal cord; and, operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.
Claim 23
Independent Claim
101 words
A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of: surgically implanting the catheter so that the discharge portion lies in an intrathecal space of a spinal cord; and, operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-07-16 | 2005-01-15 | 2005-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-07-16 | 2009-01-15 | 2009-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-07-16 | 2013-01-15 | 2013-07-17 | $7700.00 | Window Closed / Lapsed |