US6046215A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibition of serotonin reuptake
Assignee: Eli Lilly and Co
•
Filing: 1998-07-30
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Granted: 2000-04-04
•
Expires: 2018-07-30
Abstract
Abstract This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
Inventors
- 👤 James E. Audia
- 👤 Daniel J. Koch
- 👤 Thomas E. Mabry
- 👤 Jeffrey S. Nissen
- 👤 Vincent P. Rocco
- 👤 Yao-Chang Xu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; A61K31/445; A61P; A61P25/00; A61P25/04; A61P43/00; C07D211/00; C07D211/04; C07D211/68; C07D333/00; C07D333/50; C07D333/52; C07D333/54; C07D333/58; C07D401/14; C07D409/00; C07D409/02; C07D409/04; C07D409/14; C07D417/00; C07D417/14
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
123 words
A compound of Formula II: ##STR13## A--B is --C═CH--; R 1 is H, halo, formyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, 4,5-dihydrothiazol-2-yl, cyano, nitro, carboxamido, trifluoromethyl or hydroxy; R 2 is H or halo; R 3 is H, C 1 -C 4 alkyl, (C 1 -C 4 alkylene)-aryl, or --CH 2 --Y--NR 7 R 8 ; R 6 is H or methyl; Y is --CH 2 -- or --C(O)--; R 7 is pyridinyl; and R 8 is H or --C(O)--(C 3 -C 6 cycloalkyl), provided that R 1 and R 2 may not both be H, and R 1 may not be C 1 -C 4 alkyl when R 2 is H, or pharmaceutically acceptable salts or hydrates thereof.
Claim 2
Dependent Claim
123 words
A compound of Formula II: ##STR13## A--B is --C═CH--; R 1 is H, halo, formyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, 4,5-dihydrothiazol-2-yl, cyano, nitro, carboxamido, trifluoromethyl or hydroxy; R 2 is H or halo; R 3 is H, C 1 -C 4 alkyl, (C 1 -C 4 alkylene)-aryl, or --CH 2 --Y--NR 7 R 8 ; R 6 is H or methyl; Y is --CH 2 -- or --C(O)--; R 7 is pyridinyl; and R 8 is H or --C(O)--(C 3 -C 6 cycloalkyl), provided that R 1 and R 2 may not both be H, and R 1 may not be C 1 -C 4 alkyl when R 2 is H, or pharmaceutically acceptable salts or hydrates thereof.
Claim 3
Dependent Claim
121 words
A compound of claim 1 which is of Formula III: ##STR14## where A--B is --C═CH--; R 1 is H, halo, formyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, cyano, nitro, carboxamido, trifluoromethyl or hydroxy; R 2 is H or halo; R 3 is H, C 1 -C 4 alkyl, (C 1 -C 4 alkylene)-aryl, or --CH 2 --Y--NR 7 R 8 ; R 6 is H or methyl; Y is --CH 2 -- or --C(O)--; R 7 is pyridinyl; and R 8 is H or --C(O)--(C 3 -C 6 cycloalkyl), provided that R 1 and R 2 may not both be H, and R 1 may not be C 1 -C 4 alkyl when R 2 is H.
Claim 4
Dependent Claim
16 words
A compound of claim 2 where R 3 is H or C 1 -C 4 alkyl.
Claim 5
Dependent Claim
20 words
A pharmaceutical formulation which comprises, in association with a pharmaceutically acceptable carrier, diluent or excipient, a compound of claim 1.
Claim 6
Dependent Claim
12 words
A formulation of claim 4, where the compound is of Formula III.
References Cited (Backward Citations)
JPS4856687A
Cited
DE2456246A1
Cited
US3974280A
Cited
US4196209A
Cited
US4195081A
Cited
US4278677A
Cited
US4232031A
Cited
FR2486081A2
Cited
US4324790A
Cited
US4333939A
Cited
US5409940A
Cited
US5532240A
Cited
US5714498A
Cited
WO1995033721A1
Cited
EP0708102A1
Cited
US5521197A
Cited
EP0714894A1
Cited
US5576321A
Cited
EP0747049A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-04-04 | 2003-10-04 | 2004-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-04-04 | 2007-10-04 | 2008-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-04-04 | 2011-10-04 | 2012-04-04 | $7700.00 | Window Closed / Lapsed |