Patent US6183409B1 successfully refreshed from Google Patents.
US6183409B1
Expired / Lapsed
US
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Soft x-ray emitting radioactive stent
Assignee: Best Medical International Inc
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Filing: 1999-02-09
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Granted: 2001-02-06
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Expires: 2019-02-09
Abstract
Abstract An implantable medical device according to the present invention comprises a body, such as a stent or a wire, and an isotope having a high neutron activation cross-section, such as 168 Yb or 124 Xe, ion-implanted onto the surface of the body. The use of isotopes having high neutron activation cross-sections allows a wider choice of substrates to be employed, including stainless steel, nickel, titanium, and alloys including these metals, because the time required for neutron activation of the device is reduced. A coating of high-density material may be incorporated to serve several useful purposes, including containment of undesirable beta particles from long-lived radioactive species, creation of a biologically inert surface, and enhancement of x-ray radiopacity to improve the visibility of an implanted medical device. The implantable medical devices of the present invention also comprise radioactive medical devices which include radioisotopes such as 169 Yb and 125 I.
Inventors
- 👤 Anthony J. Armini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:12
CPC Classifications
G; G21; G21G; G21G4/00; G21G4/04; G21G4/06; G21G4/08; A; A61; A61K; A61K41/00; A61K41/009; A61K51/00; A61K51/12; A61K51/1282; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2210/00; A61F2210/0095; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
45 words
A medical device comprising a body and at least one isotope associated with the body, wherein the isotope has a neutron activation cross-section of at least about 3000 barns, whereby thermal neutron activation of the isotope generates a therapeutically effective amount of a radioactive isotope.
Claim 2
Dependent Claim
45 words
A medical device comprising a body and at least one isotope associated with the body, wherein the isotope has a neutron activation cross-section of at least about 3000 barns, whereby thermal neutron activation of the isotope generates a therapeutically effective amount of a radioactive isotope.
Claim 3
Dependent Claim
26 words
The device of claim 1 , wherein said body comprises a material selected from the group consisting of organic polymers, ceramic oxides, metals, and metal alloys.
Claim 4
Dependent Claim
20 words
The device of claim 1 , further comprising a high-density coating applied to at least a portion of the body.
Claim 5
Dependent Claim
20 words
The device of claim 3 , further comprising an adhesion coating disposed between said body and said high density coating.
Claim 6
Dependent Claim
29 words
A medical device comprising a body and 168 Yb associated with said body, whereby thermal neutron activation of the 168 Yb generates a therapeutically effective amount of 169 Yb.
Claim 7
Dependent Claim
29 words
A medical device comprising a body and 168 Yb associated with said body, whereby thermal neutron activation of the 168 Yb generates a therapeutically effective amount of 169 Yb.
Claim 8
Dependent Claim
12 words
The device of claim 5 , wherein the 168 Yb is ion-implanted.
Claim 9
Dependent Claim
25 words
The device of claim 5 , wherein the amount of ytterbium associated with the body is between about 1×10 15 and about 5×10 17 atoms.
Claim 10
Dependent Claim
24 words
The device of claim 5 , wherein the concentration of ytterbium associated with the body is at least about 1×10 16 atoms/cm 2 .
Claim 11
Dependent Claim
13 words
A medical device comprising a body and 124 Xe associated with said body.
Claim 12
Dependent Claim
13 words
A medical device comprising a body and 124 Xe associated with said body.
Claim 13
Dependent Claim
12 words
The device of claim 9 , wherein the 124 Xe is ion-implanted.
Claim 14
Dependent Claim
15 words
The device of claim 9 , wherein said body comprises stainless steel, titanium, or nitinol.
Claim 15
Dependent Claim
16 words
The device of claim 9 , wherein said body comprises rhodium, palladium, or a palladium alloy.
Claim 16
Dependent Claim
30 words
The device of claim 9 , wherein the amount of 124 Xe associated with the body is between about 1×10 17 and about 5×10 18 atoms per centimeter of length.
References Cited (Backward Citations)
US3351049A
Cited
US4323055A
Cited
US4881938A
Cited
US5302369A
Cited
US4776337B1
Cited
US4776337A
Cited
US4733665C2
Cited
US4739762B1
Cited
US4733665B1
Cited
US4739762A
Cited
US4733665A
Cited
US5030194A
Cited
US4946435A
Cited
EP0593136A1
Cited
US5176617A
Cited
US5059166A
Cited
US5342283A
Cited
US5364336A
Cited
US5382261A
Cited
US5656036A
Cited
US5674177A
Cited
US5632771A
Cited
US5868757A
Cited
US5607442A
Cited
US5919126A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-02-06 | 2004-08-07 | 2005-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-02-06 | 2008-08-07 | 2009-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-02-06 | 2012-08-07 | 2013-02-06 | $7700.00 | Window Closed / Lapsed |