US6162247A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular graft impregnated with a heparin-containing collagen sealant
Assignee: Maquet Cardiovascular LLC
•
Filing: 1998-12-21
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Granted: 2000-12-19
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Expires: 2018-12-21
Abstract
Abstract A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without causing the agglutination of collagen from the dispersion. The impregnation of collagen and heparin within the prosthesis effectively prevents blood loss and thrombus formation after implantation of the prosthesis.
Inventors
- 👤 Kevin Weadock
- 👤 David J. Lentz
- 👤 Jack Tant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:35
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
65 words
A method of sealing a synthetic vascular prosthesis with a collagen-heparin composition, comprising the steps of: preparing a stable collagen-heparin dispersion at alkaline pH within a range from about 9 to about 11, wherein said dispersion is maintained within a pH range of from about 9 to about 11; and applying said dispersion to said prosthesis to effectuate sealing and impart enhanced antithrombogenic properties thereto.
Claim 2
Independent Claim
65 words
A method of sealing a synthetic vascular prosthesis with a collagen-heparin composition, comprising the steps of: preparing a stable collagen-heparin dispersion at alkaline pH within a range from about 9 to about 11, wherein said dispersion is maintained within a pH range of from about 9 to about 11; and applying said dispersion to said prosthesis to effectuate sealing and impart enhanced antithrombogenic properties thereto.
Claim 3
Dependent Claim
15 words
A method as defined by claim 1, wherein said prosthesis is impregnated with said dispersion.
Claim 4
Dependent Claim
15 words
A method as defined by claim 1, wherein said prosthesis is coated with said dispersion.
Claim 5
Dependent Claim
19 words
A method as defined by claim 1, wherein the collagen-heparin dispersion is prepared at a pH of about 10.
Claim 6
Dependent Claim
27 words
A method as defined by claim 1, wherein the collagen-heparin dispersion has a ratio of heparin to collagen within a range of about 1:100 to about 1:1.
Claim 7
Dependent Claim
18 words
A synthetic vascular prosthesis as defined by claim 1, wherein the collagen applied to said prosthesis is crosslinked.
Claim 8
Dependent Claim
81 words
A collagen-heparin impregnated vascular prosthesis including a synthetic tubular substrate with an extraluminal and an intraluminal surface, prepared by a process comprising the steps of: preparing a stable collagen-heparin dispersion at alkaline pH within a range from about 9 to about 11, wherein said dispersion is maintained within a pH range of from about 9 to about 11; and applying said dispersion to at least said intraluminal surface of said tubular substrate to provide an improved antithrombogenic seal to said prosthesis.
Claim 9
Dependent Claim
81 words
A collagen-heparin impregnated vascular prosthesis including a synthetic tubular substrate with an extraluminal and an intraluminal surface, prepared by a process comprising the steps of: preparing a stable collagen-heparin dispersion at alkaline pH within a range from about 9 to about 11, wherein said dispersion is maintained within a pH range of from about 9 to about 11; and applying said dispersion to at least said intraluminal surface of said tubular substrate to provide an improved antithrombogenic seal to said prosthesis.
Claim 10
Dependent Claim
23 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes applying said dispersion to a three-dimensional braided structure.
Claim 11
Dependent Claim
22 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes applying said dispersion to a knitted substrate.
Claim 12
Dependent Claim
22 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes applying said dispersion to a woven substrate.
Claim 13
Dependent Claim
30 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes supplying said dispersion in a ratio of collagen to heparin of not less than one.
Claim 14
Dependent Claim
25 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes crosslinking said collagen after it is applied to said prosthesis.
Claim 15
Dependent Claim
23 words
A synthetic collagen-heparin impregnated vascular prosthesis as defined by claim 7, wherein said process includes providing said dispersion at pH of approximately 10.
Claim 16
Independent Claim
93 words
A method of preparing a stable collagen-heparin dispersion that is useful for treating implantable synthetic prostheses, comprising the steps of: mixing collagen and water to prepare a collagen dispersion in which the percentage of collagen is 2% by weight; adding sodium hydroxide in sufficient amounts to said dispersion to raise the pH to an alkaline pH level within a pH range of about 9 to 11 to avoid collagen precipitation; and adding heparin to said dispersion in an amount in a ratio of heparin to collagen of from about 1:100 to about 1.1.
Claim 17
Independent Claim
93 words
A method of preparing a stable collagen-heparin dispersion that is useful for treating implantable synthetic prostheses, comprising the steps of: mixing collagen and water to prepare a collagen dispersion in which the percentage of collagen is 2% by weight; adding sodium hydroxide in sufficient amounts to said dispersion to raise the pH to an alkaline pH level within a pH range of about 9 to 11 to avoid collagen precipitation; and adding heparin to said dispersion in an amount in a ratio of heparin to collagen of from about 1:100 to about 1.1.
References Cited (Backward Citations)
US3106483A
Cited
DE1494939A1
Cited
US3425418A
Cited
DE1491218A1
Cited
US3272204A
Cited
US3479670A
Cited
FR1601323A
Cited
FR2029155A5
Cited
US3953566A
Cited
US3808113A
Cited
US3688317A
Cited
DE2119004A1
Cited
US3805301A
Cited
US3928653A
Cited
US4355426A
Cited
FR2318189A1
Cited
US4280954A
Cited
DE2601289A1
Cited
US4047252A
Cited
US4164254A
Cited
US4113912A
Cited
US4193138A
Cited
US4349467A
Cited
US4229838A
Cited
US4167045A
Cited
EP0000949A1
Cited
US4219520A
Cited
DE2843963A1
Cited
US4332035A
Cited
US4713070A
Cited
US4254180A
Cited
US4416028A
Cited
GB2092944A
Cited
WO1983000574A1
Cited
WO1983003536A1
Cited
US4921495A
Cited
US5034265A
Cited
US5197977A
Cited
US5108424A
Cited
US4814120A
Cited
US4837024A
Cited
US4841962A
Cited
US5037377A
Cited
US4747848A
Cited
US4833200A
Cited
US5061281A
Cited
US4822361A
Cited
US4902290A
Cited
US4784659A
Cited
US4911713A
Cited
US5131907A
Cited
EP0241838A2
Cited
EP0246638A2
Cited
US4804381A
Cited
US5061276A
Cited
US4842275A
Cited
US5024671A
Cited
US4973609A
Cited
US5110527A
Cited
US5141522A
Cited
WO1992003764A1
Cited
US5178630A
Cited
US5118524A
Cited
US5120833A
Cited
US5192310A
Cited
US5851230A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-19 | 2004-06-19 | 2004-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-19 | 2008-06-19 | 2008-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-19 | 2012-06-19 | 2012-12-19 | $7700.00 | Window Closed / Lapsed |