Patent US6149624A successfully refreshed from Google Patents.
US6149624A
Expired / Lapsed
US
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Apparatus and method for the rapid induction of hypothermic brain preservation
Assignee: Individual
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Filing: 1998-02-05
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Granted: 2000-11-21
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Expires: 2018-02-05
Abstract
Abstract Apparatus and method for using a cooled fluid to be introduced into the lungs as a heat exchange which as a result of the circulatory system of the body, lowers the temperature of the brain as well as the temper of the body in general. In instances where cardiopulmonary arrest occurs and CPR is delayed due to the clinical setting in which the arrest takes place, the rapid induction of brain hypothermia by liquid pulmonary lavage secures valuable time for the subsequent application of CPR techniques. The method can be used on any elective hypothermic surgery.
Inventors
- 👤 Richard Houston McShane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:12
CPC Classifications
A; A61; A61F; A61F7/00; A61F7/12; A61M; A61M3/00; A61M3/02; A61M3/0233; A61M3/0254; A61M3/0258; A61M16/00; A61M16/0054; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3606; A61M2210/00; A61M2210/06; A61M2210/0693; A61M2210/10; A61M2210/1025; A61M2210/1039; A61M3/0229
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
223 words
An assembly suitable for inducing rapid hypothermic brain preservation using a liquid pulmonary lavage comprising: a fluid reservoir suitable for storage of a liquid pulmonary lavage; heat exchanger means suitable for cooling said liquid pulmonary lavage; means connecting said fluid reservoir and said heat exchanger means; means associated with said fluid reservoir for circulating said liquid pulmonary lavage and connected to, a first flexible catheter extending from and connected at its proximal end to said heat exchanger means and having a distal end suitable for dispensing said cooled liquid pulmonary lavage in a subject's tracheobronchial tree; a second flexible catheter insertable in said subject's tracheobronchial tree positioned substantially parallel to said first catheter and having a closed distal end and a proximal end, and having a plurality of openings adjacent said proximal end of said catheter, said openings providing access to the interior of said catheter; said proximal end of said second catheter connected to an effluent reservoir; said effluent reservoir containing means for creating low pressure in said second catheter to withdraw said liquid pulmonary lavage effluent from the subject's tracheobronchial tree; said effluent reservoir having means to filter and purify said liquid pulmonary lavage effluent to form a recycled liquid pulmonary lavage effluent; means connecting said effluent reservoir and said fluid reservoir to deliver said recycled liquid pulmonary lavage effluent thereto.
Claim 2
Dependent Claim
223 words
An assembly suitable for inducing rapid hypothermic brain preservation using a liquid pulmonary lavage comprising: a fluid reservoir suitable for storage of a liquid pulmonary lavage; heat exchanger means suitable for cooling said liquid pulmonary lavage; means connecting said fluid reservoir and said heat exchanger means; means associated with said fluid reservoir for circulating said liquid pulmonary lavage and connected to, a first flexible catheter extending from and connected at its proximal end to said heat exchanger means and having a distal end suitable for dispensing said cooled liquid pulmonary lavage in a subject's tracheobronchial tree; a second flexible catheter insertable in said subject's tracheobronchial tree positioned substantially parallel to said first catheter and having a closed distal end and a proximal end, and having a plurality of openings adjacent said proximal end of said catheter, said openings providing access to the interior of said catheter; said proximal end of said second catheter connected to an effluent reservoir; said effluent reservoir containing means for creating low pressure in said second catheter to withdraw said liquid pulmonary lavage effluent from the subject's tracheobronchial tree; said effluent reservoir having means to filter and purify said liquid pulmonary lavage effluent to form a recycled liquid pulmonary lavage effluent; means connecting said effluent reservoir and said fluid reservoir to deliver said recycled liquid pulmonary lavage effluent thereto.
Claim 3
Dependent Claim
53 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 1 further including the liquid pulmonary lavage in a dosage amount to be instilled into said subject according to the formula 25 cc of said liquid pulmonary lavage for each kilogram of the subject's body weight.
Claim 4
Dependent Claim
28 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 2, wherein said liquid pulmonary lavage comprises an isotonic saline solution.
Claim 5
Dependent Claim
27 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 2, wherein said liquid pulmonary lavage comprises a hypertonic solution.
Claim 6
Dependent Claim
27 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 2, wherein said liquid pulmonary lavage comprises a hypotonic solution.
Claim 7
Dependent Claim
34 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 2, wherein said liquid pulmonary lavage comprises a nonelectrolyte which is isotonic with human red blood cells.
Claim 8
Dependent Claim
29 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 2, wherein said liquid pulmonary lavage comprises a perfluorocarbon and a surfactant.
Claim 9
Dependent Claim
26 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 7, wherein said surfactant is based upon a phospholipid.
Claim 10
Dependent Claim
26 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 8, wherein said phospholipid is at least one glycerophospholipid.
Claim 11
Dependent Claim
42 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 9, wherein said at least one glycerophospholipid is selected from the group consisting of phosphatidic acid, diacylglycerols joined to phosphoric acid through an ester link.
Claim 12
Dependent Claim
36 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 9, wherein said at least one glycerophospholipid is selected from the group consisting of phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols and phosphatidylserine.
Claim 13
Dependent Claim
66 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 11, wherein said dosage comprises 20% to 30% perfluorocarbon, between about 1% and 3% w/v surfactant, an oncontic agent, salts for adjusting the osmotic pressure selected from the group consisting of NaCl, KCl, MgCl 2 , CaCl 2 , NaH 2 PO 4 , NaHCO 3 buffer and water.
Claim 14
Dependent Claim
49 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 12, wherein said perfluorocarbon is a mixture of seven parts perfluorodecahydronaphthalene, 3 parts perfluorotripropylamine, 2.7% a blend of polymers of polyoxypropylene with polyoxyethylene predominately at each end thereof, and about 0.4% phospholipid.
Claim 15
Dependent Claim
35 words
The assembly suitable for inducing rapid hypothermic brain preservation using the liquid pulmonary lavage defined in claim 13, wherein said phospholipid is made from egg yolk to form a membrane coating for an emulsion formed.
Claim 16
Independent Claim
259 words
A method for the rapid induction of brain preservation comprising: passing a liquid suitable for use as a pulmonary lavage from a reservoir through heat exchanger means suitable for cooling said liquid pulmonary lavage into a first flexible catheter extending from and connected at its proximal end to said heat exchanger means and having an open distal end suitable for dispensing said cooled liquid pulmonary lavage; inserting said distal end into a subject's tracheobronchial tree and passing said liquid pulmonary lavage into said tracheobronchial tree so that said cooled liquid is pumped to the deepest part of the subject's pulmonary tree with the result that the blood circulating through the lungs is cooled which flows to the heart and the brain, thereby cooling the brain; said liquid pulmonary lavage being warmed to a liquid pulmonary lavage effluent; concurrently removing said liquid pulmonary effluent from said subject's tracheobronchial tree via a second flexible catheter which is inserted into said subject's tracheobronchial tree substantially parallel to said first catheter and having a closed distal end and a proximal end, and having a plurality of openings adjacent said proximal end of said catheter, said openings providing access to the interior of said catheter through which said liquid pulmonary lavage effluent flows into an effluent reservoir; said effluent reservoir containing means for creating low pressure to withdraw said liquid pulmonary lavage effluent from the subject's tracheobronchial tree; filtering and purifying said liquid pulmonary lavage effluent to form a recycled liquid pulmonary lavage in said effluent reservoir and passing said product to said reservoir.
Claim 17
Independent Claim
259 words
A method for the rapid induction of brain preservation comprising: passing a liquid suitable for use as a pulmonary lavage from a reservoir through heat exchanger means suitable for cooling said liquid pulmonary lavage into a first flexible catheter extending from and connected at its proximal end to said heat exchanger means and having an open distal end suitable for dispensing said cooled liquid pulmonary lavage; inserting said distal end into a subject's tracheobronchial tree and passing said liquid pulmonary lavage into said tracheobronchial tree so that said cooled liquid is pumped to the deepest part of the subject's pulmonary tree with the result that the blood circulating through the lungs is cooled which flows to the heart and the brain, thereby cooling the brain; said liquid pulmonary lavage being warmed to a liquid pulmonary lavage effluent; concurrently removing said liquid pulmonary effluent from said subject's tracheobronchial tree via a second flexible catheter which is inserted into said subject's tracheobronchial tree substantially parallel to said first catheter and having a closed distal end and a proximal end, and having a plurality of openings adjacent said proximal end of said catheter, said openings providing access to the interior of said catheter through which said liquid pulmonary lavage effluent flows into an effluent reservoir; said effluent reservoir containing means for creating low pressure to withdraw said liquid pulmonary lavage effluent from the subject's tracheobronchial tree; filtering and purifying said liquid pulmonary lavage effluent to form a recycled liquid pulmonary lavage in said effluent reservoir and passing said product to said reservoir.
Claim 18
Dependent Claim
28 words
The method defined in claim 15 wherein the total dose of said fluid instilled into said subject is 25 cc of said fluid per kilogram of body weight.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-11-21 | 2004-05-22 | 2004-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-11-21 | 2008-05-22 | 2008-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-11-21 | 2012-05-22 | 2012-11-21 | $7700.00 | Window Closed / Lapsed |