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US6123902A
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US
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Device for highly sensitive magnetic detection of analytes
Assignee: Physikalisch-Technische Bundesanstalt
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Filing: 1997-03-26
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Granted: 2000-09-26
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Expires: 2017-03-26
Abstract
Abstract An apparatus for the qualitative and/or quantitative measurement of analytes, in particular in biological samples by means of receptor ligand binding and having a magnetizing device for the production of a magnetic field at the location of the sample and with a detection device for measurement of magnetic properties of the sample is characterized in that the magnetizing device is spatially disposed with respect to the detection device in such a fashion that the magnetic field produced by the magnetization device at the location of the magnetization is attenuated by at least a factor of 10, and preferentially by a factor of 1000 or more, at the location occupied by the sample during the measurement, or in that a switching device is provided for which, throughout a predetermined time duration and in particular during the measurement phase of the detection device can switch-off the magnetic field of the magnetizing device at the location of the sample. In this fashion new types of measurements for magnetorelaxometric detection of analytes or for the detection of analytes by means of remanence measurements can be carried out in a routine and economical fashion in vitro or in vivo.
Inventors
- 👤 Hans Koch
- 👤 Hartmut Matz
- 👤 Roman Kotitz
- 👤 Dietmar Drung
- 👤 Lutz Trahms
- 👤 Werner Weitschies
- 👤 Wolfhard Semmler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:38
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; G01N33/54333; G01N35/00; G01N35/0098; Y; Y10; Y10S; Y10S505/00; Y10S505/825; Y10S505/842; Y10S505/843; Y10S505/845; Y10S505/846
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
71 words
An apparatus for the measurement of analytes in a sample by means of receptor ligand bonding, the apparatus comprising: a detection device for measurement of magnetic properties of a sample during a measurement time; a magnetizing device for producing a magnetic field at the sample; and means for reducing a magnetic field strength of said magnetic field at the sample by a factor of at least 10 during said measurement time.
Claim 2
Independent Claim
71 words
An apparatus for the measurement of analytes in a sample by means of receptor ligand bonding, the apparatus comprising: a detection device for measurement of magnetic properties of a sample during a measurement time; a magnetizing device for producing a magnetic field at the sample; and means for reducing a magnetic field strength of said magnetic field at the sample by a factor of at least 10 during said measurement time.
Claim 3
Dependent Claim
12 words
The apparatus of claim 1, wherein said factor is at least 1000.
Claim 4
Dependent Claim
19 words
The apparatus of claim 1, wherein said reducing means comprise means for moving the sample during said measurement time.
Claim 5
Dependent Claim
35 words
The apparatus of claim 1, wherein said reducing means comprise a circuit for switching-off said magnetic field at the sample for a predetermined time, and a device for moving the sample during said measurement time.
Claim 6
Dependent Claim
50 words
The apparatus of claim 1, wherein said reducing means comprises a switching device for switching-off said magnetic field for a predetermined length of time, said switching device having a first member to switch-on and switch-off said magnetic field and having a second member for switching-on and switching-off said detection device.
Claim 7
Dependent Claim
19 words
The apparatus of claim 5, wherein said first and said second members can be switched independently of each other.
Claim 8
Dependent Claim
24 words
The apparatus of claim 5, wherein said first member can be switched with a predetermined fixed time correlation with respect to said second member.
Claim 9
Dependent Claim
26 words
The apparatus of claim 5, wherein said first member can reduce predetermined field amplitudes and field polarities of said magnetic field produced by said magnetizing device.
Claim 10
Dependent Claim
29 words
The apparatus of claim 8, wherein said first member for producing predetermined amplitude time dependences and predetermined polarity time dependences of said magnetic field produced by said magnetizing device.
Claim 11
Dependent Claim
19 words
The apparatus of claim 1, wherein said detection device comprises means for measurement of a magnetization of the sample.
Claim 12
Dependent Claim
14 words
The apparatus of claim 10, wherein said detection device comprises means for magneto-relaxometric detection.
Claim 13
Dependent Claim
23 words
The apparatus of claim 1, wherein said detection device comprises means for measurement of a binding remanence of the analyte in the sample.
Claim 14
Dependent Claim
17 words
The apparatus of claim 1, wherein said detection device comprises at least one superconducting quantum interference device.
Claim 15
Dependent Claim
15 words
The apparatus of claim 1, wherein said detection device comprises at least one induction coil.
Claim 16
Dependent Claim
14 words
The apparatus of claim 1, further comprising means for electronic suppression of interfering signals.
Claim 17
Dependent Claim
20 words
The apparatus of claim 15, wherein said means for electronic suppression of interfering signals comprises a unit for adaptive filtering.
Claim 18
Dependent Claim
42 words
The apparatus of claim 1, further comprising means for vector measurement of interfering fields and means connected thereto for appropriate compensation of at least one of a signal measured by said detection device and said magnetic field produced by said magnetizing device.
Claim 19
Dependent Claim
11 words
The apparatus of claim 1, wherein the sample for in-vivo measurements.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-26 | 2004-03-27 | 2004-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-26 | 2008-03-27 | 2008-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-26 | 2012-03-27 | 2012-09-26 | $7700.00 | Window Closed / Lapsed |