Abstract Devices, packaging and methodology for efficiently and repeatably creating aerosolized bursts of an analgesic (e.g., narcotic) containing formulation are disclosed. Devices are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. The release point is automatically determined either mechanically or, more preferably calculated by a microprocessor which receives data from a sensor making it possible to determine inspiratory flow rate and inspiratory volume. The device is loaded with a cassette comprised of an outer housing which holds a package of individual disposable collapsible containers of an analgesic containing formulation for systemic delivery. Actuation of the device forces analgesic formulation through a porous membrane of the container which membrane has pores having a diameter in the range of about 0.25 to 3.0 microns, preferably 0.25 to 1.5 microns. The porous membrane is positioned in alignment with a surface of a channel through which a patient inhales air. The flow profile of air moving through the channel is such that the flow at the surface of the channel is less than the flow rate at the center of the channel.
A method of managing the pain of a patient, comprising: repeatedly administering to the patient an aerosolized formulation of a narcotic drug wherein the aerosolized formulation is repeatedly administered to the patient at substantially the same inspiratory flow rate and inspiratory volume; and measuring the patient's respiratory rate; and continually adjusted the amount of drug administered to the patient based on the patient's respiratory rate.
Claim 2
Independent Claim
65 words
A method of managing the pain of a patient, comprising: repeatedly administering to the patient an aerosolized formulation of a narcotic drug wherein the aerosolized formulation is repeatedly administered to the patient at substantially the same inspiratory flow rate and inspiratory volume; and measuring the patient's respiratory rate; and continually adjusted the amount of drug administered to the patient based on the patient's respiratory rate.
Claim 3
Dependent Claim
48 words
The method as claimed in claim 1, wherein the narcotic drug is delivered to the patient when the patient's inspiratory volume is in the range of about 0.1 to about 2 liters/second and the patient's inspiratory volume is in the range of about 0.15 to about 0.8 liters.