US6084102A
Expired / Lapsed
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Covalently linked oligonucleotide minor grove binder conjugates
Assignee: DRUG ROYALTY TRUST 9
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Filing: 1998-08-27
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Granted: 2000-07-04
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Expires: 2018-08-27
Abstract
Abstract Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids thereof. The covalently bound oligonucleotide minor groove binder conjugates strongly bind to the target sequence of the complementary strand.
Inventors
- 👤 Igor V. Kutyavin
- 👤 Eugeny A. Lukhtanov
- 👤 Howard B. Gamper
- 👤 Rich B. Meyer, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:54
CPC Classifications
C; C07; C07H; C07H21/00; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/34; C07D403/00; C07D403/02; C07D403/12; C07D487/00; C07D487/02; C07D487/04; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/073; C07H19/16; C07H19/173; C07H19/23; C07H21/04; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
18 words
A compound of the formula ##STR19## where R is CONH 2 or t-butyloxy-carbonyl, and R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 2
Dependent Claim
18 words
A compound of the formula ##STR19## where R is CONH 2 or t-butyloxy-carbonyl, and R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 3
Dependent Claim
13 words
A compound in accordance with claim 1 where R is CONH 2 .
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 where R is t-butyloxycarbonyl.
Claim 5
Dependent Claim
18 words
A compound of the formula ##STR20## where R is CONH 2 or t-butyloxycarbonyl, and R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 6
Dependent Claim
18 words
A compound of the formula ##STR20## where R is CONH 2 or t-butyloxycarbonyl, and R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 7
Dependent Claim
13 words
A compound in accordance with claim 4 where R is CONH 2 .
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 4 where R is t-butyloxycarbonyl.
Claim 9
Dependent Claim
11 words
A compound of the formula ##STR21## where R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 10
Dependent Claim
11 words
A compound of the formula ##STR21## where R 1 is 2,3,5,6-tetrafluorophenyloxy.
Claim 11
Dependent Claim
22 words
A compound of the formula ##STR22## where CPG represent a solid phase support, and Tr represents a triphenylmethyl or substituted triphenylmethyl group.
Claim 12
Dependent Claim
22 words
A compound of the formula ##STR22## where CPG represent a solid phase support, and Tr represents a triphenylmethyl or substituted triphenylmethyl group.
Claim 13
Dependent Claim
13 words
A compound in accordance with claim 8 where Tr represents a dimethoxytriphenylmethyl group.
Claim 14
Dependent Claim
30 words
A compound of the formula ##STR23## where n is an integer from 1 and 5; R 1 is H, t-butyloxycarbonyl or tBoc-NH(CH 2 ) 6 CO where tBoc represent t-butyloxycarbonyl.
Claim 15
Dependent Claim
30 words
A compound of the formula ##STR23## where n is an integer from 1 and 5; R 1 is H, t-butyloxycarbonyl or tBoc-NH(CH 2 ) 6 CO where tBoc represent t-butyloxycarbonyl.
Claim 16
Dependent Claim
11 words
A compound in accordance with claim 10 where n is 1.
Claim 17
Dependent Claim
11 words
A compound in accordance with claim 10 where n is 5.
Claim 18
Dependent Claim
12 words
A compound in accordance with claim 10 where R 1 is t-butyloxy-carbonyl.
Claim 19
Dependent Claim
12 words
A compound in accordance with claim 10 where R 1 is H.
Claim 20
Dependent Claim
16 words
A compound in accordance with claim 10 where R 1 is t-Boc-NH(CH 2 ) 6 CO--.
Claim 21
Dependent Claim
12 words
A compound in accordance with claim 12 where R 1 is H.
Claim 22
Dependent Claim
16 words
A compound in accordance with claim 12 where R 1 is tBOC-NH(CH 2 ) 6 CO.
References Cited (Backward Citations)
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Cited
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Cited
US5419966A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-07-04 | 2004-01-03 | 2004-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-07-04 | 2008-01-03 | 2008-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-07-04 | 2012-01-03 | 2012-07-04 | $7700.00 | Window Closed / Lapsed |