Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
47 words
An improved method of angioplasty or cardiac catheterization in which said improvement comprises: administering a therapeutically effective amount of a lipid acceptor to a subject, said lipid acceptor being selected from the group consisting of large liposomes comprised of phospholipids substantially free of sterol and small acceptors.
Claim 2
Dependent Claim
47 words
An improved method of angioplasty or cardiac catheterization in which said improvement comprises: administering a therapeutically effective amount of a lipid acceptor to a subject, said lipid acceptor being selected from the group consisting of large liposomes comprised of phospholipids substantially free of sterol and small acceptors.
Claim 3
Dependent Claim
24 words
The method in accordance with claim 1 in which said administration of said lipid acceptor occurs at or over an effective period of time.
Claim 4
Dependent Claim
36 words
The method in accordance with claim 2 in which said effective period of time is in the range of about 1 minute to about two years from the time of said angioplasty or said cardiac catheterization.
Claim 5
Dependent Claim
24 words
The method in accordance with claim 1 in which said administration of said lipid acceptor occurs simultaneously with said angioplasty or said cardiac catheterization.
Claim 6
Dependent Claim
11 words
The method of claim 1 further comprising assessing a vascular function.
Claim 7
Dependent Claim
60 words
The method of claim 5 in which the step of assessing a vascular function is selected from the group consisting of measuring blood flow in a carotid artery, measuring blood flow in a lower limb, measuring blood flow in a vessel using ultrasound, measuring blood flow using an MRI, measuring blood flow using a radioisotope tracer, and measuring blood viscosity.
Claim 8
Dependent Claim
15 words
The method of claim 1 in which said angioplasty is performed on a blocked vessel.
Claim 9
Dependent Claim
23 words
The method of claim 7 in which said blocked vessel is selected from the group consisting a femoral vessel and a coronary vessel.
Claim 10
Dependent Claim
12 words
The method of claim 1 in which said angioplasty comprises carotid endarterectomy.
Claim 11
Dependent Claim
16 words
The method of claim 1 in which said angioplasty comprises surgery to relieve a carotid obstruction.
Claim 12
Dependent Claim
20 words
The method of claim 1 in which said angioplasty comprises a mechanical or a surgical intervention to improve blood flow.
Claim 13
Dependent Claim
16 words
The method in accordance with claim 11 in which said intervention comprises placement of a stent.
Claim 14
Dependent Claim
22 words
The method of claim 1 in which said angioplasty comprises coronary angioplasty, femoral angioplasty, and a surgery to relieve a carotid obstruction.
Claim 15
Dependent Claim
19 words
The method in accordance with claim 1 in which said large liposomes have diameters larger than about 120 nm.
Claim 16
Dependent Claim
19 words
The method in accordance with claim 1 in which the large liposomes have diameters larger than about 125 nm.
Claim 17
Dependent Claim
19 words
The method in accordance with claim 1 in which the large liposomes have diameters larger than about 150 nm.
Claim 18
Dependent Claim
19 words
The method in accordance with claim 1 in which the large liposomes have diameters larger than about 160 nm.
Claim 19
Dependent Claim
19 words
The method in accordance with claim 1 in which the large liposomes have diameters larger than about 175 nm.
Claim 20
Dependent Claim
19 words
The method in accordance with claim 1 in which the large liposomes have diameters larger than about 200 nm.
Claim 21
Dependent Claim
21 words
The method of claim 1 in which said large liposomes have an unesterified cholesterol to phospholipid molar ratio below about 1:10.
Claim 22
Dependent Claim
12 words
The method of claim 1 in which said large liposomes comprise POPC.
Claim 23
Dependent Claim
15 words
The method of claim 1 in which the large liposomes are given in repeated doses.
Claim 24
Dependent Claim
23 words
The method of claim 1 in which said phospholipids are given in a daily dosage of less than about 600 mg/kg body weight.
Claim 25
Dependent Claim
12 words
The method of claim 23 in which said dosage is administered repeatedly.
Claim 26
Dependent Claim
32 words
The method in accordance with claim 1 in which the large liposomes are made of phospholipids selected from the group consisting of phosphatidyl choline, phosphatidyl glycerol, palmitoyl-oleoyl phosphatidyl choline, and combinations thereof.
Claim 27
Dependent Claim
14 words
The method in accordance with claim 1 further comprising administering a lipid lowering drug.
Claim 28
Dependent Claim
15 words
The method in accordance with claim 1 further comprising administering a drug that inhibits restenosis.
Claim 29
Dependent Claim
18 words
The method in accordance with claim 1 further comprising inserting a device in a subject that inhibits restenosis.
Claim 30
Dependent Claim
14 words
The method in accordance with claim 28 in which said device comprises a stent.