US5556637A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water containing liposome system
Assignee: A Natterman und Cie GmbH
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Filing: 1995-01-11
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Granted: 1996-09-17
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Expires: 2015-01-11
Abstract
Abstract An aqueous liposome system which contains at least one phospholipid and selectively a non-toxic organic solvent. In addition to the at least one phospholipid the liposome system contains at least one phospholipidic charge carrier.
Inventors
- 👤 J org Hager
- 👤 Manfred D urr
- 👤 Ernst L unebach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
90 words
A liposome composition consisting essentially of at least one uncharged phospholipid, said uncharged phospholipid comprising at least 90% by weight of phosphatidylcholine, at least one negatively charged phospholipid, said negatively charged phospholipid being a salt of a phosphatidylglycerol, a pharmaceutically active substance and water forming an aqueous phase for said liposome composition, wherein the mass ratio of the uncharged phospholipid to the charged phospholipid is in the range of 100:1 to about 400: 1, and the total phospholipid content of the liposome composition is between 0.50 and 20% by weight.
Claim 2
Dependent Claim
90 words
A liposome composition consisting essentially of at least one uncharged phospholipid, said uncharged phospholipid comprising at least 90% by weight of phosphatidylcholine, at least one negatively charged phospholipid, said negatively charged phospholipid being a salt of a phosphatidylglycerol, a pharmaceutically active substance and water forming an aqueous phase for said liposome composition, wherein the mass ratio of the uncharged phospholipid to the charged phospholipid is in the range of 100:1 to about 400: 1, and the total phospholipid content of the liposome composition is between 0.50 and 20% by weight.
Claim 3
Dependent Claim
27 words
The liposome composition of claim 1 wherein the mass ratio of the phospholipid to the charged phospholipid is in the range of about 100:1 to about 200:1.
Claim 4
Dependent Claim
19 words
The liposome composition of claim 1 wherein said charged phospholipid is a sodium or ammonium salt of a phosphatidylglycerol.
Claim 5
Dependent Claim
17 words
The liposome composition of claim 1 wherein said charged phospholipid is a salt of dimyristoylphosphatidylglycerol or dipalmitoylphosphatidylglycerol.
Claim 6
Dependent Claim
16 words
The liposome composition of claim 1 wherein said charged phospholipid is a salt of soya phosphatidylglycerol.
Claim 7
Dependent Claim
33 words
The liposome composition of claim 1 wherein said pharmaceutically active substance is selected from the group consisting of doxorubicin.HCl, pentamidine, a pentamidine salt, rosemarinic acid, a salt of rosemarinic acid, and dextran sulfate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-09-17 | 2000-03-18 | 2000-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-09-17 | 2004-03-18 | 2004-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-09-17 | 2008-03-18 | 2008-09-17 | $7700.00 | Window Closed / Lapsed |