US6041252A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery system and method
Assignee: Ichor Medical Systems Inc
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Filing: 1995-06-07
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Granted: 2000-03-21
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Expires: 2015-06-07
Abstract
Abstract A method for delivering a therapeutic agent to a predetermined location in a host is disclosed, wherein a liposome-encapsulated therapeutic agent is administered to the host, and an electrical field which encompasses a predetermined region within the host is established, such that as the liposome-encapsulated agent is exposed to the electrical field the release of the agent from the liposome to the predetermined region is enhanced.
Inventors
- 👤 Jeffrey P. Walker
- 👤 Robert M. Bernard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:01
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/327; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0412; A61N1/0472; A61N1/0476; A61N1/20; A61N1/30; A61K; A61K9/00; A61K9/0002; A61K9/0009; A61K9/10; A61K9/127; A61N1/0428; A61N1/303; A61N1/306
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
117 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically--conductive communication with at least two geometrically-oriented satellite electrodes; and electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes said control means capable of varying the number and order of electrodes that participate in each pulse delivered by said pulse generating means such that a pulse many be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously.
Claim 2
Independent Claim
117 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically--conductive communication with at least two geometrically-oriented satellite electrodes; and electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes said control means capable of varying the number and order of electrodes that participate in each pulse delivered by said pulse generating means such that a pulse many be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously.
Claim 3
Dependent Claim
31 words
A system as recited in claim 1, said control means further comprising means to control the electrical parameters and temporal relationship of the electrical pulses applied to each of said electrodes.
Claim 4
Dependent Claim
15 words
A system as recited in claim 2, wherein said control means comprises a digital computer.
Claim 5
Dependent Claim
36 words
A system as recited in claim 2, wherein said control means can apply electrical pulses of different polarity to selected electrodes so as to redefine the reference and satellite relationship as between the plurality of electrodes.
Claim 6
Dependent Claim
35 words
A system as recited in claim 1, wherein the electrical pulse generating means generates an electrical field strength in the range of approximately 0.4 kV/cm to approximately 1.3 kV/cm in the tissue of a patient.
Claim 7
Independent Claim
144 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically-conductive communication with at least two geometrically-oriented satellite electrodes; electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes capable of varying the number and order of electrodes that participate in each pulse delivered such that a pulse may be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously; and control means connecting said electrical pulse generating means to at least three of said electrodes, which control means directs the electrical parameters and temporal relationship of the electrical pulses applied to each of said electrodes.
Claim 8
Independent Claim
144 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically-conductive communication with at least two geometrically-oriented satellite electrodes; electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes capable of varying the number and order of electrodes that participate in each pulse delivered such that a pulse may be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously; and control means connecting said electrical pulse generating means to at least three of said electrodes, which control means directs the electrical parameters and temporal relationship of the electrical pulses applied to each of said electrodes.
Claim 9
Dependent Claim
15 words
A system as recited in claim 6, wherein said control means comprises a digital computer.
Claim 10
Dependent Claim
36 words
A system as recited in claim 6, wherein said control means can apply electrical pulses of different polarity lo selected electrodes so as to redefine the reference and satellite relationship as between the plurality of electrodes.
Claim 11
Dependent Claim
35 words
A system as recited in claim 6, wherein the electrical pulse generating means generates an electrical field strength in the range of approximately 0.4 kV/cm to approximately 1.3 kV/cm in the issue of a patient.
Claim 12
Independent Claim
152 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically-conductive communication with at least two geometrically-oriented satellite electrodes; electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes capable of varying the number and order of electrodes that participate in each pulse delivered such that a pulse may be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously; and control means connecting said electrical pulse generating means to at least three of said electrodes, which control means can apply electrical pulses of different polarity to selected electrodes so as to redefine the reference and satellite relationship as between the plurality of electrodes.
Claim 13
Independent Claim
152 words
A system for the delivery of electroporation-inducing electrical fields to a patient comprising: a plurality of electrodes adapted to be located within a predetermined three-dimensional space in a patient, said electrodes arranged to provide at least one reference electrode in electrically-conductive communication with at least two geometrically-oriented satellite electrodes; electrical pulse generating means for generating electroporation-inducing electrical fields incorporating control means connected to at least three of said plurality of electrodes capable of varying the number and order of electrodes that participate in each pulse delivered such that a pulse may be delivered to at least said reference electrode and at least two of said satellite electrodes simultaneously; and control means connecting said electrical pulse generating means to at least three of said electrodes, which control means can apply electrical pulses of different polarity to selected electrodes so as to redefine the reference and satellite relationship as between the plurality of electrodes.
Claim 14
Dependent Claim
15 words
A system as recited in claim 10, wherein said control means comprises a digital computer.
Claim 15
Dependent Claim
35 words
A system as recited in claim 10, wherein the electrical pulse generating means generates an electrical field strength in the range of approximately 0.4 kV/cm to approximately 1.3 kV/cm in the tissue of a patient.
References Cited (Backward Citations)
US5547467A
Cited
US5749847A
Cited
US5389069A
Cited
US5667491A
Cited
US5676646A
Cited
US5545130A
Cited
US5501662A
Cited
US5507724A
Cited
US5688233A
Cited
US5464386A
Cited
US5462520A
Cited
US5674267A
Cited
US5439440A
Cited
US5472441A
Cited
US5702359A
Cited
US5704908A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-03-21 | 2003-09-20 | 2004-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-03-21 | 2007-09-20 | 2008-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-03-21 | 2011-09-20 | 2012-03-21 | $7700.00 | Window Closed / Lapsed |