US5704908A
Expired / Lapsed
US
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Electroporation and iontophoresis catheter with porous balloon
Assignee: Genetronics Inc
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Filing: 1996-10-10
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Granted: 1998-01-06
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Expires: 2016-10-10
Abstract
Abstract An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient includes an elongated catheter having a proximal end and a distal end and a guide wire extending from the proximal end to the distal end, an inflatable balloon carried by the distal end, the balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber between the two bladders, a first electrode on an outer surface of the outer perforated bladder, a second electrode spaced from the first electrode, a remote electrode, a lumen for delivering a predetermined quantity of a fluid medium carrying preselected molecules into the chamber to be infused into the body cavity at the predetermined location; and a source of power for applying a voltage pulse between selected pairs of the electrodes for transport of the molecules by iontophoresis and/or repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter the cells.
Inventors
- 👤 Gunter A. Hofmann
- 👤 Lois J. Crandell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:24
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/327; A61N1/325; A61N1/20; A61N1/30; A61N1/303; A61N1/306
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
180 words
An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising: an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween; means defining a first electrode on an outer surface of the inflatable portion of said outer perforated bladder; means associated with said distal end defining a second electrode spaced from said first electrode; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber to be infused into said body cavity at the predetermined location; and means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells.
Claim 2
Dependent Claim
180 words
An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising: an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween; means defining a first electrode on an outer surface of the inflatable portion of said outer perforated bladder; means associated with said distal end defining a second electrode spaced from said first electrode; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber to be infused into said body cavity at the predetermined location; and means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells.
Claim 3
Dependent Claim
30 words
An apparatus according to claim 1 wherein said means defining a first electrode on an outer surface of said outer perforated bladder is a conductive coating on said outer surface.
Claim 4
Dependent Claim
31 words
An apparatus according to claim 1 wherein said means defining a first electrode on an outer surface of said outer perforated bladder comprises a conductive elastomeric material defining said outer bladder.
Claim 5
Dependent Claim
21 words
An apparatus according to claim 3 wherein said means defining a second electrode comprises an exposed portion of said guide wire.
Claim 6
Dependent Claim
21 words
An apparatus according to claim 1 wherein said means defining a second electrode comprises an exposed portion of said guide wire.
Claim 7
Dependent Claim
20 words
An apparatus according to claim 5 wherein said exposed portion of said guide wire is exterior of said inflatable balloon.
Claim 8
Dependent Claim
20 words
An apparatus according to claim 5 wherein said exposed portion of said guide wire is interior of said inflatable balloon.
Claim 9
Dependent Claim
21 words
An apparatus according to claim 1 wherein said means defining a second electrode comprises a conductive coating on said outer surface.
Claim 10
Dependent Claim
21 words
An apparatus according to claim 8 wherein said means defining a first electrode comprises a conductive coating on said outer surface.
Claim 11
Dependent Claim
30 words
An apparatus according to claim 9 wherein said conductive coating defining said first electrode and said conductive coating defining said second electrode each comprises a band around said outer surface.
Claim 12
Dependent Claim
16 words
An apparatus according to claim 1 further comprising at least a third and a fourth electrodes.
Claim 13
Dependent Claim
52 words
An apparatus according to claim 1 further comprising another inflatable balloon carried by said distal end, said another balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween, and wherein said second electrode is defined by an outer surface of said outer bladder of said another balloon.
Claim 14
Dependent Claim
88 words
An apparatus according to claim 1 wherein the means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of the voltage pulse having a wave form selected from the group consisting of an exponentially decaying pulse, a square pulse, a unipolar oscillating pulse train and a bipolar oscillating pulse train, the electric field having a strength of between approximately 0.2 kV/cm and 20.0 kV/cm, and each pulse having a duration of between approximately ten microseconds and one hundred milliseconds.
Claim 15
Dependent Claim
46 words
A catheter according to claim 1 further comprising another inflatable balloon carried by said distal end, said another balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween, and said outer bladder having a conductive outer surface defining said second electrode.
Claim 16
Dependent Claim
15 words
A catheter according to claim 1 further comprising a remote electrode external to said catheter.
Claim 17
Dependent Claim
14 words
A catheter according to claim 15 wherein said remote electrode is a penetrating electrode.
Claim 18
Dependent Claim
208 words
An electroporation catheter for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising: an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder having perforations defining a chamber therebetween; said outer perforated bladder having a conductive outer surface defining a first electrode on the inflatable portion of said perforated bladder for engagement with walls of said cavity; a second electrode spaced from said first electrode carried by Said distal end of said catheter; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber for infusing via said perforations into said cavity at the predetermined location; and conductor means at said proximal end of said catheter for connecting to a power source for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells.
Claim 19
Dependent Claim
208 words
An electroporation catheter for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising: an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder having perforations defining a chamber therebetween; said outer perforated bladder having a conductive outer surface defining a first electrode on the inflatable portion of said perforated bladder for engagement with walls of said cavity; a second electrode spaced from said first electrode carried by Said distal end of said catheter; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber for infusing via said perforations into said cavity at the predetermined location; and conductor means at said proximal end of said catheter for connecting to a power source for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells.
Claim 20
Dependent Claim
18 words
A catheter according to claim 17 wherein said conductive outer surface comprises a coating on said outer surface.
Claim 21
Dependent Claim
20 words
A catheter according to claim 18 wherein said conductive outer surface comprises a conductive elastomeric material defining said outer bladder.
Claim 22
Dependent Claim
27 words
A catheter according to claim 18 wherein said means defining a second electrode comprises a conductive coating on said outer surface spaced from said first conductive surface.
Claim 23
Dependent Claim
30 words
A catheter according to claim 20 wherein said conductive coating defining said first electrode and said conductive coating defining said second electrode each comprises a band around said outer surface.
Claim 24
Dependent Claim
24 words
A catheter according to claim 17 wherein said means defining a second electrode comprises a second conductive outer surface spaced from said first surface.
Claim 25
Dependent Claim
87 words
A catheter according to claim 17 further comprising means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields, the voltage pulse having a wave form selected from the group consisting of an exponentially decaying pulse, a square pulse, a unipolar oscillating pulse train and a bipolar oscillating pulse train, the electric field having a strength of between approximately 0.2 kV/cm and 20.0 kV/cm, and each pulse having a duration of between approximately ten microseconds and one hundred milliseconds.
Claim 26
Dependent Claim
15 words
A catheter according to claim 17 further comprising a remote electrode external to said catheter.
Claim 27
Dependent Claim
14 words
A catheter according to claim 24 wherein said remote electrode is a penetrating electrode.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-05 | 2001-07-07 | 2002-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-05 | 2005-07-07 | 2006-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-05 | 2009-07-07 | 2010-01-06 | $7700.00 | Window Closed / Lapsed |