Patent US6013591A successfully refreshed from Google Patents.
US6013591A
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Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
Assignee: Massachusetts Institute of Technology
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Filing: 1998-01-16
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Granted: 2000-01-11
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Expires: 2018-01-16
Abstract
Abstract Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
Inventors
- 👤 Jackie Y. Ying
- 👤 Edward S. Ahn
- 👤 Atsushi Nakahira
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:33
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/12; A61L27/28; A61L27/30; A61L27/32; B; B82; B82Y; B82Y30/00; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C03; C03C; C03C14/00; C03C4/00; C03C4/0007; C03C4/0021; C04; C04B; C04B35/00; C04B35/01; C04B35/10; C04B35/111; C04B35/117; C04B35/447; C04B35/46; C04B35/48; C04B35/486; C04B35/488; C04B35/622; C04B35/626; C04B35/62605; C04B35/6261; C04B35/6262; C04B35/62645; C04B35/62675; C04B35/64; C04B35/645; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00185; A61F2310/00239; A61F2310/00293; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61L2400/00; A61L2400/12; C04B2235/00; C04B2235/02; C04B2235/30; C04B2235/32; C04B2235/3205; C04B2235/3208; C04B2235/3212; C04B2235/3217; C04B2235/3224; C04B2235/3225; C04B2235/3231; C04B2235/3232; C04B2235/3244; C04B2235/3246; C04B2235/50; C04B2235/54; C04B2235/5409; C04B2235/5418; C04B2235/5445; C04B2235/5454; C04B2235/549; C04B2235/60; C04B2235/608; C04B2235/65; C04B2235/656; C04B2235/6562; C04B2235/6567; C04B2235/66; C04B2235/668; C04B2235/70; C04B2235/74; C04B2235/77; C04B2235/78; C04B2235/785; C04B2235/80; C04B2235/96; C04B2235/9646; C04B2235/9653; F; F16; F16C; F16C2240/00; F16C2240/40; F16C2240/60; F16C2240/64; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/773; Y10S977/775; Y10S977/776
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
21 words
A composition, comprising particulate apatite having an average apatite crystal size of less than 100 nm, wherein the crystal is spherical.
Claim 2
Dependent Claim
21 words
A composition, comprising particulate apatite having an average apatite crystal size of less than 100 nm, wherein the crystal is spherical.
Claim 3
Dependent Claim
19 words
The composition of claim 1 comprising particulate apatite having an average apatite crystal size of less than 50 nm.
Claim 4
Dependent Claim
19 words
The composition of claim 1 comprising particulate apatite having an average apatite crystal size of less than 30 nm.
Claim 5
Dependent Claim
19 words
The composition of claim 1 comprising particulate apatite having an average apatite crystal size of less than 20 nm.
Claim 6
Dependent Claim
12 words
A composition as in claim 1 wherein the particulate apatite is densified.
Claim 7
Dependent Claim
17 words
The composition of claim 1 comprising apatite having an average particle size of less than 1 μm.
Claim 8
Dependent Claim
17 words
The composition of claim 1 comprising apatite having an average particle size of less than 0.5 μm.
Claim 9
Dependent Claim
17 words
The composition of claim 1 comprising apatite having an average particle size of less than 0.25 μm.
Claim 10
Dependent Claim
20 words
A composition comprising particulate apatite having a surface area of at least 40 m 2 /g and a spherical crystal.
Claim 11
Dependent Claim
20 words
A composition comprising particulate apatite having a surface area of at least 40 m 2 /g and a spherical crystal.
Claim 12
Dependent Claim
19 words
The composition of claim 7 comprising particulate apatite having a surface area of at least 100 m 2 /g.
Claim 13
Dependent Claim
19 words
The composition of claim 9 comprising particulate apatite having a surface area of at least 150 m 2 /g.
Claim 14
Dependent Claim
28 words
The composition of claim 9 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1000° C. for at least 2 hours.
Claim 15
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1000° C. for at least 2 hours.
Claim 16
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1000° C. for at least 2 hours.
Claim 17
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1100° C. for at least 2 hours.
Claim 18
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1100° C. for at least 2 hours.
Claim 19
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1100° C. for at least 2 hours.
Claim 20
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1200° C. for at least 2 hours.
Claim 21
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1200° C. for at least 2 hours.
Claim 22
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1200° C. for at least 2 hours.
Claim 23
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1300° C. for at least 2 hours.
Claim 24
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1300° C. for at least 2 hours.
Claim 25
Dependent Claim
28 words
The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1300° C. for at least 2 hours.
Claim 26
Dependent Claim
18 words
An article having a dimension of at least 0.5 cm made up of the composition of claim 1.
Claim 27
Dependent Claim
11 words
The article of claim 24 wherein the particulate apatite is consolidated.
Claim 28
Dependent Claim
12 words
The article of claim 24, formed into the shape of a prosthesis.
Claim 29
Dependent Claim
9 words
The article of claim 24 that is a prosthesis.
Claim 30
Dependent Claim
12 words
The article of claim 24 comprising an exterior coating on a prosthesis.
Claim 31
Dependent Claim
19 words
The article of claim 28 comprising an exterior coating, on a prosthesis, of at least 0.5 micron in thickness.
Claim 32
Dependent Claim
13 words
The article of claim 24 having a theoretical density of at least 90%.
Claim 33
Dependent Claim
13 words
The article of claim 24 having a theoretical density of at least 95%.
Claim 34
Dependent Claim
13 words
The article of claim 24 having a theoretical density of at least 98%.
Claim 35
Dependent Claim
18 words
An article having a dimension of at least 0.5 cm made up of the composition of claim 9.
Claim 36
Dependent Claim
12 words
The article of claim 33 having a porosity of at least 20%.
Claim 37
Dependent Claim
12 words
The article of claim 33 having a porosity of at least 30%.
Claim 38
Dependent Claim
12 words
The article of claim 33 having a porosity of at least 50%.
Claim 39
Dependent Claim
12 words
The article of claim 33 having a porosity of at least 75%.
Claim 40
Dependent Claim
15 words
The densified article of claim 33 having compressive strength of at least about 150 MPa.
Claim 41
Dependent Claim
14 words
The densified article of claim 38, having a density of at least about 98%.
Claim 42
Dependent Claim
15 words
The densified article of claim 33 having compressive strength of at least about 500 MPa.
Claim 43
Dependent Claim
15 words
The densified article of claim 33 having compressive strength of at least about 700 MPa.
Claim 44
Dependent Claim
14 words
The densified article of claim 38, having a density of at least about 90%.
Claim 45
Dependent Claim
14 words
The densified article of claim 38, having a density of at least about 95%.
Claim 46
Dependent Claim
12 words
The article of claim 24 that is a part of a prosthesis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-01-10 | 2003-07-12 | 2004-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-01-10 | 2007-07-12 | 2008-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-01-10 | 2011-07-12 | 2012-01-11 | $7700.00 | Window Closed / Lapsed |