Abstract An iontophoretic drug delivery system of the present invention includes a controller interconnectable with a drug-filled patch. The controller includes electronic circuitry which monitors and controls the supply of electrical current to the drug-filled patch during delivery of at least one drug, and the electronic circuitry includes a circuit for causing a voltage step in a battery of a plurality of serially-connected cells. Specifically, the circuit causes one or more of the cells to discharge through a resistor at a higher rate than the other cells, thus producing a voltage step when the faster discharging cell dies before the other cells. A reverse-biased diode is connected in parallel to the faster discharging cell to cause the current to bypass the faster discharging cell after it has died, thus preventing it from reverse charging. This circuitry may be controlled to adjust the higher rate of discharge, and thus the time of occurrence of the voltage step.
A controller for use in combination with a patch to form an operable iontophoretic drug delivery system, said controller comprising: electronic circuitry including a circuit for causing a higher rate of discharge of at least one of a plurality of serially-connected cells forming a battery, the battery capable of supplying a current to a device, said circuit having a switch connected to a first electrode of the at least one cell; a resistor connected in series with said switch and to a second electrode of the at least one cell, the at least one cell additionally discharging through said resistor when said switch is closed; and a reversed bias diode connected between said first electrode and said second electrode of the at least one cell so that said diode is in parallel with said resistor when said switch is closed, and in parallel to the at least one cell, said reversed-biased diode causing the current to bypass the at least one cell when the at least one cell has died.
Claim 2
Dependent Claim
170 words
A controller for use in combination with a patch to form an operable iontophoretic drug delivery system, said controller comprising: electronic circuitry including a circuit for causing a higher rate of discharge of at least one of a plurality of serially-connected cells forming a battery, the battery capable of supplying a current to a device, said circuit having a switch connected to a first electrode of the at least one cell; a resistor connected in series with said switch and to a second electrode of the at least one cell, the at least one cell additionally discharging through said resistor when said switch is closed; and a reversed bias diode connected between said first electrode and said second electrode of the at least one cell so that said diode is in parallel with said resistor when said switch is closed, and in parallel to the at least one cell, said reversed-biased diode causing the current to bypass the at least one cell when the at least one cell has died.
Claim 3
Dependent Claim
17 words
A controller according to claim 1, wherein the closing of said switch is controlled by the device.
Claim 4
Dependent Claim
13 words
A controller according to claim 1, wherein said switch is an electronic switch.
Claim 5
Dependent Claim
17 words
A controller according to claim 1, wherein the battery is also connected to a voltage monitoring circuit.
Claim 6
Dependent Claim
33 words
A controller according to claim 4, wherein the voltage monitoring circuit detects a voltage step when the at least one cell has died and sends a voltage step detection signal to the device.