Histidine containing nutriceutical compositions

Claim 2

A nutriceutical composition comprising: (a) 100 to 1500 mg of a cyto-protective agent selected from the group consisting of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof; and (b) an effective amount of at least one of a phytonutrient having antioxidant activity selected from the group consisting of carotenoids, flavonoids, tocopherols, ascorbates and mixtures thereof; and (c) a pharmaceutical acceptable carrier selected from the group consisting of cellulose, methyl cellulose, carboxymethylcellulose and hydroxypropylmethylcellulose; and; (d) 0.5 to 20 mg of a lubricating agent.

Claim 3

The nutriceutical composition of claim 1 wherein said tocopherol is Vitamin E.

Claim 4

The nutriceutical composition of claim 1 wherein said carotenoid is canthanxantin.

Claim 5

The nutriceutical composition of claim 1 wherein said carotenoid is β-carotene.

Claim 6

The nutriceutical composition of claim 1 wherein said carotenoid is limonene.

Claim 7

The nutriceutical composition of claim 1 wherein said carotenoid is vitamin A.

Claim 8

The nutriceutical composition of claim 1 wherein said phytonutrient having antioxidant activity is a mixture comprising an effective amount of ascorbic acid and an effective amount of tocopherol.

Claim 9

An antioxidant dietary supplement comprising: (a) a cytoprotective effective amount of a cytoprotective agent selected from the group consisting of least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof; (b) an effective amount of ascorbic acid; (c) an effective amount of alpha-tocopherol; and (d) an effective amount of lipoic acid.

Claim 10

An antioxidant dietary supplement comprising: (a) a cytoprotective effective amount of a cytoprotective agent selected from the group consisting of least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof; (b) an effective amount of ascorbic acid; (c) an effective amount of alpha-tocopherol; and (d) an effective amount of lipoic acid.

Claim 11

The antioxidant formulation of claim 8 further including an effective amount of a pharmaceutical acceptable salt of magnesium.

Claim 12

A method of providing nutrition to a mammal in need thereof, which method comprises administering to said mammal the composition of claim 1.

Claim 13

A controlled release formulation in tablet form for once-daily oral administration of about 500-1500 mg of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof, which tablet comprises a homogeneous matrix comprising: about 3-12 weight percent of hydroxypropyl methylcellulose having a number average molecular weight in the range of from about 50,000 to about 150,000; about 75-97 weight percent of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof in an amount effective for once daily oral administration; about 0.05 to about 4 weight percent of a pharmaceutically acceptable lubricating agent; and an effective percentage amount of at least one of a phytonutrient having antioxidant activity selected from the group consisting of carotenoids, flavonoids, tocopherols, ascorbates and mixtures thereof.

Claim 14

A controlled release formulation in tablet form for once-daily oral administration of about 500-1500 mg of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof, which tablet comprises a homogeneous matrix comprising: about 3-12 weight percent of hydroxypropyl methylcellulose having a number average molecular weight in the range of from about 50,000 to about 150,000; about 75-97 weight percent of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof in an amount effective for once daily oral administration; about 0.05 to about 4 weight percent of a pharmaceutically acceptable lubricating agent; and an effective percentage amount of at least one of a phytonutrient having antioxidant activity selected from the group consisting of carotenoids, flavonoids, tocopherols, ascorbates and mixtures thereof.

Claim 15

The controlled release tablet of claim 11 which contains L-histidine.

Claim 16

The controlled release tablet of claim 12 in which the amount of L-histidine is about 500 mg, 750 mg, 1000 mg or 1500 mg.

Claim 17

The controlled release tablet of claim 12 in which the hydroxypropyl methylcellulose has a number average molecular weight of about 125,000-135,000.

Claim 18

The controlled release tablet of claim 14 in which the hydroxypropyl methylcellulose constitutes about 5-8 weight percent of the matrix.

Claim 19

The controlled release tablet of claim 15 in which the matrix comprises: about 6 weight percent of the hydroxypropyl methylcellulose; about 80-94 weight percent L-histidine, and about 0.1 to about 2 weight percent pharmaceutically acceptable lubricating agent.

Claim 20

The controlled release tablet of claim 16 wherein the amount of L-histidine is about 500 mg, 750 mg, 1000 mg or 1500 mg.

Claim 21

The controlled release tablet of claim 17 which includes a pharmaceutically acceptable coating.

Claim 22

The controlled release tablet of claim 14 in which the matrix comprises: about 8 weight percent of the hydroxypropyl methylcellulose, about 85-92 weight percent L-histidine, and 0.1 to about 2 weight percent lubricating agent.

Claim 23

The controlled release tablet of claim 19 in which the amount of L-histidine is about 500 mg, 750 mg, 1000 mg or 1500 mg.

Claim 24

The controlled release tablet of claim 20 which includes a pharmaceutically acceptable coating.

Claim 25

The controlled release tablet of claim 14 in which comprises: (a) a matrix comprising about 7 weight percent of the hydroxypropyl methylcellulose; about 89-93 weight percent L-histidine; and 0.1 to about 2 weight percent lubricating agent; and (b) pharmaceutically acceptable coating.

Claim 26

The controlled release tablet of claim 19 which comprises: (a) a matrix comprising about 8 weight percent of the hydroxypropyl methylcellulose; about 91 weight percent L-histidine; and about 1 weight percent magnesium stearate, and (b) a pharmaceutically acceptable coating.

Claim 27

The controlled release tablet of claim 23 in which the amount of L-histidine is about 500 mg, 750 mg, 1000 mg or 1500 mg.