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US5945319A
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Periodate oxidative method for attachment of biomolecules to medical device surfaces
Assignee: Medtronic Inc
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Filing: 1997-12-31
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Granted: 1999-08-31
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Expires: 2017-12-31
Abstract
Abstract Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A 2-aminoalcohol moiety of a biomolecule is oxidized with a periodate to an aldehyde moiety which is reacted with an amine moiety on the surface of a medical device to form an imine moiety, and the imine moiety is reduced to form an amine linkage immobilizing a coating of the biomolecule on the surface. In another method, a biomolecule coating containing an amine moiety and a 2-aminoalcohol moiety is immobilized on the surface of a medical device, the 2-aminoalcohol moiety is oxidized with a periodate to an aldehyde moiety which is reacted with the amine moiety to form an imine moiety, and the imine moiety is reduced to form a secondary amine and crosslink the coating. Each biomolecule may contain an amine moiety and a 2-aminoalcohol moiety, and the aldehyde moiety of one biomolecule resulting from periodate oxidation may react with the amine moiety of another biomolecule. In a further embodiment, a 2-aminoalcohol moiety on the surface of a medical device is oxidized with a periodate to an aldehyde moiety, and an amine moiety of a biomolecule is reacted with the aldehyde moiety to form an imine moiety which is reduced to form an amine linkage immobilizing the biomolecule on the surface.
Inventors
- 👤 James R. Keogh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:30
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/12; A61L33/128; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/28; A61L27/34; A61L29/00; A61L29/08; A61L29/085; A61L31/00; A61L31/08; A61L31/10; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/0047; A61L33/0076; A61L33/0082; A61L33/18; C; C08; C08L; C08L89/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 79
Claim 1
Independent Claim
127 words
A method of crosslinking a coating on a surface of a medical device, the coating imparting improved biocompatibility characteristics to the surface, the surface being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) immobilizing a biomolecule on the surface, the biomolecule forming a coating comprising an amine moiety and a 2-aminoalcohol moiety; (b) applying a periodate to the coating to oxidize the 2-aminoalcohol moiety to form an aldehyde moiety; (c) allowing the aldehyde moiety to combine with the amine moiety to form an imine moiety; and (d) reacting the imine moiety with a reducing agent to form a secondary amine and thereby cause at least portions of the coating to crosslink.
Claim 2
Independent Claim
127 words
A method of crosslinking a coating on a surface of a medical device, the coating imparting improved biocompatibility characteristics to the surface, the surface being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) immobilizing a biomolecule on the surface, the biomolecule forming a coating comprising an amine moiety and a 2-aminoalcohol moiety; (b) applying a periodate to the coating to oxidize the 2-aminoalcohol moiety to form an aldehyde moiety; (c) allowing the aldehyde moiety to combine with the amine moiety to form an imine moiety; and (d) reacting the imine moiety with a reducing agent to form a secondary amine and thereby cause at least portions of the coating to crosslink.
Claim 3
Dependent Claim
71 words
The method of claim 1, wherein the device is selected from the group consisting of a blood-contacting medical device, a tissue-contacting medical device, a bodily fluid-contacting medical device, an implantable medical device, an extracorporeal medical device, a blood oxygenator, a blood pump, tubing for carrying blood, an endoprosthesis medical device, a vascular graft, a stent, a pacemaker lead, a heart valve, temporary intravascular medical device, a catheter and a guide wire.
Claim 4
Dependent Claim
85 words
The method of claim 1, wherein the biomolecule is selected from the group consisting of an antithrombotic, a clotting agent, an anti-inflammatory, an antibody, an immunoglobulin, an enzyme, a hormone, a neurotransmitter, a cytokine, a globular protein, a regulatory agent, a cell attachment protein, a cell attachment peptide, a proteoglycan, a toxin, an antibiotic, an antibacterial agent, an antimicrobial agent, a catalyst, a drug, a vitamin, an antibody, an antigen, a protein, a peptide, a DNA segment, a RNA segment, a dye and a ligand.
Claim 5
Dependent Claim
13 words
The method of claim 1, wherein the biomolecule is a naturally occurring biomolecule.
Claim 6
Dependent Claim
13 words
The method of claim 1, wherein the biomolecule is a chemically synthesized biomolecule.
Claim 7
Dependent Claim
13 words
The method of claim 1, wherein the biomolecule comprises an amino acid residue.
Claim 8
Dependent Claim
26 words
The method of claim 6, wherein the amino acid residue is selected from the group consisting of a N-terminal serine, a N-terminal threonine and a 5-hydroxylysine.
Claim 9
Dependent Claim
14 words
The method of claim 6, wherein the amino acid residue is a lysine residue.
Claim 10
Dependent Claim
20 words
The method of claim 6, wherein the biomolecule is selected from the group consisting of a peptide and a protein.
Claim 11
Dependent Claim
41 words
The method of claim 9, wherein the peptide is selected from the group consisting of an an antithrombotic peptide, an anti-inflammatory peptide, an enzyme, a hormone, a neurotransmitter, a cytokine, a cell attachment peptide, a toxin, an antibiotic, and a ligand.
Claim 12
Dependent Claim
13 words
The method of claim 9, wherein the peptide is a naturally occurring peptide.
Claim 13
Dependent Claim
13 words
The method of claim 9, wherein the peptide is a chemically synthesized peptide.
Claim 14
Dependent Claim
43 words
The method of claim 9, wherein the protein is selected from the group consisting of an antithrombotic protein, an anti-inflammatory protein, an antibody, an immunoglobulin, an enzyme, a hormone, a globular protein, a cell attachment protein, a proteoglycan, a toxin, and a ligand.
Claim 15
Dependent Claim
13 words
The method of claim 9, wherein the protein is a naturally occurring protein.
Claim 16
Dependent Claim
13 words
The method of claim 9, wherein the protein is a chemically synthesized protein.
Claim 17
Dependent Claim
23 words
The method of claim 1, wherein the periodate comprises at least one of periodic acid, sodium periodate, alkali metal periodates, and potassium periodate.
Claim 18
Dependent Claim
30 words
The method of claim 1, wherein the periodate is combined with 2-aminoalcohol moiety and the amine moiety in an aqueous solution having a pH between about 4 and about 9.
Claim 19
Dependent Claim
33 words
The method of claim 1, wherein the periodate is combined with the 2-aminoalcohol moiety and the amine moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 20
Dependent Claim
16 words
The method of claim 1, wherein the oxidizing step is performed in the absence of light.
Claim 21
Dependent Claim
21 words
The method of claim 1, wherein the reducing agent comprises at least one of sodium borohydride, sodium cyanoborohydride, and amine borane.
Claim 22
Dependent Claim
31 words
The method of claim 1, wherein the reducing agent is combined with the material comprising an imine moiety in an aqueous solution having a pH between about 6 and about 10.
Claim 23
Dependent Claim
30 words
The method of claim 1, wherein the reducing agent is combined with the imine moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 24
Dependent Claim
31 words
The method of claim 1, wherein at least a portion of the surface forms at least one of a tube, a rod, a membrane, a balloon, a bag and a sheet.
Claim 25
Dependent Claim
93 words
The method of claim 1, wherein the medical device comprises at least one of a biocompatible material selected from the group consisting of metal, titanium, titanium alloys, tin-nickel alloys, shape memory alloys, aluminum oxide, platinum, platinum alloys, stainless steel, MP35N stainless steel, elgiloy, stellite, pyrolytic carbon, silver carbon, glassy carbon, polymer, polyamide, polycarbonate, polyether, polyester, polyolefin, polyethylene, polypropylene, polystyrene, polyurethane, polyvinyl chloride, polyvinylpyrrolidone, silicone elastomer, fluoropolymer, polyacrylate, polyisoprene, polytetrafluoroethylene, rubber, ceramic, hydroxapatite, human protein, human tissue, animal protein, animal tissue, bone, skin, teeth, collagen, laminin, elastin, fibrin, wood, cellulose, compressed carbon and glass.
Claim 26
Independent Claim
113 words
A method of forming a crosslinked biomaterial for use in a medical device, the biomaterial being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) combining a periodate with two or more biomolecules, the biomolecules comprising an amine moiety and a 2-aminoalcohol moiety, the periodate to oxidize the 2-aminoalcohol moiety to form an aldehyde moiety; (b) allowing the aldehyde moiety of one biomolecule to combine with the amine moiety of another biomolecule to form an imine moiety; and (c) reacting the imine moiety with a reducing agent to form a secondary amine and thereby forming a crosslinked biomaterial.
Claim 27
Independent Claim
113 words
A method of forming a crosslinked biomaterial for use in a medical device, the biomaterial being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) combining a periodate with two or more biomolecules, the biomolecules comprising an amine moiety and a 2-aminoalcohol moiety, the periodate to oxidize the 2-aminoalcohol moiety to form an aldehyde moiety; (b) allowing the aldehyde moiety of one biomolecule to combine with the amine moiety of another biomolecule to form an imine moiety; and (c) reacting the imine moiety with a reducing agent to form a secondary amine and thereby forming a crosslinked biomaterial.
Claim 28
Dependent Claim
86 words
The method of claim 25, wherein the medical device is selected from the group consisting of a blood-contacting medical device, a tissue-contacting medical device, a bodily fluid-contacting medical device, an implantable medical device, an extracorporeal medical device, a blood oxygenator, a blood pump, tubing for carrying blood, an endoprosthesis medical device, a cell seeding medical device, a cell binding medical device, a cell separating medical device, a vascular graft, a stent, a heart valve, a collagen glue, a tissue adhesive, and a temporary intravascular medical device.
Claim 29
Dependent Claim
32 words
The method of claim 25, wherein at least a portion of the crosslinked biomaterial forms at least one of a tube, a rod, a membrane, a balloon, a bag and a sheet.
Claim 30
Dependent Claim
89 words
The method of claim 25, wherein at least one of the at least two biomolecules is selected from the group consisting of an antithrombotic, a clotting agent, an antiinflammatory, an antibody, an immunoglobulin, an enzyme, a hormone, a neurotransmitter, a cytokine, a globular protein, a cell attachment protein, a cell attachment peptide, a proteoglycan, a toxin, an antibiotic, an antibacterial agent, an antimicrobial agent, a catalyst, a drug, a vitamin, an antibody, an antigen, a protein, a peptide, a DNA segment, a RNA segment, a dye and a ligand.
Claim 31
Dependent Claim
20 words
The method of claim 25, wherein at least one of the at least two biomolecules is a naturally occurring biomolecule.
Claim 32
Dependent Claim
20 words
The method of claim 25, wherein at least one of the at least two biomolecules is a chemically synthesized biomolecule.
Claim 33
Dependent Claim
20 words
The method of claim 25, wherein at least one of the at least two biomolecules comprises an amino acid residue.
Claim 34
Dependent Claim
14 words
The method of claim 31, wherein the amino acid residue comprises a 2-aminoalcohol moiety.
Claim 35
Dependent Claim
26 words
The method of claim 32, wherein the amino acid residue is selected from the group consisting of a N-terminal serine, a N-terminal threonine and a 5-hydroxylysine.
Claim 36
Dependent Claim
14 words
The method of claim 31, wherein the amino acid residue comprises an amine moiety.
Claim 37
Dependent Claim
14 words
The method of claim 34, wherein the amino acid residue is a lysine residue.
Claim 38
Dependent Claim
27 words
The method of claim 31, wherein at least one of the at least two biomolecules is selected from the group consisting of a peptide and a protein.
Claim 39
Dependent Claim
40 words
The method of claim 36, wherein the peptide is selected from the group consisting of an antithrombotic peptide, an anti-inflammatory peptide, an enzyme, a hormone, a neurotransmitter, a cytokine, a cell attachment peptide, a toxin, an antibiotic, and a ligand.
Claim 40
Dependent Claim
13 words
The method of claim 36, wherein the peptide is a naturally occurring peptide.
Claim 41
Dependent Claim
13 words
The method of claim 36, wherein the peptide is a chemically synthesized peptide.
Claim 42
Dependent Claim
43 words
The method of claim 36, wherein the protein is selected from the group consisting of an antithrombotic protein, an anti-inflammatory protein, an antibody, an immunoglobulin, an enzyme, a hormone, a globular protein, a cell attachment protein, a proteoglycan, a toxin, and a ligand.
Claim 43
Dependent Claim
13 words
The method of claim 36, wherein the protein is a naturally occurring protein.
Claim 44
Dependent Claim
13 words
The method of claim 36, wherein the protein is a chemically synthesized protein.
Claim 45
Dependent Claim
23 words
The method of claim 25, wherein the periodate comprises at least one of periodic acid, sodium periodate, alkali metal periodates, and potassium periodate.
Claim 46
Dependent Claim
30 words
The method of claim 25, wherein the periodate is combined with 2-aminoalcohol moiety and the amine moiety in an aqueous solution having a pH between about 4 and about 9.
Claim 47
Dependent Claim
33 words
The method of claim 25, wherein the periodate is combined with the 2-aminoalcohol moiety and the amine moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 48
Dependent Claim
16 words
The method of claim 25, wherein the oxidizing step is performed in the absence of light.
Claim 49
Dependent Claim
21 words
The method of claim 25, wherein the reducing agent comprises at least one of sodium borohydride, sodium cyanoborohydride, and amine borane.
Claim 50
Dependent Claim
31 words
The method of claim 25, wherein the reducing agent is combined with the material comprising an imine moiety in an aqueous solution having a pH between about 6 and about 10.
Claim 51
Dependent Claim
30 words
The method of claim 25, wherein the reducing agent is combined with the imine moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 52
Dependent Claim
27 words
The method of claim 25, further comprising the step of combining the crosslinked biomaterial with a biomolecule, the biomolecule imparting improved biocompatibility characteristics to the crosslinked biomaterial.
Claim 53
Dependent Claim
54 words
The method of claim 50, wherein the biomolecule is selected from the group consisting of an antithrombotic, a clotting agent, an anti-inflammatory, an antibody, an immunoglobulin, an enzyme, a hormone, a neurotransmitter, a cytokine, a globular protein, a cell attachment protein, a cell attachment peptide, a proteoglycan, a toxin, an antibiotic, and a ligand.
Claim 54
Dependent Claim
49 words
The method of claim 25, wherein the crosslinked biomaterial is employed as a coating on a surface of a medical device, the coating imparting improved biocompatibility characteristics to the surface, the surface being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject.
Claim 55
Dependent Claim
71 words
The method of claim 52, wherein the device is selected from the group consisting of a blood-contacting medical device, a tissue-contacting medical device, a bodily fluid-contacting medical device, an implantable medical device, an extracorporeal medical device, a blood oxygenator, a blood pump, tubing for carrying blood, an endoprosthesis medical device, a vascular graft, a stent, a pacemaker lead, a heart valve, temporary intravascular medical device, a catheter and a guide wire.
Claim 56
Dependent Claim
31 words
The method of claim 52, wherein at least a portion of the surface forms at least one of a tube, a rod, a membrane, a balloon, a bag and a sheet.
Claim 57
Dependent Claim
93 words
The method of claim 52, wherein the medical device comprises at least one of a biocompatible material selected from the group consisting of metal, titanium, titanium alloys, tin-nickel alloys, shape memory alloys, aluminum oxide, platinum, platinum alloys, stainless steel, MP35N stainless steel, elgiloy, stellite, pyrolytic carbon, silver carbon, glassy carbon, polymer, polyamide, polycarbonate, polyether, polyester, polyolefin, polyethylene, polypropylene, polystyrene, polyurethane, polyvinyl chloride, polyvinylpyrrolidone, silicone elastomer, fluoropolymer, polyacrylate, polyisoprene, polytetrafluoroethylene, rubber, ceramic, hydroxapatite, human protein, human tissue, animal protein, animal tissue, bone, skin, teeth, collagen, laminin, elastin, fibrin, wood, cellulose, compressed carbon and glass.
Claim 58
Dependent Claim
26 words
The method of claim 52, comprising the further step of combining the coating with a biomolecule, the biomolecule imparting improved biocompatibility characteristics to the crosslinked biomaterial.
Claim 59
Dependent Claim
54 words
The method of claim 56, wherein the biomolecule is selected from the group consisting of an antithrombotic, a clotting agent, an anti-inflammatory, an antibody, an immunoglobulin, an enzyme, a hormone, a neurotransmitter, a cytokine, a globular protein, a cell attachment protein, a cell attachment peptide, a proteoglycan, a toxin, an antibiotic, and a ligand.
Claim 60
Independent Claim
148 words
A method of forming a coating on a surface of a medical device, the coating imparting improved biocompatibility characteristics to the surface, the surface being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) combining a periodate with a medical device, the device having a suitable biomaterial forming the surface, a 2-aminoalcohol moiety being disposed on the surface, the periodate oxidizing the 2-aminoalcohol moiety to form an aldehyde-functional material; (b) providing a biomolecule, the biomolecule comprising an amine moiety; (c) combining the aldehyde-functional material with the amine moiety to bond the aldehyde-functional material to the amine moiety and thereby form an imine moiety; and (d) reacting the imine moiety with a reducing agent to form an amine linkage, the amine linkage immobilizing the biomolecule on the surface, the immobilized biomolecule forming the coating.
Claim 61
Independent Claim
148 words
A method of forming a coating on a surface of a medical device, the coating imparting improved biocompatibility characteristics to the surface, the surface being suitable for contacting tissue and bodily fluids in or temporarily removed from a living mammalian subject, the method comprising the ordered steps of: (a) combining a periodate with a medical device, the device having a suitable biomaterial forming the surface, a 2-aminoalcohol moiety being disposed on the surface, the periodate oxidizing the 2-aminoalcohol moiety to form an aldehyde-functional material; (b) providing a biomolecule, the biomolecule comprising an amine moiety; (c) combining the aldehyde-functional material with the amine moiety to bond the aldehyde-functional material to the amine moiety and thereby form an imine moiety; and (d) reacting the imine moiety with a reducing agent to form an amine linkage, the amine linkage immobilizing the biomolecule on the surface, the immobilized biomolecule forming the coating.
Claim 62
Dependent Claim
71 words
The method of claim 58, wherein the device is selected from the group consisting of a blood-contacting medical device, a tissue-contacting medical device, a bodily fluid-contacting medical device, an implantable medical device, an extracorporeal medical device, a blood oxygenator, a blood pump, tubing for carrying blood, an endoprosthesis medical device, a vascular graft, a stent, a pacemaker lead, a heart valve, temporary intravascular medical device, a catheter and a guide wire.
Claim 63
Dependent Claim
82 words
The method of claim 58, wherein the biomolecule is selected from the group consisting of an antithrombotic, a clotting agent, an anti-inflammatory, an antibody, an immunoglobulin, an enzyme, a hormone, a neurotransmitter, a cytokine, a globular protein, a cell attachment protein, a cell attachment peptide, a proteoglycan, a toxin, an antibiotic, an antibacterial agent, an antimicrobial agent, a catalyst, a drug, a vitamin, an antibody, an antigen, a protein, a peptide, a DNA segment, a RNA segment, a dye and a ligand.
Claim 64
Dependent Claim
13 words
The method of claim 58, wherein the biomolecule is a naturally occurring biomolecule.
Claim 65
Dependent Claim
13 words
The method of claim 58, wherein the biomolecule is a chemically synthesized biomolecule.
Claim 66
Dependent Claim
13 words
The method of claim 58, wherein the biomolecule comprises an amino acid residue.
Claim 67
Dependent Claim
14 words
The method of claim 63, wherein the amino acid residue comprises an amine moiety.
Claim 68
Dependent Claim
13 words
The method of claim 64, wherein the amino acid residue is lysine residue.
Claim 69
Dependent Claim
23 words
The method of claim 58, wherein the periodate comprises at least one of periodic acid, sodium periodate, alkali metal periodates, and potassium periodate.
Claim 70
Dependent Claim
27 words
The met of claim 58, wherein the periodate is combined with the 2-aminoalcohol moiety in an aqueous solution having a pH between about 4 and about 9.
Claim 71
Dependent Claim
29 words
The method of claim 58, wherein the periodate is combined with the 2-aminoalcohol moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 72
Dependent Claim
16 words
The method of claim 58, wherein the oxidizing step is performed in the absence of light.
Claim 73
Dependent Claim
28 words
The method of claim 58, wherein the aldehyde-functional material and the amine-functional biomolecule are combined in an aqueous solution having a pH between about 6 and about 10.
Claim 74
Dependent Claim
30 words
The method of claim 58, wherein the aldehyde-functional material and the amine-functional biomolecule are combined in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 75
Dependent Claim
21 words
The method of claim 58, wherein the reducing agent comprises at least one of sodium borohydride, sodium cyanoborohydride, and amine borane.
Claim 76
Dependent Claim
28 words
The method of claim 58, wherein the reducing agent is combined with the imine moiety in an aqueous solution having a pH between about 6 and about 10.
Claim 77
Dependent Claim
30 words
The method of claim 58, wherein the reducing agent is combined with the imine moiety in an aqueous solution having a temperature between about 0 and about 50 degrees Celsius.
Claim 78
Dependent Claim
31 words
The method of claim 58, wherein at least a portion of the surface forms at least one of a tube, a rod, a membrane, a balloon, a bag and a sheet.
Claim 79
Dependent Claim
93 words
The method of claim 58, wherein the medical device comprises at least one of a biocompatible material selected from the group consisting of metal, titanium, titanium alloys, tin-nickel alloys, shape memory alloys, aluminum oxide, platinum, platinum alloys, stainless steel, MP35N stainless steel, elgiloy, stellite, pyrolytic carbon, silver carbon, glassy carbon, polymer, polyamide, polycarbonate, polyether, polyester, polyolefin, polyethylene, polypropylene, polystyrene, polyurethane, polyvinyl chloride, polyvinylpyrrolidone, silicone elastomer, fluoropolymer, polyacrylate, polyisoprene, polytetrafluoroethylene, rubber, ceramic, hydroxapatite, human protein, human tissue, animal protein, animal tissue, bone, skin, teeth, collagen, laminin, elastin, fibrin, wood, cellulose, compressed carbon and glass.
References Cited (Backward Citations)
US3826678A
Cited
US4613665A
Cited
US4521564A
Cited
US4600652A
Cited
US4642242A
Cited
US4786556A
Cited
US4720512A
Cited
US5053048A
Cited
US5032666A
Cited
US5077372A
Cited
US5362852A
Cited
US5344455A
Cited
US5728420A
Cited
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