US5914124A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alginate fibre, process for the preparation thereof and use
Assignee: Convatec Technologies Inc
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Filing: 1995-07-14
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Granted: 1999-06-22
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Expires: 2015-07-14
Abstract
Abstract Alginate fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament.
Inventors
- 👤 Peter M. J. Mahoney
- 👤 David Pritchard
- 👤 Anne Elizabeth Howells
- 👤 Bryan Griffiths
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:35
CPC Classifications
D; D01; D01F; D01F9/00; D01F9/04; A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L15/38; A61L15/42; A61L15/44; A61L15/46; A61P; A61P17/00; A61P17/02; Y; Y10; Y10S; Y10S424/00; Y10S424/13
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
74 words
Alginate fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 2
Dependent Claim
74 words
Alginate fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 3
Dependent Claim
33 words
Alginate fibres as claimed in claim 1 wherein the medicament is present at a level of at least 30% by weight, based on the weight of the alginate fibres with no incorporated medicament.
Claim 4
Dependent Claim
39 words
Alginate fibres as claimed in claim 1 wherein the medicament is selected from the group consisting of: antibacterial agents; gluconate or hydrochloride salts; nisin; sulphonamide derivatives; antiprotozoal agents; antifungal agents; phenothiazine derivatives; nucleosides; hormones; proteases; antibiotics; and anti-inflammatory agents.
Claim 5
Dependent Claim
39 words
Alginate fibres as claimed in claim 1 wherein the fibres are characterised by having two maxima in a plot of the first order derivative of percentage weight loss with temperature against temperature in the range 200 to 300° C.
Claim 6
Dependent Claim
111 words
Alginate fibres as claimed in claim 1 wherein the fibres are made by a process comprising the following steps: (1) treating alginate fibres with a suitable acid so as to produce fibres comprising approximately 90-98%, alginic acid fibres; (2) treating the alginic acid fibres with a saturated aqueous solution of mono- or divalent cations; (3) washing the fibres with water until imbibition of water by the fibres has effectively ceased; (4) treating the fibres with a source of a cation capable of forming a water-soluble alginate salt; and (5) contacting the fibres with one or more medicaments so as to affect uptake of the medicament into the structure of the fibre.
Claim 7
Dependent Claim
17 words
Alginate fibres as claimed in claim 5 wherein the alginate fibres in step (1) are calcium alginate.
Claim 8
Dependent Claim
17 words
Alginate fibres as claimed in claim 6 wherein other ions are included after or during step (4).
Claim 9
Dependent Claim
19 words
Alginate fibres as claimed in claim 5 wherein the fibres comprise hyaluronic acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
23 words
Alginate fibres as claimed in claim 1 wherein the fibres are characterised by having a glass transition range of less than 30° C.
Claim 11
Dependent Claim
25 words
Alginate fibres as claimed in claim 1 wherein the fibres are characterised by having a Tanδ value in the range from 0 to 15 Hz.
Claim 12
Dependent Claim
25 words
Alginate fibres as claimed in claim 1 wherein the fibres have an absorbency of at least 40.0 grams of deionized water per gram of fibres.
Claim 13
Dependent Claim
24 words
Alginate fibres as claimed in claim 1 wherein the fibres have an absorbency of at least 60 times their own weight of deionized water.
Claim 14
Independent Claim
94 words
A method of treating a wound comprising the steps of applying a wound dressing comprising alginate fibre to a wound environment, the fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre without incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 15
Independent Claim
94 words
A method of treating a wound comprising the steps of applying a wound dressing comprising alginate fibre to a wound environment, the fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre without incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 16
Dependent Claim
23 words
A method of treating a wound as claimed in claim 13 wherein the fibres in the dressing are applied in a wet state.
Claim 17
Dependent Claim
24 words
A method as claimed in claim 13 wherein the dressing is applied to the wound for a period selected from one to sixteen days.
Claim 18
Dependent Claim
86 words
An alginate fabric formed in whole or in part from alginate fibres, said fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 19
Dependent Claim
86 words
An alginate fabric formed in whole or in part from alginate fibres, said fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 20
Dependent Claim
84 words
A wound dressing formed in whole or in part from alginate fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 21
Dependent Claim
84 words
A wound dressing formed in whole or in part from alginate fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 22
Dependent Claim
23 words
A wound dressing as claimed in claim 17 comprising one or more further absorbent layers arranged on either side of the alginate fibres.
Claim 23
Dependent Claim
79 words
An implantation composition comprising an alginate fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
Claim 24
Dependent Claim
79 words
An implantation composition comprising an alginate fibre comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament, and wherein the fibres are characterized by having two maxima in a plot of the first order derivative of percentage weight loss of the fibre with temperature against temperature in the range of 100 to 400° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-06-21 | 2002-12-21 | 2003-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-06-21 | 2006-12-21 | 2007-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-06-21 | 2010-12-21 | 2011-06-22 | $7700.00 | Window Closed / Lapsed |