US5690955A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release alginate fibre and process for the preparation thereof
Assignee: CALGON VESTAL LABORATORIES Ltd
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Filing: 1993-06-28
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Granted: 1997-11-25
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Expires: 2013-06-28
Abstract
Abstract An alginate fibre is provided which includes one or more medicaments incorporated into the fibre core such that the one or more medicaments can be released in a sustained manner over time and, optionally, one or more medicaments attached to the surface of the fibre whereby the one or more medicaments attached to the surface of the fibre can be released rapidly therefrom.
Inventors
- 👤 Bryan Griffiths
- 👤 Pter Michael John Mahoney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 17:31
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/46; A61K; A61K9/00; A61K9/70; A61L15/22; A61L15/28; A61L15/44; D; D01; D01F; D01F1/00; D01F1/02; D01F1/10; D01F1/103; D01F9/00; D01F9/04; D06; D06M; D06M16/00; A61F; A61F13/00; A61F13/02; A61F13/0276; A61F2013/0296
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
92 words
An alginate fibre comprising one or more medicaments incorporated into the fibre core, and one or more medicaments attached to the surface of the fibre, wherein the concentration of medicament attached to the surface of the fibre is 0.01% to 2.0% w/w, whereby the one or more medicaments attached to the surface of the fibre can be released therefrom over a period of minutes or hours, and the one or more medicaments incorporated into the fibre core can be released in a sustained manner over a period of hours, days or weeks.
Claim 2
Dependent Claim
92 words
An alginate fibre comprising one or more medicaments incorporated into the fibre core, and one or more medicaments attached to the surface of the fibre, wherein the concentration of medicament attached to the surface of the fibre is 0.01% to 2.0% w/w, whereby the one or more medicaments attached to the surface of the fibre can be released therefrom over a period of minutes or hours, and the one or more medicaments incorporated into the fibre core can be released in a sustained manner over a period of hours, days or weeks.
Claim 3
Dependent Claim
26 words
An alginate fibre as claimed in claim 1, wherein the concentration of the medicament attached to the surface of the fibre is 0.5 to 1.5% w/w.
Claim 4
Dependent Claim
32 words
An alginate fibre as claimed in claim 1 or 2, wherein the one or more medicaments is selected from antibacterial agents, antiprotozoal agents, antifungal agents, promethazine, chlorpromazine, nucleosides, hormones and anti-inflammatory agents.
Claim 5
Dependent Claim
23 words
An alginate fibre as claimed in claim 3 wherein the one or more medicaments is selected from chlorhexidine, chlortetracycline, promethazine, noradrenalin and prednislolone.
Claim 6
Dependent Claim
24 words
An alginate fibre as claimed in any one of claims 1, 2 or 4 wherein a single medicament is incorporated into the fibre core.
Claim 7
Dependent Claim
20 words
An alginate fibre as claimed in claim 5 wherein a single medicament is attached to the surface of the fibre.
Claim 8
Dependent Claim
17 words
An alginate fibre as claimed in claim 6 wherein the medicament is chlorhexidine or a salt thereof.
Claim 9
Dependent Claim
14 words
An alginate fibre as claimed in claim 7 wherein the medicament is chlorhexidine acetate.
Claim 10
Dependent Claim
37 words
An alginate fibre as claimed in claim 1 wherein a single medicament is incorporated into the fibre core and a single medicament is attached to the surface of the fibre, the medicament at each location being identical.
Claim 11
Dependent Claim
14 words
An alginate fibre as claimed in claim 9 wherein the medicament is chlorhexidine acetate.
Claim 12
Dependent Claim
22 words
An alginate fibre as claimed in claim 1 wherein the concentration of medicament within the fibre core is 0.01% to 2.0% w/w.
Claim 13
Dependent Claim
67 words
A process for the preparation of an alginate fibre as claimed in claim 1, which process comprises the following steps: (1) spinning a solution of an alginate together with one or more medicaments; and (2) modifying the resulting fibre by attachment of one or more medicaments to the surface thereof, whereby the concentration of medicament attached to the surface of the fibre is 0.01% to 2.0% w/w.
Claim 14
Dependent Claim
29 words
A process as claimed in claim 12 wherein step (1) comprises extruding an aqueous solution of sodium alginate and one or more medicaments into a solution containing calcium ions.
Claim 15
Dependent Claim
30 words
A process as claimed in claim 12 or claim 13 wherein step (2) comprises immersion of the fibre produced in step (1) in a solution of one or more medicaments.
Claim 16
Dependent Claim
29 words
A process as claimed in claim 12 or claim 13 wherein step (2) comprises spraying a solution of one or more medicaments onto the fibre produced in step (1).
Claim 17
Dependent Claim
12 words
An alginate fibre obtained by a process as claimed in claim 12.
Claim 18
Dependent Claim
27 words
An alginate fabric formed in whole or in part from alginate fibre as claimed in any one of claims 1, 2, 4, 9, 10, 11 or 16.
Claim 19
Dependent Claim
12 words
A wound dressing comprising an alginate fabric as claimed in claim 17.
Claim 20
Dependent Claim
23 words
A method of treating a wound which method comprises the application to a wound of a wound dressing as claimed in claim 18.
References Cited (Backward Citations)
EP0279118A2
Cited
WO1989001790A1
Cited
EP0439339A2
Cited
WO1991011206A1
Cited
WO1991019470A1
Cited
WO1992022285A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-24 | 2001-05-26 | 2001-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-24 | 2005-05-26 | 2005-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-24 | 2009-05-26 | 2009-11-25 | $7700.00 | Window Closed / Lapsed |