US5891192A
Expired / Lapsed
US
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Ion-implanted protein-coated intralumenal implants
Assignee: University of California
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Filing: 1997-05-22
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Granted: 1999-04-06
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Expires: 2017-05-22
Abstract
Abstract Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative to untreated coils thus making them particularly useful in treating wide-necked brain aneurysms.
Inventors
- 👤 Yuichi Murayama
- 👤 Fernando Vinuela
- 👤 Yoshiaki Suzuki
- 👤 Masaya Iwaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 04:08
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/12; A61L33/128; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12131; A61B17/1214; A61B17/1215; A61B17/12181; A61L27/00; A61L27/28; A61L27/34; A61L31/00; A61L31/08; A61L31/10; A61L33/122; A61L33/126
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
18 words
An intralumenal implant comprising a body of a biocompatible material and an ion-implanted protein coating on the body.
Claim 2
Dependent Claim
18 words
An intralumenal implant comprising a body of a biocompatible material and an ion-implanted protein coating on the body.
Claim 3
Dependent Claim
31 words
The implant of claim 1 wherein the biocompatible material is selected from the group consisting of a metal, a bioabsorbable polymer, a bioabsorbable copolymer, a nonbioabsorbable polymer, and a nonbioabsorbable copolymer.
Claim 4
Dependent Claim
21 words
The implant of claim 2 wherein the implant is selected from the group consisting of an occlusion coil and a stent.
Claim 5
Dependent Claim
18 words
An occlusion coil comprising a coil of a biocompatible material and an ion-implanted protein coating on the coil.
Claim 6
Dependent Claim
18 words
An occlusion coil comprising a coil of a biocompatible material and an ion-implanted protein coating on the coil.
Claim 7
Dependent Claim
31 words
The coil of claim 4 wherein the biocompatible material is selected from the group consisting of a metal, a bioabsorbable polymer, a bioabsorbable copolymer, a nonbioabsorbable polymer, and a nonbioabsorbable copolymer.
Claim 8
Dependent Claim
13 words
The coil of claim 4 wherein the protein is a cell adhesion protein.
Claim 9
Dependent Claim
30 words
The coil of claim 6 wherein the biocompatible material is a metal and the cell adhesion protein is selected from the group consisting of collagen, fibronectin, vitronectin, laminin, and fibrinogen.
Claim 10
Dependent Claim
51 words
The coil of claim 4 wherein the ion is selected from the group consisting of He + , C + , N + , Ne + , Na + , K + , N 2 + , O 2 + , Kr + , H + , and Ar + .
Claim 11
Dependent Claim
51 words
The coil of claim 6 wherein the ion is selected from the group consisting of He + , C + , N + , Ne + , Na + , K + , N 2 + , O 2 + , Kr + , H + , and Ar + .
Claim 12
Dependent Claim
12 words
The coil of claim 7 wherein the ion is Ne + .
Claim 13
Independent Claim
23 words
A method for occluding a site within a mammalian body lumen comprising placing one or more ion-implanted protein-coated occlusion coils at said site.
Claim 14
Independent Claim
23 words
A method for occluding a site within a mammalian body lumen comprising placing one or more ion-implanted protein-coated occlusion coils at said site.
Claim 15
Dependent Claim
13 words
The method of claim 11 wherein the protein is a cell adhesion protein.
Claim 16
Dependent Claim
21 words
The method of claim 12 wherein the protein is selected from the group consisting of collagen, fibronectin, vitronectin, laminin, and fibrinogen.
Claim 17
Dependent Claim
51 words
The method of claim 11 wherein the ion is selected from the group consisting of He + , C + , N + , Ne + , Na + , K + , N 2 + , O 2 + , Kr + , H + , and Ar + .
Claim 18
Dependent Claim
51 words
The method of claim 12 wherein the ion is selected from the group consisting of He + , C + , N + , Ne + , Na + , K + , N 2 + , O 2 + , Kr + , H + , and Ar + .
Claim 19
Dependent Claim
12 words
The method of claim 13 wherein the ion is Ne + .
Claim 20
Dependent Claim
20 words
The method of claim 11 wherein the mammal is a human and the body lumen is a wide-necked brain aneurysm.
Claim 21
Independent Claim
42 words
A method for making an ion-implanted protein-coated intralumenal implant comprising: a) providing an implant body of a biocompatible material; b) coating the body with a protein to form a protein-coated implant body; and c) subjecting the protein-coated implant body to ion implantation.
Claim 22
Independent Claim
42 words
A method for making an ion-implanted protein-coated intralumenal implant comprising: a) providing an implant body of a biocompatible material; b) coating the body with a protein to form a protein-coated implant body; and c) subjecting the protein-coated implant body to ion implantation.
Claim 23
Dependent Claim
45 words
The method of claim 18 wherein the fluency of ions used in step c) is in the range of about 1×10 14 and 1×10 18 ions/cm 2 and the accelerating energy used in step c) is in the range of about 10 and 1000 keV.
Claim 24
Dependent Claim
24 words
The method of claim 19 wherein the implant body is an occlusion coil or a stent and the protein is a cell adhesion protein.
References Cited (Backward Citations)
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