US5308704A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cell adhesive material and method for producing same
Assignee: Compaction Technology Soil Ltd
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Filing: 1992-08-19
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Granted: 1994-05-03
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Expires: 2012-08-19
Abstract
Abstract A cell adhesive material with excellent cell adhesion and cell proliferating property and a method for producing the same are provided. The adhesion and proliferation of cells can be improved remarkably by the surface modification of a cell adhesive material comprising a polymer material containing carbon as a constituting element, such as polystyrene or segmented polyurethane, wherein at least a part of the surface is modified by ion bombardment through ion implantation. The method for producing such cell adhesive material comprises implanting ions into at least a part of the surface of the polymer material. The cell adhesive material and the method for producing the same are promising for application to cell culture petri dishes and hybrid-type medicinal materials.
Inventors
- 👤 Yoshiaki Suzuki
- 👤 Masahiro Kusakabe
- 👤 Jae-Suk Lee
- 👤 Makoto Kaibara
- 👤 Masaya Iwaki
- 👤 Hiroyuki Sasabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:51
CPC Classifications
B; B29; B29C; B29C59/00; B29C59/16; B29C35/00; B29C35/02; B29C35/08; B29C35/0866; B29C2035/0872; B29K; B29K2025/00; B29K2075/00; Y; Y10; Y10T; Y10T428/00; Y10T428/31; Y10T428/315; Y10T428/31504; Y10T428/31551; Y10T428/31855
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
42 words
A cell adhesive material comprising a polymer material containing carbon as a constituting element, the polymer having a surface which has been modified by ions implanted into the polymer surface by ion bombardment thereby causing cells to adhere to the modified surface.
Claim 2
Dependent Claim
42 words
A cell adhesive material comprising a polymer material containing carbon as a constituting element, the polymer having a surface which has been modified by ions implanted into the polymer surface by ion bombardment thereby causing cells to adhere to the modified surface.
Claim 3
Dependent Claim
17 words
The cell adhesive material according to claim 1, wherein the polymer material is polystyrene or segmented polyurethane.
Claim 4
Dependent Claim
35 words
The cell adhesive material according to claim 2, wherein the segmented polyurethane is composed of a soft segment comprising polytetramethylene oxide and a dimethyl polysiloxane compound and a hard segment comprising diphenylmethane-4,4-diisocyanate and ethylene glycol.
Claim 5
Dependent Claim
32 words
The cell adhesive material according to claim 1, wherein the surface modifying layer contains at least one of >C═O group, a condensed ring, C--C bond, C--O bond, --OH group, and Si--H bond.
Claim 6
Independent Claim
39 words
A method for producing a cell adhesive material, comprising implanting ions in a range of 1×10 15 ≦φ<1×10 18 ions/cm 2 into at least a part of the surface of a polymer material containing carbon as a constituting element.
Claim 7
Independent Claim
39 words
A method for producing a cell adhesive material, comprising implanting ions in a range of 1×10 15 ≦φ<1×10 18 ions/cm 2 into at least a part of the surface of a polymer material containing carbon as a constituting element.
Claim 8
Dependent Claim
21 words
The method for producing a cell adhesive material according to claim 5, wherein the polymer material is polystyrene or segmented polyurethane.
Claim 9
Dependent Claim
39 words
The method for producing a cell adhesive material according to claim 6, wherein the segmented polyurethane is composed of a soft segment comprising polytetramethylene oxide and a dimethyl polysiloxane compound and a hard segment comprising diphenylmethane-4,4-diisocyanate and ethylene glycol.
Claim 10
Dependent Claim
48 words
The method for producing a cell adhesive material according to claim 5, wherein the ion species to be introduced is at least one of He + , N + , Ne + , Na + , N 2 + , O 2 + , and Kr + .
Claim 11
Dependent Claim
22 words
The method for producing a cell adhesive material according to claim 5, wherein the ion accelerating energy is 50 to 500 keV.
Claim 12
Dependent Claim
27 words
The method for producing a cell adhesive material according to claim 5, wherein the beam current density of the implanted ions is 0.5 μA/cm 2 or less.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-05-02 | 1997-11-01 | 1998-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-02 | 2001-11-01 | 2002-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-05-02 | 2005-11-01 | 2006-05-03 | $7700.00 | Window Closed / Lapsed |