Patent US5843093A successfully refreshed from Google Patents.
US5843093A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stereotactic electrode assembly
Assignee: University of Iowa Research Foundation
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Filing: 1995-10-27
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Granted: 1998-12-01
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Expires: 2015-10-27
Abstract
Abstract A neural prosthetic device for an auditory cortex of a patient has a support arranged in the auditory cortex with a plurality of electrical contacts and is connected to a speech processor for receiving and processing audio information and outputting processed electrical signals. Each of the plurality of electrical contacts independently outputs electrical discharges in accordance with the processed electrical signals. The plurality of electrical contacts are arranged to approximately tonotopically match the auditory cortex. And, methods and apparatus for selectively treating or inactivating neurons within the brain of a patient. The apparatus includes a dual purpose multicontact neuron-monitoring electrode assembly and an introducer tube for introducing the electrode assembly within a patient in the vicinity of the target tissue. The apparatus and methods of the instant invention are particularly suited to performing magnetic pallidotomy for the treatment of Parkinson's disease.
Inventors
- 👤 Matthew A. Howard, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:44
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/148; A61F; A61F11/00; A61F11/04; A61F11/20; A61F5/00; A61F5/0003; A61F5/0013; A61F5/0026; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/0526; A61N1/0529; A61N1/0531; A61N1/0539; A61N1/18; A61N1/32; A61N1/326; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36082; A61B2018/00315; A61B2018/00434; A61B2018/00571; A61B2018/00577; A61B2018/00636; A61B2018/00773; A61B2018/00839; A61B90/00; A61B90/10; A61M2210/00; A61M2210/06; A61M2210/0693; A61M27/00; A61M27/002; A61M27/006; A61M5/1428; A61M5/168; A61M5/172; A61M5/1723; A61N1/0541
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
135 words
A neurological apparatus comprising: an electrode support shaft; at least one bipolar neuron-monitoring microelectrode arranged along said electrode support shaft; and at least one lesion-producing macroelectrode arranged along said electrode support shaft, wherein said electrode support shaft comprises a flexible outer sheath, each of said at least one bipolar neuron-monitoring microelectrodes comprises a pair of electrical contacts, said pair of electrical contacts closely juxtaposed, each of said bipolar neuron-monitoring microelectrodes lying external to said flexible outer sheath of said electrode support shaft, wherein each of said pair of electrical contacts is constructed to monitor electrical activity produced by between one and ten neurons, and wherein each pair of electrical contacts is configured to be coupled to a differential amplifier, said differential amplifier capable of outputting signals and monitoring the activity of at least one neuron.
Claim 2
Dependent Claim
135 words
A neurological apparatus comprising: an electrode support shaft; at least one bipolar neuron-monitoring microelectrode arranged along said electrode support shaft; and at least one lesion-producing macroelectrode arranged along said electrode support shaft, wherein said electrode support shaft comprises a flexible outer sheath, each of said at least one bipolar neuron-monitoring microelectrodes comprises a pair of electrical contacts, said pair of electrical contacts closely juxtaposed, each of said bipolar neuron-monitoring microelectrodes lying external to said flexible outer sheath of said electrode support shaft, wherein each of said pair of electrical contacts is constructed to monitor electrical activity produced by between one and ten neurons, and wherein each pair of electrical contacts is configured to be coupled to a differential amplifier, said differential amplifier capable of outputting signals and monitoring the activity of at least one neuron.
Claim 3
Independent Claim
98 words
An apparatus for performing pallidotomy on a patient's brain, comprising: a) an electrode support shaft having a distal tip; b) an introducing means for introducing said electrode support shaft into the patient's brain, said electrode support shaft housed within said introducing means; c) a separately monitoring means, on said electrode support shaft, for monitoring the physiological activity of individual neurons; d) an inactivating means, on said electrode support shaft, capable of inactivating neurons; and e) a retrieving means attached to said electrode support shaft for retrieving said electrode support shaft from the patient's brain into said introducing means.
Claim 4
Independent Claim
98 words
An apparatus for performing pallidotomy on a patient's brain, comprising: a) an electrode support shaft having a distal tip; b) an introducing means for introducing said electrode support shaft into the patient's brain, said electrode support shaft housed within said introducing means; c) a separately monitoring means, on said electrode support shaft, for monitoring the physiological activity of individual neurons; d) an inactivating means, on said electrode support shaft, capable of inactivating neurons; and e) a retrieving means attached to said electrode support shaft for retrieving said electrode support shaft from the patient's brain into said introducing means.
Claim 5
Dependent Claim
53 words
The apparatus according to claim 2, wherein said electrode support shaft bears a magnet fixedly attached to the distal tip of said electrode support shaft, wherein said magnet is responsive to an applied external magnetic field, and wherein said introducing means comprises an introducer tube, and said retrieving means comprises a tether line.
Claim 6
Dependent Claim
44 words
The apparatus according to claim 38, wherein said monitoring means comprises at least one bipolar neuron-monitoring microelectrode, said inactivating means is selected from the group consisting of a lesion-producing macroelectrode, a cryogenic device, a neuron-stimulating electrode, and a means for delivering a chemical agent.
Claim 7
Dependent Claim
22 words
The apparatus according to claim 4, wherein said inactivating means comprises at least one lesion-producing macroelectrode capable of emitting radio frequency energy.
Claim 8
Dependent Claim
171 words
A neurological apparatus, comprising an introducer tube having a proximal end and a distal end and an electrode assembly, wherein said introducer tube comprises: an elongate cylindrical portion; a conical neck portion continuous with said elongate cylindrical portion, wherein said conical neck portion increases in diameter in a direction away from said elongate cylindrical portion; a short cylindrical end piece continuous with said conical neck portion; and means for sealing the proximal end of said introducer tube; and wherein said electrode assembly comprises: a flexible electrode support shaft having a distal portion and a distal tip; a magnet located at the distal tip of said flexible electrode support shaft, said magnet responsive to an applied magnetic field; at least one neuron-inactivating macroelectrode positioned on the distal portion of said flexible electrode support shaft; at least one neuron-monitoring microelectrode disposed on the distal portion of said flexible electrode support shaft; and a tether line attached to said flexible electrode support shaft at a location remote from said at least one neuron-monitoring microelectrode.
Claim 9
Dependent Claim
171 words
A neurological apparatus, comprising an introducer tube having a proximal end and a distal end and an electrode assembly, wherein said introducer tube comprises: an elongate cylindrical portion; a conical neck portion continuous with said elongate cylindrical portion, wherein said conical neck portion increases in diameter in a direction away from said elongate cylindrical portion; a short cylindrical end piece continuous with said conical neck portion; and means for sealing the proximal end of said introducer tube; and wherein said electrode assembly comprises: a flexible electrode support shaft having a distal portion and a distal tip; a magnet located at the distal tip of said flexible electrode support shaft, said magnet responsive to an applied magnetic field; at least one neuron-inactivating macroelectrode positioned on the distal portion of said flexible electrode support shaft; at least one neuron-monitoring microelectrode disposed on the distal portion of said flexible electrode support shaft; and a tether line attached to said flexible electrode support shaft at a location remote from said at least one neuron-monitoring microelectrode.
Claim 10
Dependent Claim
27 words
The apparatus according to claim 6, wherein each of said at least one neuron-monitoring microelectrode is spatially paired with each of said at least one neuron-inactivating macroelectrode.
Claim 11
Dependent Claim
17 words
The apparatus according to claim 6, wherein each of said at least one neuron-monitoring microelectrodes is multi-polar.
Claim 12
Dependent Claim
25 words
The apparatus according to claim 6, wherein each of said at least one neuron-monitoring microelectrode is bipolar and comprises a pair of juxtaposed electrical contacts.
Claim 13
Dependent Claim
33 words
The apparatus according to claim 6, wherein said at least one neuron-monitoring microelectrode monitors neuronal activity, and said neuronal activity is used to determine whether to energize said at least one neuron-inactivating macroelectrode.
Claim 14
Independent Claim
118 words
An apparatus for producing at least one lesion in a globus pallidus of a human brain, comprising: a flexible electrode support shaft having a magnetic tip responsive to an applied external magnetic field, wherein said flexible electrode support shaft is configured to be positioned along the globus pallidus in response to application of said external magnetic field; a plurality of lesion-producing macroelectrodes arranged along said flexible electrode support shaft; and a plurality of neuron-monitoring microelectrodes arranged along said flexible electrode support shaft, said plurality of neuron-monitoring microelectrodes for outputting neuron activity signals, and wherein selected lesion-producing macroelectrodes are energized, in accordance with said neuron activity signals outputted, to produce said at least one lesion in the globus pallidus.
Claim 15
Independent Claim
118 words
An apparatus for producing at least one lesion in a globus pallidus of a human brain, comprising: a flexible electrode support shaft having a magnetic tip responsive to an applied external magnetic field, wherein said flexible electrode support shaft is configured to be positioned along the globus pallidus in response to application of said external magnetic field; a plurality of lesion-producing macroelectrodes arranged along said flexible electrode support shaft; and a plurality of neuron-monitoring microelectrodes arranged along said flexible electrode support shaft, said plurality of neuron-monitoring microelectrodes for outputting neuron activity signals, and wherein selected lesion-producing macroelectrodes are energized, in accordance with said neuron activity signals outputted, to produce said at least one lesion in the globus pallidus.
Claim 16
Dependent Claim
35 words
The apparatus according to claim 1, wherein each of said plurality of neuron-monitoring microelectrodes is bipolar and has a defined spatial orientation on said flexible electrode support shaft relative to said plurality of lesion-producing macroelectrodes.
Claim 17
Dependent Claim
49 words
The apparatus according to claim 1, wherein each of said plurality of neuron-monitoring microelectrodes comprises a pair of juxtaposed electrical contacts and each of said plurality of neuron-monitoring microelectrodes is arranged on said flexible electrode support shaft coincidental with, and external to, each of said plurality of lesion-producing macroelectrodes.
Claim 18
Independent Claim
115 words
An apparatus for making one or more lesions in a brain, comprising: a flexible support shaft having a magnetic tip responsive to an external magnetic field, wherein said flexible support shaft can be precisely moved by application of an external magnetic field; a plurality of neuron-monitoring microelectrodes arranged along said flexible support shaft wherein each of the neuron-monitoring microelectrodes is constructed to sense electrical activity produced by between one and ten neurons; at least one lesion-producing macroelectrode disposed on said flexible support shaft; and a fluid-coated introducer tube for introducing said flexible support shaft into the brain, thereby allowing said at least one lesion-producing macroelectrode to make said one or more lesions in the brain.
Claim 19
Independent Claim
115 words
An apparatus for making one or more lesions in a brain, comprising: a flexible support shaft having a magnetic tip responsive to an external magnetic field, wherein said flexible support shaft can be precisely moved by application of an external magnetic field; a plurality of neuron-monitoring microelectrodes arranged along said flexible support shaft wherein each of the neuron-monitoring microelectrodes is constructed to sense electrical activity produced by between one and ten neurons; at least one lesion-producing macroelectrode disposed on said flexible support shaft; and a fluid-coated introducer tube for introducing said flexible support shaft into the brain, thereby allowing said at least one lesion-producing macroelectrode to make said one or more lesions in the brain.
Claim 20
Dependent Claim
24 words
The apparatus of claim 14, wherein said at least one lesion-producing macroelectrode comprises a plurality of lesion-producing macroelectrodes arranged along said flexible support shaft.
Claim 21
Dependent Claim
18 words
The apparatus of claim 15, wherein said plurality of lesion-producing macroelectrodes are capable of emitting radio frequency energy.
Claim 22
Dependent Claim
117 words
A neurological apparatus, comprising: a flexible electrode assembly including an electrode support shaft, said electrode support shaft having a magnetic tip which is responsive to the presence of an external magnetic field; one or more lesion-producing macroelectrodes arranged along said electrode support shaft; an introducer tube for introducing said electrode support shaft into a brain such that said magnetic tip is approximately in a desired location within the brain; and a plurality of neuron-monitoring microelectrodes arranged along said electrode support shaft, wherein each neuron-monitoring microelectrode is constructed to sense the electrical activity produced by between one and ten neurons, and wherein said electrode support shaft is movable within the brain by application of an external magnetic field.
Claim 23
Dependent Claim
117 words
A neurological apparatus, comprising: a flexible electrode assembly including an electrode support shaft, said electrode support shaft having a magnetic tip which is responsive to the presence of an external magnetic field; one or more lesion-producing macroelectrodes arranged along said electrode support shaft; an introducer tube for introducing said electrode support shaft into a brain such that said magnetic tip is approximately in a desired location within the brain; and a plurality of neuron-monitoring microelectrodes arranged along said electrode support shaft, wherein each neuron-monitoring microelectrode is constructed to sense the electrical activity produced by between one and ten neurons, and wherein said electrode support shaft is movable within the brain by application of an external magnetic field.
Claim 24
Dependent Claim
51 words
The apparatus according to claim 17, wherein said one or more lesion-producing macroelectrodes is spatially paired with one of said plurality of neuron-monitoring microelectrodes arranged along said electrode support shaft, and each of said plurality of lesion-producing macroelectrodes is capable of inactivating one or more neurons by emitting radio frequency energy.
Claim 25
Dependent Claim
53 words
A neurological apparatus comprising: an electrode support shaft having a magnetic tip; at least one monopolar or multipolar neuron-monitoring microelectrode arranged along said electrode support shaft each microelectrode being configured to monitor the electrical activity of between one and ten neurons; and at least one lesion-producing macroelectrode arranged along said electrode support shaft.
Claim 26
Dependent Claim
53 words
A neurological apparatus comprising: an electrode support shaft having a magnetic tip; at least one monopolar or multipolar neuron-monitoring microelectrode arranged along said electrode support shaft each microelectrode being configured to monitor the electrical activity of between one and ten neurons; and at least one lesion-producing macroelectrode arranged along said electrode support shaft.
Claim 27
Dependent Claim
14 words
The apparatus of claim 19, wherein said electrode support shaft comprises a flexible sheath.
Claim 28
Dependent Claim
44 words
A neurological apparatus comprising: a support shaft; at least one monopolar neuron-monitoring microelectrode arranged along said support shaft each microelectrode being configured to monitor the electrical activity of between one and ten neurons; and at least one lesion-producing macroelectrode arranged along said support shaft.
Claim 29
Dependent Claim
44 words
A neurological apparatus comprising: a support shaft; at least one monopolar neuron-monitoring microelectrode arranged along said support shaft each microelectrode being configured to monitor the electrical activity of between one and ten neurons; and at least one lesion-producing macroelectrode arranged along said support shaft.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-30 | 2002-06-01 | 2002-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-30 | 2006-06-01 | 2006-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-30 | 2010-06-01 | 2010-12-01 | $7700.00 | Window Closed / Lapsed |