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US5837859A
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Preparation of a electronically conductive polymer/nucleotide copolymer
Assignee: Commissariat à l'Énergie Atomique et Aux Énergies Alternatives
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Filing: 1994-03-30
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Granted: 1998-11-17
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Expires: 2014-03-30
Abstract
Abstract PCT No. PCT/FR94/00354 Sec. 371 Date Sep. 22, 1995 Sec. 102(e) Date Sep. 22, 1995 PCT Filed Mar. 30, 1994 PCT Pub. No. WO94/22889 PCT Pub. Date Oct. 13, 1994A copolymer of general formula (I), <IMAGE> (I) wherein unit A is a monomer of an electronically conductive polymer, unit B is a nucleotide, an oligonucleotide or an analogue thereof, x, y, z are integers of 1 or higher or y is 0, and l is a covalent bond, or a spacer arm. Methods for preparing said polymer and its use, in particular for nucleic acid synthesis, sequencing and hybridization, are also disclosed.
Inventors
- 👤 Robert Teoule
- 👤 Andre Roget
- 👤 Thierry Livache
- 👤 Christelle Barthet
- 👤 Gerard Bidan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:43
CPC Classifications
C; C07; C07H; C07H21/00; C08; C08G; C08G61/00; C08G61/12; C08G61/122; C08G61/123; C08G61/124; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/6825; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00709; B01J2219/00713
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
101 words
A process for preparing an electrically conductive copolymer represented by general formula (1): ##STR5## comprising copolymerizing a monomer represented by formula (IV): ##STR6## with a polymerizable monomer represented by the formula A, wherein said monomer A produces an electrically conductive polymer when polymerized, and represents a polymerized unit of said monomer A in the electrically conductive copolymer, represents either (1) a nucleotide unit or an analog thereof, or (2) an oligonucleotide unit or an analog thereof, x, y and z each, independently, represents an integer equal to or greater than 1, and l represents a covalent bond or a spacer arm.
Claim 2
Dependent Claim
101 words
A process for preparing an electrically conductive copolymer represented by general formula (1): ##STR5## comprising copolymerizing a monomer represented by formula (IV): ##STR6## with a polymerizable monomer represented by the formula A, wherein said monomer A produces an electrically conductive polymer when polymerized, and represents a polymerized unit of said monomer A in the electrically conductive copolymer, represents either (1) a nucleotide unit or an analog thereof, or (2) an oligonucleotide unit or an analog thereof, x, y and z each, independently, represents an integer equal to or greater than 1, and l represents a covalent bond or a spacer arm.
Claim 3
Dependent Claim
12 words
The process of claim 1, wherein the copolymerization is an electrochemical copolymerization.
Claim 4
Dependent Claim
16 words
The process of claim 2, further comprising coupling additional units to the units of the copolymer.
Claim 5
Dependent Claim
23 words
The process of claim 3, wherein the coupling of additional units to the units of the copolymer comprises at least one electrochemical reaction.
Claim 6
Dependent Claim
16 words
The process of claim 4, wherein the copolymerization is conducted on the surface of an electrode.
Claim 7
Dependent Claim
10 words
The process of claim 1 wherein A is a pyrrole.
Claim 8
Dependent Claim
21 words
The method of claim 1, wherein A is acetylene, azine, p-phenylene, p-phenylene vinylene, pyrene, thiophene, furan, selenophene, pyridazine, carbazole or aniline.
Claim 9
Dependent Claim
14 words
The method of claim 1, wherein the ratio x/y is between 1/5 and 1/100,000.
Claim 10
Dependent Claim
121 words
The method of claim 1, wherein l is a spacer arm represented by the formula: --R.sub.1 -- (CH.sub.2).sub.n --R.sub.2 !.sub.x -- CH.sub.2).sub.m --R.sub.3 !.sub.y --(CH.sub.2).sub.p -- wherein n is an integer from 1 to 10; m is 0 or an integer from 1 to 10; p is 0 or an integer from 1 to 10; x is 0 or an integer from 1 to 8; y is 0 or an integer from 1 to 8; R 1 , R 2 and R 3 , which may be identical or different, represent: CH 2 , O, S, NR', CO, CH═CH, NR'CO, CONR', NHSO 2 , or ##STR7## where R' represents a hydrogen atom or a C 1 to C 12 alkyl group.
References Cited (Backward Citations)
EP0314009A2
Cited
WO1991008307A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-16 | 2002-05-18 | 2002-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-16 | 2006-05-18 | 2006-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-16 | 2010-05-18 | 2010-11-17 | $7700.00 | Window Closed / Lapsed |