US5834309A
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Vertebrate apoptosis gene: compositions and methods
Assignee: Arch Development Corp
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Filing: 1995-06-06
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Granted: 1998-11-10
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Expires: 2015-06-06
Abstract
Abstract The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
Inventors
- 👤 Craig B. Thompson
- 👤 Lawrence H. Boise
- 👤 Gabriel Nunez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:48
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4747; A; A61; A61P; A61P35/00; A61P43/00; C07K14/465
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
11 words
An isolated and purified polynucleotide that encodes a BCL-X S polypeptide.
Claim 2
Dependent Claim
11 words
An isolated and purified polynucleotide that encodes a BCL-X S polypeptide.
Claim 3
Dependent Claim
15 words
The isolated and purified polynucleotide of claim 1, wherein said polynucleotide is a DNA molecule.
Claim 4
Dependent Claim
19 words
The DNA molecule of claim 2, wherein said encoded polypeptide comprises the amino acid sequences of SEQ ID NO:9.
Claim 5
Dependent Claim
20 words
The isolated and purified polynucleotide of claim 1, wherein said polynucleotide comprises the nucleotide base sequence of SEQ ID NO:8.
Claim 6
Dependent Claim
29 words
An isolated and purified polynucleotide comprising a nucleotide base sequence that is identical or complementary to a segment of at least 15 contiguous nucleotide bases of SEQ ID No:8.
Claim 7
Dependent Claim
29 words
An isolated and purified polynucleotide comprising a nucleotide base sequence that is identical or complementary to a segment of at least 15 contiguous nucleotide bases of SEQ ID No:8.
Claim 8
Dependent Claim
12 words
An expression vector comprising a polynucleotide that encodes a BCL-X S polypeptide.
Claim 9
Dependent Claim
12 words
An expression vector comprising a polynucleotide that encodes a BCL-X S polypeptide.
Claim 10
Dependent Claim
15 words
The expression vector of claim 6, wherein the polynucleotide is operatively linked to an enhancer-promoter.
Claim 11
Dependent Claim
14 words
A recombinant host cell transfected with a polynucleotide that encodes a BCL-X S polypeptide.
Claim 12
Dependent Claim
14 words
A recombinant host cell transfected with a polynucleotide that encodes a BCL-X S polypeptide.
Claim 13
Dependent Claim
24 words
The recombinant host cell of claim 8 wherein the polynucleotide is operatively linked to transcriptional control regulatory sequences that are functional in said cell.
References Cited (Backward Citations)
EP0252685A2
Cited
US5082774A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-09 | 2002-05-11 | 2002-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-09 | 2006-05-11 | 2006-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-09 | 2010-05-11 | 2010-11-10 | $7700.00 | Window Closed / Lapsed |