Patent US5831014A successfully refreshed from Google Patents.
US5831014A
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PNA combinatorial libraries and improved methods of synthesis
Assignee: Ionis Pharmaceuticals Inc
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Filing: 1995-02-22
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Granted: 1998-11-03
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Expires: 2015-02-22
Abstract
Abstract New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are methods of making random libraries of peptide nucleic acids using the fully preformed monomers.
Inventors
- 👤 Phillip Dan Cook
- 👤 John Kiely
- 👤 Kelly Sprankle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:34
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/001; C07K14/003; C07K7/00; C07K7/02; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00583; B01J2219/00592; B01J2219/00718; B01J2219/0072; B01J2219/00729
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
68 words
A compound of the structure: AA!.sub.w --{ PNA!.sub.u -- AA!.sub.v }.sub.x -- PNA!.sub.y -- AA!.sub.z wherein each AA, independently, is an amino acid residue; each PNA, independently, is a peptide amino acid residue; u, v, x and y, independently, are 1 to 500; w is 0 to 500; z is 3 to 500; and the sum of u, v, w, x, y and z is less than 500.
Claim 2
Dependent Claim
68 words
A compound of the structure: AA!.sub.w --{ PNA!.sub.u -- AA!.sub.v }.sub.x -- PNA!.sub.y -- AA!.sub.z wherein each AA, independently, is an amino acid residue; each PNA, independently, is a peptide amino acid residue; u, v, x and y, independently, are 1 to 500; w is 0 to 500; z is 3 to 500; and the sum of u, v, w, x, y and z is less than 500.
Claim 3
Dependent Claim
20 words
A compound of claim 1 wherein the sum of u, v, w, x, y and z is less than 100.
Claim 4
Dependent Claim
20 words
A compound of claim 1 wherein the sum of u, v, w, x, y and z is less than 25.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-02 | 2002-05-04 | 2002-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-02 | 2006-05-04 | 2006-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-02 | 2010-05-04 | 2010-11-03 | $7700.00 | Window Closed / Lapsed |