Patent US5810762A successfully refreshed from Google Patents.
US5810762A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electroporation system with voltage control feedback for clinical applications
Assignee: OncoSec Medical Inc
•
Filing: 1995-04-10
•
Granted: 1998-09-22
•
Expires: 2015-04-10
Abstract
Abstract An electrode apparatus for the application of electroporation to a portion of the body of a patient, comprising a support member, a pair of electrodes adjustably mounted on the support member for movement toward and away from one another for positioning on opposite sides of a body portion to be electroporated, a sensing element for sensing a distance between the electrodes and generating a distance signal proportionate to the distance between the electrodes, and means responsive to said distance signal for applying pulses of high amplitude electric energy to the electrodes proportionate to the distance between the electrodes.
Inventors
- 👤 Gunter A. Hofmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:46
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/327; A61N1/325
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
133 words
An apparatus for the therapeutic application of electroporation to a portion of the body of a patient, comprising: an electrode assembly including a support member and a pair of adjustably spaced electrodes on said support member for adjustably positioning into engagement with and for generating an electric field at a preselected location within a body of a patient; means for sensing and generating a distance signal proportionate to the space between said electrodes; and a pulse generator including means responsive to said distance signal for applying an electric signal to the electrodes proportionate to the space between said electrodes for repeatedly generating electric fields of a predetermined amplitude and duration for forcing the walls of preselected cells in the body portion to be transiently permeable for enabling molecules to enter said preselected cells.
Claim 2
Independent Claim
133 words
An apparatus for the therapeutic application of electroporation to a portion of the body of a patient, comprising: an electrode assembly including a support member and a pair of adjustably spaced electrodes on said support member for adjustably positioning into engagement with and for generating an electric field at a preselected location within a body of a patient; means for sensing and generating a distance signal proportionate to the space between said electrodes; and a pulse generator including means responsive to said distance signal for applying an electric signal to the electrodes proportionate to the space between said electrodes for repeatedly generating electric fields of a predetermined amplitude and duration for forcing the walls of preselected cells in the body portion to be transiently permeable for enabling molecules to enter said preselected cells.
Claim 3
Dependent Claim
21 words
An apparatus according to claim 1 wherein said electrode assembly comprise forceps having moveable clamping jaws defined by said spaced electrodes.
Claim 4
Dependent Claim
14 words
An apparatus according to claim 2 wherein the forceps are insertable through a tube.
Claim 5
Dependent Claim
54 words
An apparatus according to claim 3 wherein the forceps comprise a central shaft portion, said clamping jaws on one end of said shaft portion, a handle with actuating means on the other end, and said means for sensing the distance between said electrodes includes means for sensing the relative position of said actuating means.
Claim 6
Dependent Claim
60 words
An apparatus according to claim 1 wherein said electrode assembly comprises guide means supporting said electrodes for movement toward and away from one another, a rotating screw on said support member operatively connected for moving said electrodes, a manually operable wheel for rotating said screw and said means for sensing is a rheostat drivingly connected for rotating with said screw.
Claim 7
Dependent Claim
38 words
An apparatus according to claim 1 wherein the electric signal has a wave form selected from the group consisting of an exponentially decaying pulse, a square pulse, a unipolar oscillating pulse train and a bipolar oscillating pulse train.
Claim 8
Dependent Claim
21 words
An apparatus according to claim 1 wherein the electric field has a strength of between approximately 0.2 kV/cm and 20.0 kV/cm.
Claim 9
Dependent Claim
21 words
An apparatus according to claim 7 wherein each pulse has a duration of between approximately ten microseconds and one hundred milliseconds.
Claim 10
Dependent Claim
23 words
An apparatus according to claim 7 wherein the field applies between approximately one pulse and one hundred pulses to a given tissue volume.
Claim 11
Dependent Claim
17 words
An apparatus according to claim 1 wherein said electrodes detachably mount in sockets on said support means.
Claim 12
Independent Claim
132 words
A method for the therapeutic application of electroporation to a portion of the body of a patient for introducing molecules into cells therein, comprising: providing electrode means including adjustably spaced electrodes for generating an electric field at a preselected location within a body of a patient; sensing the distance between said electrodes and generating a signal proportionate to the distance between said electrodes; and providing an electric pulse generator connected to said electrode means operating said pulse generator for applying an electric signal to said electrodes proportionate to the distance between said electrodes for causing said electrodes to repeatedly generate electric fields of a predetermined amplitude and duration thereby forcing the walls of preselected cells in the body portion to be transiently permeable for permitting the molecules to enter said preselected cells.
Claim 13
Independent Claim
132 words
A method for the therapeutic application of electroporation to a portion of the body of a patient for introducing molecules into cells therein, comprising: providing electrode means including adjustably spaced electrodes for generating an electric field at a preselected location within a body of a patient; sensing the distance between said electrodes and generating a signal proportionate to the distance between said electrodes; and providing an electric pulse generator connected to said electrode means operating said pulse generator for applying an electric signal to said electrodes proportionate to the distance between said electrodes for causing said electrodes to repeatedly generate electric fields of a predetermined amplitude and duration thereby forcing the walls of preselected cells in the body portion to be transiently permeable for permitting the molecules to enter said preselected cells.
Claim 14
Dependent Claim
24 words
A method according to claim 11 wherein the electrode means are selected to comprise forceps having moveable clamping jaws defined by said spaced electrodes.
Claim 15
Dependent Claim
14 words
A method according to claim 12 wherein the forceps are insertable through a tube.
Claim 16
Dependent Claim
57 words
A method according to claim 13 wherein said forceps are selected to comprise a central shaft portion, said clamping jaws on one end of said shaft portion, a handle with actuating means on the other end, and said means for sensing the distance between said electrodes includes means for sensing the relative position of said actuating means.
Claim 17
Dependent Claim
63 words
A method according to claim 11 wherein said electrode assembly is selected to comprises guide means supporting said electrodes for movement toward and away from one another, a rotating screw on said support member operatively connected for moving said electrodes, a manually operable wheel for rotating said screw and said means for sensing is a rheostat drivingly connected for rotating with said screw.
Claim 18
Dependent Claim
28 words
A method according to claim 15 wherein said pulse generator is operated for generating an electric field having a strength of between approximately 0.2 kV/cm and 20 kV/cm.
Claim 19
Dependent Claim
45 words
A method according to claim 16 wherein said pulse generator is detected to generate an electric signal having a wave form selected from the group consisting of an exponentially decaying pulse, a square pulse, a unipolar oscillating pulse train and a bipolar oscillating pulse train.
Claim 20
Dependent Claim
44 words
A method according to claim 11 wherein said electrode means is selected to comprise a first plurality of needles mounted in a first clamp fixed on said holder and a second plurality of needles mounted in a second clamp movably mounted on said holder.
Claim 21
Dependent Claim
38 words
A method according to claim 18 wherein the electric signal has a wave form selected from the group consisting of an exponentially decaying pulse, a square pulse, a unipolar oscillating pulse train and a bipolar oscillating pulse train.
Claim 22
Dependent Claim
21 words
A method according to claim 19 wherein the electric field has a strength of between approximately 0.2 kV/cm and 20.0 kV/cm.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-09-21 | 2002-03-23 | 2002-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-09-21 | 2006-03-23 | 2006-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-09-21 | 2010-03-23 | 2010-09-22 | $7700.00 | Window Closed / Lapsed |