US5800486A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for transurethral thermal therapy with cooling balloon
Assignee: Auslo Research LLC
•
Filing: 1996-06-17
•
Granted: 1998-09-01
•
Expires: 2016-06-17
Abstract
Abstract An intraurethral catheter includes an microwave antenna and a cooling lumen structure substantially surrounding the antenna. A cooling balloon partially surrounds the cooling lumens on one side of the catheter adjacent the microwave antenna. The cooling balloon improves wall contact between the catheter and a wall of the urethra to improve cooling of the urethra. The cooling balloon communicates with the cooling lumen structure to permit circulation of cooling fluid through the cooling balloon.
Inventors
- 👤 Scott P. Thome
- 👤 Jim Kauphusman
- 👤 Mitchell Dann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 00:29
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/1815; A61B17/00; A61B17/00234; A61B2017/00238; A61B2017/00274; A61B2018/00053; A61B2018/00166; A61B2018/00315; A61B2018/00547; A61M; A61M25/00; A61M25/0021; A61M25/0023; A61M25/0026; A61M2025/0036; A61M25/0032; A61M25/10; A61M25/1002
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
106 words
An intraurethral catheter for microwave thermal therapy comprising: an elongate shaft having a first end, a second end, an outer surface and a plurality of lumens which extend between the first end and the second end of the shaft, the plurality of lumens including: an antenna lumen; and a plurality of fluid flow lumens arranged about the antenna lumen and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft, the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with at least one of the plurality of fluid flow lumens.
Claim 2
Dependent Claim
106 words
An intraurethral catheter for microwave thermal therapy comprising: an elongate shaft having a first end, a second end, an outer surface and a plurality of lumens which extend between the first end and the second end of the shaft, the plurality of lumens including: an antenna lumen; and a plurality of fluid flow lumens arranged about the antenna lumen and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft, the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with at least one of the plurality of fluid flow lumens.
Claim 3
Dependent Claim
48 words
The intraurethral catheter of claim 1 wherein the plurality of fluid flow lumens further comprises a first and second pair of fluid flow lumens and the second pair of lumens has a transverse cross-sectional area substantially greater than a transverse cross-sectional area of the first pair of lumens.
Claim 4
Dependent Claim
27 words
The intraurethral catheter of claim 2 wherein the balloon is arranged so that the inflatable portion of the balloon is adjacent the second pair of cooling lumens.
Claim 5
Dependent Claim
55 words
The intraurethral catheter of claim 3 wherein an inner wall of the inflatable portion of the balloon is common with a wall defining an outer wall of the second pair of fluid flow lumens so that a majority of the inflatable portion of the balloon is immediately adjacent the second pair of fluid flow lumens.
Claim 6
Dependent Claim
34 words
The intraurethral catheter of claim 1, and further comprising an electromagnetic radiation antenna within a portion of the antenna lumen of the shaft, the portion of the antenna lumen being adjacent to the balloon.
Claim 7
Dependent Claim
27 words
The intraurethral catheter of claim 5 wherein the balloon has a length greater than a length of the portion of the antenna lumen which contains the antenna.
Claim 8
Dependent Claim
27 words
The intraurethral catheter of claim 5 wherein the balloon has a length less than a length of the portion of the antenna lumen which contains the antenna.
Claim 9
Dependent Claim
22 words
The intraurethral catheter of claim 1 wherein the balloon has a length substantially less than an entire length of a prostatic urethra.
Claim 10
Dependent Claim
29 words
The intraurethral catheter of claim 8 wherein the balloon has a length substantially equal to a length of the prostatic urethra proximal to a verumontanum of the prostatic urethra.
Claim 11
Dependent Claim
33 words
The intraurethral catheter of claim 1 wherein the antenna lumen is adapted to prevent fluid communication between the antenna lumen and the fluid flow lumens and between the antenna lumen and the balloon.
Claim 12
Dependent Claim
102 words
An intraurethral catheter for microwave thermal therapy comprising: an elongate shaft having a first end, a second end, an outer surface and a plurality of lumens which extend between the first end and the second end of the shaft, the plurality of lumens including: an antenna lumen; a plurality of fluid flow lumens arranged about the antenna lumen; and an inflation lumen; and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft, the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with the inflation lumen.
Claim 13
Dependent Claim
102 words
An intraurethral catheter for microwave thermal therapy comprising: an elongate shaft having a first end, a second end, an outer surface and a plurality of lumens which extend between the first end and the second end of the shaft, the plurality of lumens including: an antenna lumen; a plurality of fluid flow lumens arranged about the antenna lumen; and an inflation lumen; and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft, the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with the inflation lumen.
Claim 14
Independent Claim
182 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; means within the catheter disposed between the radiating means and the outer surface of the catheter on both the first and second sides of the catheter for preventing necrosis of the surface of the first and second urethral walls; and a balloon positioned along a portion of the catheter adjacent to the radiating means the balloon being connected to the outer surface of the catheter and having an inflatable portion partially surrounding the radiation means on the second side of the catheter in fluid communication with the means for preventing necrosis of the surface of the first and second urethral walls.
Claim 15
Independent Claim
182 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; means within the catheter disposed between the radiating means and the outer surface of the catheter on both the first and second sides of the catheter for preventing necrosis of the surface of the first and second urethral walls; and a balloon positioned along a portion of the catheter adjacent to the radiating means the balloon being connected to the outer surface of the catheter and having an inflatable portion partially surrounding the radiation means on the second side of the catheter in fluid communication with the means for preventing necrosis of the surface of the first and second urethral walls.
Claim 16
Dependent Claim
21 words
The device of claim 12 wherein the balloon has a length substantially less than an entire length of a prostatic urethra.
Claim 17
Dependent Claim
28 words
The device of claim 13 wherein the balloon has a length substantially equal to a length of the prostatic urethra proximal to a verumontanum of the prostatic urethra.
Claim 18
Dependent Claim
109 words
An intraurethral catheter for microwave therapy comprising: an elongate shaft having a first end, a second end, an outer surface, and a plurality of lumens extending between the first end and the second end, the plurality of lumens including: an antenna lumen; and a first fluid flow lumen and a second fluid flow lumen arranged in a side by side relationship and partially surrounding the antenna lumen; and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with the second fluid flow lumen.
Claim 19
Dependent Claim
109 words
An intraurethral catheter for microwave therapy comprising: an elongate shaft having a first end, a second end, an outer surface, and a plurality of lumens extending between the first end and the second end, the plurality of lumens including: an antenna lumen; and a first fluid flow lumen and a second fluid flow lumen arranged in a side by side relationship and partially surrounding the antenna lumen; and a balloon connected to the outer surface of the elongate shaft along a portion of the shaft the balloon having an inflatable portion which partially surrounds the antenna lumen and which is in fluid communication with the second fluid flow lumen.
Claim 20
Dependent Claim
51 words
The intraurethral catheter of claim 15 wherein an inner wall of the inflatable portion of the balloon is common with a wall defining an outer wall of the second fluid flow lumen so that a majority of the inflatable portion of the balloon is immediately adjacent the second fluid flow lumen.
Claim 21
Independent Claim
259 words
A method for treating diseased tissue adjacent a conduit comprising: inserting a catheter into a body conduit system including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens; advancing the catheter through the conduit system with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the conduit; positioning the catheter so that a first side of the catheter is immediately adjacent the tissue to be treated and a second side of the catheter is adjacent healthy tissue; inflating the inflatable portion of the balloon so that the balloon established substantially uniform wall contact between the outer surface of the catheter and the bodily conduit without distorting a shape of the bodily conduit along its entire length and cools a surface of the bodily conduit; and heating a portion of tissue beyond the surface of the bodily conduit with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the tissue portion while cooling the conduit surface adjacent the first side of the catheter with fluid flowing through the fluid flow lumens and cooling the conduit surface adjacent the second side of the catheter with fluid flowing through the balloon and the fluid flow lumens.
Claim 22
Independent Claim
259 words
A method for treating diseased tissue adjacent a conduit comprising: inserting a catheter into a body conduit system including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens; advancing the catheter through the conduit system with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the conduit; positioning the catheter so that a first side of the catheter is immediately adjacent the tissue to be treated and a second side of the catheter is adjacent healthy tissue; inflating the inflatable portion of the balloon so that the balloon established substantially uniform wall contact between the outer surface of the catheter and the bodily conduit without distorting a shape of the bodily conduit along its entire length and cools a surface of the bodily conduit; and heating a portion of tissue beyond the surface of the bodily conduit with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the tissue portion while cooling the conduit surface adjacent the first side of the catheter with fluid flowing through the fluid flow lumens and cooling the conduit surface adjacent the second side of the catheter with fluid flowing through the balloon and the fluid flow lumens.
Claim 23
Independent Claim
148 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; first cooling means within the catheter disposed between the radiating means and the outer surface of the catheter on both the first side and the second side of the catheter for cooling the urethra and for absorbing a first amount of the emission; and second cooling means partially surrounding the radiating means on the second side of the catheter for cooling the urethra without absorbing the emission.
Claim 24
Independent Claim
148 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; first cooling means within the catheter disposed between the radiating means and the outer surface of the catheter on both the first side and the second side of the catheter for cooling the urethra and for absorbing a first amount of the emission; and second cooling means partially surrounding the radiating means on the second side of the catheter for cooling the urethra without absorbing the emission.
Claim 25
Dependent Claim
32 words
The device of claim 18 wherein the emission is a microwave emission and the intraurethral catheter further comprises: an inflation lumen for supplying a non-microwave-absorbing cooling fluid to the second cooling means.
Claim 26
Independent Claim
168 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; first cooing means within the catheter disposed between the radiating means and the outer surface of the catheter on the first side of the catheter for cooling the urethra and for absorbing a first amount of the emission; and second cooling means partially surrounding around the radiating means on the second side of the catheter and having an inner portion adapted for cooling the urethra and for absorbing a second amount of the emission and an outer portion adapted for cooling the urethra without absorbing the emission.
Claim 27
Independent Claim
168 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first side for orientation toward a first wall of the urethra, and a second side for orientation toward a second wall of the urethra; radiating means within the catheter for producing an emission capable of necrosing target prostatic tissue beyond a surface of the first and second walls of the urethra; first cooing means within the catheter disposed between the radiating means and the outer surface of the catheter on the first side of the catheter for cooling the urethra and for absorbing a first amount of the emission; and second cooling means partially surrounding around the radiating means on the second side of the catheter and having an inner portion adapted for cooling the urethra and for absorbing a second amount of the emission and an outer portion adapted for cooling the urethra without absorbing the emission.
Claim 28
Dependent Claim
36 words
The device of claim 20 wherein the emission is a microwave emission and the intraurethral catheter further comprises: an inflation lumen for supplying a non-microwave-absorbing cooling fluid to the outer portion of the second cooling means.
Claim 29
Independent Claim
301 words
A method for treating a diseased portion of a prostate comprising: inserting a catheter into a urethra including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens and having a length substantially equal to a length of the urethra in the prostate proximal to a verumontanum of the urethra in the prostate; advancing the catheter through the urethra with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the urethra; positioning the catheter so that a first side of the catheter is immediately adjacent the diseased portion to be treated and a second side of the catheter is adjacent healthy tissue so that upon inflation the inflatable portion of the balloon establishes substantially uniform contact with a wall of the urethra from a point just proximal to the verumontanum of the urethra in the prostate to a point just proximal of a proximal end of the urethra in the prostate; cooling the urethra by directing cooling fluid to flow through the fluid flow lumens and the balloon to cool the urethra adjacent the first side of the catheter with cooling fluid flowing through the fluid flow lumens and to cool the urethra adjacent the second side of the catheter with cooling fluid flowing through the balloon and the fluid flow lumens; and heating the diseased portion beyond a surface of the urethra with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the diseased portion.
Claim 30
Independent Claim
301 words
A method for treating a diseased portion of a prostate comprising: inserting a catheter into a urethra including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens and having a length substantially equal to a length of the urethra in the prostate proximal to a verumontanum of the urethra in the prostate; advancing the catheter through the urethra with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the urethra; positioning the catheter so that a first side of the catheter is immediately adjacent the diseased portion to be treated and a second side of the catheter is adjacent healthy tissue so that upon inflation the inflatable portion of the balloon establishes substantially uniform contact with a wall of the urethra from a point just proximal to the verumontanum of the urethra in the prostate to a point just proximal of a proximal end of the urethra in the prostate; cooling the urethra by directing cooling fluid to flow through the fluid flow lumens and the balloon to cool the urethra adjacent the first side of the catheter with cooling fluid flowing through the fluid flow lumens and to cool the urethra adjacent the second side of the catheter with cooling fluid flowing through the balloon and the fluid flow lumens; and heating the diseased portion beyond a surface of the urethra with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the diseased portion.
Claim 31
Independent Claim
273 words
A method for treating a diseased portion of a prostate comprising: inserting a catheter into a urethra including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens and having a length substantially equal to a length of the urethra proximal to a verumontanum of the urethra in the prostate; advancing the catheter through the urethra with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the urethra; positioning the catheter so that a first side of the catheter is immediately adjacent the diseased portion to be treated and a second side of the catheter is adjacent healthy tissue; directing cooling fluid to flow through the fluid flow lumens and the balloon so that the balloon is inflated and causes stretching of the urethra radially establishing substantially uniform contact between the catheter and a wall of the urethra from a point just proximal to the verumontanum of the urethra in the prostate to a point just proximal of a proximal end of the urethra in the prostate; and heating the diseased portion beyond a surface of the urethra with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the diseased portion while cooling the urethra with the cooling fluid flowing through the fluid flow lumens and the balloon.
Claim 32
Independent Claim
273 words
A method for treating a diseased portion of a prostate comprising: inserting a catheter into a urethra including a microwave antenna disposed within an antenna lumen, a plurality of fluid flow lumens substantially surrounding the antenna lumen and a balloon connected to an outer surface of the catheter along a portion of the catheter and having an inflatable portion which partially surrounds the antenna lumen, the balloon being in fluid communication with the fluid flow lumens and having a length substantially equal to a length of the urethra proximal to a verumontanum of the urethra in the prostate; advancing the catheter through the urethra with the balloon in its deflated state until the microwave antenna is adjacent a diseased portion of tissue adjacent the urethra; positioning the catheter so that a first side of the catheter is immediately adjacent the diseased portion to be treated and a second side of the catheter is adjacent healthy tissue; directing cooling fluid to flow through the fluid flow lumens and the balloon so that the balloon is inflated and causes stretching of the urethra radially establishing substantially uniform contact between the catheter and a wall of the urethra from a point just proximal to the verumontanum of the urethra in the prostate to a point just proximal of a proximal end of the urethra in the prostate; and heating the diseased portion beyond a surface of the urethra with microwave energy from the microwave antenna at a power range and for a time sufficient to necrose the diseased portion while cooling the urethra with the cooling fluid flowing through the fluid flow lumens and the balloon.
Claim 33
Independent Claim
153 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first circumferential portion for orientation toward a first portion of a wall of the urethra, and a second circumferential portion for orientation toward a second portion of the wall of the urethra opposite the first portion of the wall of the urethra; radiation means within the catheter for producing an emission capable of necrosing target prostate tissue spaced from a surface of the wall of the urethra; first means within the catheter adjacent to the radiation means for preventing necrosis of the surface of the wall of the urethra; and a balloon connected to the outer surface of the catheter adjacent the radiation means, the balloon being configured to inflate on the second circumferential portion of the catheter partially surrounding the radiation means.
Claim 34
Independent Claim
153 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first circumferential portion for orientation toward a first portion of a wall of the urethra, and a second circumferential portion for orientation toward a second portion of the wall of the urethra opposite the first portion of the wall of the urethra; radiation means within the catheter for producing an emission capable of necrosing target prostate tissue spaced from a surface of the wall of the urethra; first means within the catheter adjacent to the radiation means for preventing necrosis of the surface of the wall of the urethra; and a balloon connected to the outer surface of the catheter adjacent the radiation means, the balloon being configured to inflate on the second circumferential portion of the catheter partially surrounding the radiation means.
Claim 35
Independent Claim
167 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first circumferential portion for orientation toward a first portion of a wall of the urethra, and a second circumferential portion for orientation toward a second portion of the wall of the urethra opposite the first portion of the wall of the urethra; radiation means within the catheter for producing an emission capable of necrosing target prostate tissue spaced from a surface of the wall of the urethra; first means within the catheter disposed between the radiating means and the outer surface of the catheter at both the first and second circumferential portions for preventing necrosis of the surface of the wall of the urethra; and a balloon connected to the outer surface of the catheter adjacent the radiation means, the balloon defining a chamber partially surrounding the radiation means on the second circumferential portion of the catheter.
Claim 36
Independent Claim
167 words
A device for treatment of BPH comprising: an intraurethral catheter adapted to be inserted into a urethra, the catheter having an outer surface, a first end, a second end, a first circumferential portion for orientation toward a first portion of a wall of the urethra, and a second circumferential portion for orientation toward a second portion of the wall of the urethra opposite the first portion of the wall of the urethra; radiation means within the catheter for producing an emission capable of necrosing target prostate tissue spaced from a surface of the wall of the urethra; first means within the catheter disposed between the radiating means and the outer surface of the catheter at both the first and second circumferential portions for preventing necrosis of the surface of the wall of the urethra; and a balloon connected to the outer surface of the catheter adjacent the radiation means, the balloon defining a chamber partially surrounding the radiation means on the second circumferential portion of the catheter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-31 | 2002-03-02 | 2002-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-31 | 2006-03-02 | 2006-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-31 | 2010-03-02 | 2010-09-01 | $7700.00 | Window Closed / Lapsed |