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US5330518A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for treating interstitial tissue associated with microwave thermal therapy

Assignee: Auslo Research LLC
•
Filing: 1992-03-06
•
Granted: 1994-07-19
•
Expires: 2012-03-06
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Abstract

Abstract A method of selectively treating interstitial tissue following microwave thermal therapy includes an intraurethral Foley-type catheter shaft. The catheter shaft contains a microwave antenna which is capable of generating a cylindrically symmetrical thermal pattern in tissue, within which temperatures are capable of exceeding 45° C. The antenna is surrounded by means within the shaft for asymmetrically absorbing electromagnetic energy emitted by the antenna so as to concentrate thermal energy on a first side of the shaft. This asymmetrical absorption alters the thermal pattern generated by the microwave antenna, making it possible to focus microwave thermal therapy toward undesirous tissue and away from healthy tissue. The absorption means is also capable of absorbing heat from adjacent tissue by thermal conduction. Operation of the absorption means upon the conclusion of microwave thermal therapy aids in reducing edema of the treated tissues caused by the elevated temperatures of those tissues.

Inventors

  • 👤 Bruce H. Neilson
  • 👤 Eric N. Rudie
  • 👤 Mitchell Dann

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 12:34
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/1815; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00057; A61B2017/00084; A61B17/00234; A61B2017/00238; A61B2017/00274; A61B2017/00292; A61B17/22; A61B2017/22051; A61B2017/22065; A61B2017/22069; A61B2018/00005; A61B2018/00011; A61B2018/00315; A61B2018/00547

Claims Analysis

Total Claims: 17
Claim 1
Independent Claim 146 words
A method for treating benign prostatic hyperplasia comprising: inserting a microwave antenna-containing catheter shaft into a urethra so as to position the microwave antenna adjacent a prostatic region of the urethra, the catheter shaft having a first lumen and a second lumen, the first and second lumens circumjacent the microwave antenna; providing a drive signal the antenna to apply an RF emission to tissue surrounding the urethra, the RF emission causing molecular excitation of tissue surrounding the urethra sufficient to heat the tissue; circulating a fluid through the first lumen and the second lumen while providing the drive signal to absorb energy emitted by the antenna and heat conducted by tissue adjacent an outer surface of the shaft; and continuing to circulate the fluid through the first lumen and second lumen for a period of at least about 10 minutes after the drive signal is terminated.
Claim 2
Independent Claim 146 words
A method for treating benign prostatic hyperplasia comprising: inserting a microwave antenna-containing catheter shaft into a urethra so as to position the microwave antenna adjacent a prostatic region of the urethra, the catheter shaft having a first lumen and a second lumen, the first and second lumens circumjacent the microwave antenna; providing a drive signal the antenna to apply an RF emission to tissue surrounding the urethra, the RF emission causing molecular excitation of tissue surrounding the urethra sufficient to heat the tissue; circulating a fluid through the first lumen and the second lumen while providing the drive signal to absorb energy emitted by the antenna and heat conducted by tissue adjacent an outer surface of the shaft; and continuing to circulate the fluid through the first lumen and second lumen for a period of at least about 10 minutes after the drive signal is terminated.
Claim 3
Dependent Claim 47 words
The method of claim 1 wherein the step of circulating the fluid through the first and second lumens while providing the drive signal to the antenna causes at least some of the tissue of the prostate to be heated to a temperature of above about 45° C.
Claim 4
Dependent Claim 31 words
The method of claim 1 wherein the fluid continues to be circulated through the first and second lumens for about 10 to about 120 minutes following termination of the drive signal.
Claim 5
Independent Claim 94 words
A method for treating interstitial tissues associated with an application of thermal energy comprising: inserting into a body cavity a catheter which contains heating means for heating a volume of tissue surrounding the catheter, and cooling means within the catheter, circumjacent an exterior surface of the catheter for absorbing thermal energy from tissue immediately adjacent the catheter; activating the heating means; activating the cooling means during operation of the heating means; deactivating the heating means; and continuing to operate the cooling means, following deactivation of the heating means, for at least about 10 minutes.
Claim 6
Independent Claim 94 words
A method for treating interstitial tissues associated with an application of thermal energy comprising: inserting into a body cavity a catheter which contains heating means for heating a volume of tissue surrounding the catheter, and cooling means within the catheter, circumjacent an exterior surface of the catheter for absorbing thermal energy from tissue immediately adjacent the catheter; activating the heating means; activating the cooling means during operation of the heating means; deactivating the heating means; and continuing to operate the cooling means, following deactivation of the heating means, for at least about 10 minutes.
Claim 7
Dependent Claim 39 words
The method of claim 4 wherein the steps of activating the heating means and activating the cooling means while the heating means is activated cause at least some tissue to be heated to a temperature above about 45° C.
Claim 8
Dependent Claim 25 words
The method of claim 4 wherein the cooling means continues to operate for about 10 to about 120 minutes following deactivation of the heating means.
Claim 9
Independent Claim 124 words
A method for treating benign prostatic hyperplasia comprising: inserting a microwave antenna-containing catheter into a urethra so as to position the microwave antenna adjacent a prostatic region of the urethra, the catheter having a urine drainage lumen and coolant circulation lumens; providing a drive signal to the antenna to cause heating of prostatic tissue surrounding the urethra; circulating a coolant through the coolant circulation lumens while providing the drive signal to cool the urethra while the prostatic tissue is being heated; and leaving the catheter in place within the urethra after heating of the prostatic tissue is terminated while continuing to circulate the coolant through the coolant circulation lumens for a period of at least about 10 minutes after heating of the prostatic tissue.
Claim 10
Independent Claim 124 words
A method for treating benign prostatic hyperplasia comprising: inserting a microwave antenna-containing catheter into a urethra so as to position the microwave antenna adjacent a prostatic region of the urethra, the catheter having a urine drainage lumen and coolant circulation lumens; providing a drive signal to the antenna to cause heating of prostatic tissue surrounding the urethra; circulating a coolant through the coolant circulation lumens while providing the drive signal to cool the urethra while the prostatic tissue is being heated; and leaving the catheter in place within the urethra after heating of the prostatic tissue is terminated while continuing to circulate the coolant through the coolant circulation lumens for a period of at least about 10 minutes after heating of the prostatic tissue.
Claim 11
Dependent Claim 27 words
The method of claim 7 wherein the period during which coolant continues to be circulated after heating is terminated is between about 10 to about 120 minutes.
Claim 12
Independent Claim 97 words
A method for treating interstitial tissues associated with an application of thermal energy comprising: inserting into a body cavity a catheter which contains heating means for heating a volume of tissue surrounding the catheter, and cooling means for cooling tissue immediately adjacent the catheter; activating the heating means during a first time period; activating the cooling means during the first time period; and leaving the catheter in place in the body cavity after the first time period has ended while continuing to operate the cooling means for a second time period of at least about 10 minutes.
Claim 13
Independent Claim 97 words
A method for treating interstitial tissues associated with an application of thermal energy comprising: inserting into a body cavity a catheter which contains heating means for heating a volume of tissue surrounding the catheter, and cooling means for cooling tissue immediately adjacent the catheter; activating the heating means during a first time period; activating the cooling means during the first time period; and leaving the catheter in place in the body cavity after the first time period has ended while continuing to operate the cooling means for a second time period of at least about 10 minutes.
Claim 14
Dependent Claim 20 words
The method of claim 9 wherein the second time period has a duration of about 10 to about 120 minutes.
Claim 15
Independent Claim 84 words
A method of treating peri-urethral tumorous tissue of a prostate, the method comprising: inserting a catheter having a plurality of lumens within a urethra with a proximal region of the catheter adjacent the prostate; applying heat from the catheter to the prostate sufficient to necrose at least some of the tumorous tissue of the prostate; and circulating a fluid within the plurality of lumens of the catheter following the step of applying heat so as to minimize swelling of prostatic tissue surrounding the urethra.
Claim 16
Independent Claim 84 words
A method of treating peri-urethral tumorous tissue of a prostate, the method comprising: inserting a catheter having a plurality of lumens within a urethra with a proximal region of the catheter adjacent the prostate; applying heat from the catheter to the prostate sufficient to necrose at least some of the tumorous tissue of the prostate; and circulating a fluid within the plurality of lumens of the catheter following the step of applying heat so as to minimize swelling of prostatic tissue surrounding the urethra.
Claim 17
Dependent Claim 24 words
The method of claim 11 wherein the fluid is circulated between about 10 minutes and about 120 minutes following the step of applying heat.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1997-07-18 1998-01-17 1998-07-19 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2001-07-18 2002-01-17 2002-07-19 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2005-07-18 2006-01-17 2006-07-19 $7700.00 Window Closed / Lapsed

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