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US5798267A
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Method for determining alcohol consumption rates
Assignee: ALCOHOL DETECTION SERVICES LLC
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Filing: 1995-06-07
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Granted: 1998-08-25
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Expires: 2015-06-07
Abstract
Abstract A method for assessing or determining alcohol consumption rates including using a blood specimen from a human subject to develop an individual blood constituent panel; comparing the individual panel with a reference blood constituent panel to provide categories corresponding to rates of alcohol consumption; and identifying the category of consumption rate. The methods of the invention can be varied through modification of one of several statistical models used therewith to preferentially weigh the analysis and identify one consumption category over another. Multi-variate and similar such statistical techniques correlate comparisons of individual/subject blood and reference panel constituents with recognized consumptions rates.
Inventors
- 👤 James W. Harasymiw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:37
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N33/72; G16; G16H; G16H10/00; G16H10/40; G01N2496/00; G01N2496/80; G16H10/20; Y; Y10; Y10T; Y10T436/00; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444; Y10T436/145555; Y10T436/146666; Y10T436/147777; Y10T436/148888; Y10T436/17; Y10T436/171538; Y10T436/20; Y10T436/203332; Y10T436/204165
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
96 words
A method of initially assessing alcohol consumption rates, comprising: using a blood specimen from a human subject to develop an individual blood constituent panel, said panel having at least ten constituents including a ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; comparing said individual panel with a reference blood constituent panel to provide categories corresponding to rates of alcohol consumption, said blood reference panel including the ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; and identifying the category of consumption rate for said subject indicated by said comparison.
Claim 2
Independent Claim
96 words
A method of initially assessing alcohol consumption rates, comprising: using a blood specimen from a human subject to develop an individual blood constituent panel, said panel having at least ten constituents including a ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; comparing said individual panel with a reference blood constituent panel to provide categories corresponding to rates of alcohol consumption, said blood reference panel including the ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; and identifying the category of consumption rate for said subject indicated by said comparison.
Claim 3
Dependent Claim
34 words
The method as defined in claim 1 wherein said reference blood constituent panel includes value ranges for the level of each said constituent, whereby the relationship of one constituent to another can be determined.
Claim 4
Dependent Claim
40 words
The method as defined in claim 1 wherein said reference panel is developed using a pool of human subjects and prior probability values corresponding to the likelihood that said subject would be classified in a particular category of alcohol consumption.
Claim 5
Dependent Claim
24 words
The method as defined in claim 3 wherein there are a plurality of alcohol consumption categories, said categories corresponding to increasing alcohol consumption rates.
Claim 6
Dependent Claim
15 words
The method as defined in claim 4 wherein there are three categories of alcohol consumption.
Claim 7
Dependent Claim
42 words
The method as defined in claim 5 wherein: a probability value of about 0.7-0.9 represents the lowest consumption rate; a probability value of about 0.08-0.20 represents the intermediate consumption rate; and a probability value of about 0.01-0.10 represents the highest consumption rate.
Claim 8
Dependent Claim
37 words
The method as defined in claim 6 wherein the highest consumption rate is associated with the ratio of direct bilirubin concentration to total bilirubin concentration, said ratio a constituent of said individual and reference blood constituent panels.
Claim 9
Dependent Claim
17 words
The method as defined in claim 4 wherein said categories are derived from alcohol assessment standard instruments.
Claim 10
Dependent Claim
29 words
The method as defined in claim 8 wherein said instruments are selected from the group of psychological tests consisting of the Khavari Alcohol Test, the McAndrew Scale, and MODCRIT.
Claim 11
Dependent Claim
16 words
The method as defined in claim 8 wherein said instruments are volume frequency alcoholism assessment tests.
Claim 12
Dependent Claim
29 words
The method as defined in claim 10 wherein said instruments are selected from the group of psychological tests consisting of the Khavari Alcohol Test, the McAndrew Scale, and MODCRIT.
Claim 13
Dependent Claim
28 words
The method as defined in claim 1 wherein said comparison further includes use of a statistical analysis modifiable to preferentially identity one category of consumption rate over another.
Claim 14
Dependent Claim
15 words
The method as defined in claim 12 wherein said analysis is a multi-variate statistical technique.
Claim 15
Dependent Claim
14 words
The method as defined in claim 13 wherein said individual constituent panel is standardized.
Claim 16
Dependent Claim
27 words
The method as defined in claim 13 wherein said technique is selected from the group consisting of logistic regression, discriminant analysis, cluster analysis, factor analysis, and neuronetworking.
Claim 17
Dependent Claim
37 words
The method as defined in claim 12 wherein said statistical analysis incorporates factors selected from the group consisting of age, gender, race, nationality, diet, geography, socioeconomic status and drug interaction to increase the accuracy of said identification.
Claim 18
Dependent Claim
34 words
The method as defined in claim 1 further including a second comparison of said individual panel with said reference panel having an additional constituent such that said identification is made without false positive results.
Claim 19
Dependent Claim
27 words
The method as defined in claim 17 wherein said additional constituents are selected from the group consisting of selenium, β-hexacosanamine, carbohydrate deficient transferrin, and hemoglobin associated acetaldehyde.
Claim 20
Independent Claim
128 words
A method of identifying individuals having a high alcohol consumption rate , said method comprising: using a blood specimen from said subject to develop a subject blood constituent panel, said panel having at least ten constituents including a ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; comparing said subject panel with a first reference blood constituent panel, said reference panel including the ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; identifying the category of consumption rate for said subject indicated by said comparison; and minimizing false positive results with a second reference blood constituent panel as a reflex test off said first reference panel, said second reference panel including an additional constituent, said additional constituent being a blood alcohol marker.
Claim 21
Independent Claim
128 words
A method of identifying individuals having a high alcohol consumption rate , said method comprising: using a blood specimen from said subject to develop a subject blood constituent panel, said panel having at least ten constituents including a ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; comparing said subject panel with a first reference blood constituent panel, said reference panel including the ratio of direct bilirubin concentration to total bilirubin concentration as a constituent; identifying the category of consumption rate for said subject indicated by said comparison; and minimizing false positive results with a second reference blood constituent panel as a reflex test off said first reference panel, said second reference panel including an additional constituent, said additional constituent being a blood alcohol marker.
Claim 22
Dependent Claim
35 words
The method as defined in claim 19 wherein said reference blood constituent panel includes value ranges corresponding to the level of each said constituent, whereby the relationship of one constituent to another can be determined.
Claim 23
Dependent Claim
18 words
The method as defined in claim 20 wherein said subject panel constituent values are converted to standard scores.
Claim 24
Dependent Claim
40 words
The method as defined in claim 20 wherein said reference panel is developed using a pool of human subjects and prior probability values corresponding to the likelihood that said subject would be classified in a particular category of alcohol consumption.
Claim 25
Dependent Claim
24 words
The method as defined in claim 22 wherein there are a plurality of alcohol consumption categories, said categories corresponding to increasing alcohol consumption rates.
Claim 26
Dependent Claim
65 words
The method as defined in claim 23 wherein there are three categories of alcohol consumption, said categories corresponding to increasing consumption rates of alcohol per unit time, and where such prior probability values are: about 0.70-0.90 for that category reflecting the lowest consumption rate; about 0.08-0.20 for that category reflecting the intermediate consumption rate; and about 0.01-0.10 for that category reflecting the highest consumption rate.
Claim 27
Dependent Claim
17 words
The method as defined in claim 22 wherein said categories are derived from alcohol assessment standard instruments.
Claim 28
Dependent Claim
16 words
The method as defined in claim 25 wherein said instruments are volume frequency alcoholism assessment tests.
Claim 29
Dependent Claim
26 words
The method as defined in claim 26 wherein said instruments are selected from the group consisting of the Khavari Alcohol Test, the McAndrew Scale, and MODCRIT.
Claim 30
Dependent Claim
28 words
The method as defined in claim 19 wherein said comparison further includes use of a statistical analysis modifiable to preferentially identify one category of consumption rate over another.
Claim 31
Dependent Claim
15 words
The method as defined in claim 28 wherein said analysis is a multi-variate statistical technique.
Claim 32
Dependent Claim
28 words
The method as defined in claim 29 wherein said technique is selected from the group consisting of logistic regression, discriminant analysis, cluster analysis, factor analysis, and neuron networking.
Claim 33
Dependent Claim
37 words
The method as defined in claim 28 wherein said statistical analysis incorporates factors selected from the group consisting of age, gender, race, nationality, diet, geography, socioeconomic status and drug interaction to increase the accuracy of said identification.
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