US5795922A
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US
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Bone cement composistion containing microencapsulated radiopacifier and method of making same
Assignee: Clemson University
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Filing: 1995-06-06
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Granted: 1998-08-18
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Expires: 2015-06-06
Abstract
Abstract A radiopaque bone cement used to repair bone or other hard tissues is provided. The bone cement is made from combining a composition containing an acrylic powder and a radiopacifier with a corresponding liquid monomer. Prior to being added to the composition, the radiopacifier is microencapsulated with a bone cement compatible material. When combined with the liquid monomer, the bone cement compatible material dissolves releasing the radiopacifier particles into a bone cement matrix. By being microencapsulated, the radiopacifier is prevented from agglomerating in the cement. Instead, the radiopacifier particles become dispersed throughout the bone cement matrix which not only creates a radiopaque cement but also increases the fatigue life of the cement.
Inventors
- 👤 Hany W. Demian
- 👤 Shalaby W. Shalaby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:28
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/04; A61L24/06; A61L2430/00; A61L2430/02; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
122 words
A radiopaque composition for combining with a liquid monomer to produce a bone cement, said composition comprising: an acrylic powder capable of polymerizing and ultimately hardening when combined with a corresponding liquid monomer; and a predetermined amount of hollow microspheres, said hollow microspheres comprising a spherical wall made from a bone cement compatible polymer that dissolves in said liquid monomer, said hollow microspheres further including a radiopacifier contained within said spherical wall, said radiopacifier comprising an inorganic compound and wherein, when said hollow microspheres are combined with a liquid monomer, said bone cement compatible polymer dissolves dispersing said radiopacifier throughout a bone cement matrix, said predetermined amount of hollow microspheres being sufficient to make a bone cement made with said composition radiopaque.
Claim 2
Dependent Claim
122 words
A radiopaque composition for combining with a liquid monomer to produce a bone cement, said composition comprising: an acrylic powder capable of polymerizing and ultimately hardening when combined with a corresponding liquid monomer; and a predetermined amount of hollow microspheres, said hollow microspheres comprising a spherical wall made from a bone cement compatible polymer that dissolves in said liquid monomer, said hollow microspheres further including a radiopacifier contained within said spherical wall, said radiopacifier comprising an inorganic compound and wherein, when said hollow microspheres are combined with a liquid monomer, said bone cement compatible polymer dissolves dispersing said radiopacifier throughout a bone cement matrix, said predetermined amount of hollow microspheres being sufficient to make a bone cement made with said composition radiopaque.
Claim 3
Dependent Claim
26 words
A composition as defined in claim 1, wherein said radiopacifier is a material selected from the group consisting of metal oxides, barium salts, and bismuth glass.
Claim 4
Dependent Claim
13 words
A composition as defined in claim 1, wherein said radiopacifier comprises barium sulfate.
Claim 5
Dependent Claim
27 words
A composition as defined in claim 1, wherein said bone cement compatible polymer is a material selected from the group consisting of polymethyl methacrylate and copolymers thereof.
Claim 6
Dependent Claim
22 words
A composition as defined in claim 1, wherein said hollow microspheres have a size between about 1 micron to about 250 microns.
Claim 7
Dependent Claim
28 words
A composition as defined in claim 1, wherein said radiopacifier is present within each microsphere in an amount from about 15 percent to about 70 percent by weight.
Claim 8
Dependent Claim
32 words
A composition as defined in claim 4, wherein said bone cement compatible polymer has a weight average molecular weight between from about 30,000 to about 500,000 as determined by gel permeation chromatography.
Claim 9
Dependent Claim
28 words
A composition as defined in claim 1, wherein said radiopacifier is present within said composition in an amount from about 5 percent to about 30 percent by weight.
Claim 10
Dependent Claim
12 words
A composition as defined in claim 1, further comprising a polymerization initiator.
Claim 11
Dependent Claim
14 words
A composition as defined in claim 9, wherein said polymerization initiator comprises benzoyl peroxide.
Claim 12
Dependent Claim
19 words
A composition as defined in claim 1, wherein said spherical wall is from 1 micron to 25 microns thick.
Claim 13
Dependent Claim
149 words
An improved composition used in making a bone cement, said composition including an acrylic powder and a polymerization initiator, wherein, when said composition is mixed with a solution containing a corresponding liquid monomer, said acrylic powder polymerizes and hardens forming a resulting cement used in repairing or replacing bones and other hard tissues, said improvement comprising: a predetermined amount of hollow microspheres added to said acrylic powder, each of said hollow microspheres comprising a thin spherical coating of a bone cement compatible material said spherical coating containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when said improved composition is combined with a corresponding liquid monomer, a predominant portion of said coating of said bone cement compatible material dissolves releasing and disbursing said radiopacifier throughout a curing bone cement matrix, said radiopacifier for creating a radiopaque bone cement and for increasing the fatigue life of said cement.
Claim 14
Dependent Claim
149 words
An improved composition used in making a bone cement, said composition including an acrylic powder and a polymerization initiator, wherein, when said composition is mixed with a solution containing a corresponding liquid monomer, said acrylic powder polymerizes and hardens forming a resulting cement used in repairing or replacing bones and other hard tissues, said improvement comprising: a predetermined amount of hollow microspheres added to said acrylic powder, each of said hollow microspheres comprising a thin spherical coating of a bone cement compatible material said spherical coating containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when said improved composition is combined with a corresponding liquid monomer, a predominant portion of said coating of said bone cement compatible material dissolves releasing and disbursing said radiopacifier throughout a curing bone cement matrix, said radiopacifier for creating a radiopaque bone cement and for increasing the fatigue life of said cement.
Claim 15
Dependent Claim
21 words
An improved composition as defined in claim 12, wherein said radiopacifier is a barium salt, zirconium dioxide, or a bismuth glass.
Claim 16
Dependent Claim
42 words
An improved composition as defined in claim 12, wherein said coating of bone cement compatible material is comprised of a material selected from the group consisting of polymethyl methacrylate and copolymers thereof, said coating being between 1 micron and 10 microns thick.
Claim 17
Dependent Claim
23 words
An improved composition as defined in claim 12, wherein said hollow microspheres have a size between about 5 microns to about 100 microns.
Claim 18
Dependent Claim
26 words
An improved composition as defined in claim 12, wherein said radiopacifier comprises from about 15 percent to about 70 percent by weight of each hollow microsphere.
Claim 19
Dependent Claim
28 words
An improved composition as defined in claim 12, wherein said radiopacifier is present within said composition in an amount from about 5 percent to 30 percent by weight.
Claim 20
Dependent Claim
191 words
An improved composition used in making a bone cement, said composition including an acrylic powder and a polymerization initiator, wherein, when said composition is mixed with a solution containing a corresponding liquid monomer, said acrylic powder polymerizes and hardens forming a resulting cement used in repairing or replacing bones and other hard tissues, said improvement comprising: a predetermined amount of hollow microspheres added to said acrylic powder, each of said hollow microspheres comprising a thin spherical coating of a bone cement compatible material, said spherical coating containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when said improved composition is combined with a corresponding liquid monomer, a predominant portion of said coating of said bone cement compatible material dissolves releasing and dispersing said radiopacifier throughout a curing bone cement matrix, and wherein said coating of said bone cement compatible material has a thickness such that said coating will completely dissolve when 40 grams of said composition are combined with 20 ml of a liquid monomer and mixed for at least 2 minutes, said radiopacifier for creating a radiopaque bone cement and for increasing the fatigue life of said cement.
Claim 21
Dependent Claim
191 words
An improved composition used in making a bone cement, said composition including an acrylic powder and a polymerization initiator, wherein, when said composition is mixed with a solution containing a corresponding liquid monomer, said acrylic powder polymerizes and hardens forming a resulting cement used in repairing or replacing bones and other hard tissues, said improvement comprising: a predetermined amount of hollow microspheres added to said acrylic powder, each of said hollow microspheres comprising a thin spherical coating of a bone cement compatible material, said spherical coating containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when said improved composition is combined with a corresponding liquid monomer, a predominant portion of said coating of said bone cement compatible material dissolves releasing and dispersing said radiopacifier throughout a curing bone cement matrix, and wherein said coating of said bone cement compatible material has a thickness such that said coating will completely dissolve when 40 grams of said composition are combined with 20 ml of a liquid monomer and mixed for at least 2 minutes, said radiopacifier for creating a radiopaque bone cement and for increasing the fatigue life of said cement.
Claim 22
Independent Claim
120 words
A method of dispersing a radiopacifier within a bone cement, said method comprising the steps of: microencapsulating a radiopacifier with a wall forming polymer to form hollow radiopaque microspheres, said hollow microspheres having a spherical wall made from said wall forming polymer, said radiopacifier being contained within said spherical wall, said radiopacifier comprising an inorganic compound, said wall forming polymer being bone cement compatible; combining said hollow microspheres with an acrylic powder, said hollow microspheres being added to said acrylic powder in an amount sufficient to make a resulting bone cement radiopaque; and contacting said hollow microspheres and said acrylic powder with a liquid monomer causing said wall forming polymer to dissolve releasing said radiopacifier into a bone cement matrix.
Claim 23
Independent Claim
120 words
A method of dispersing a radiopacifier within a bone cement, said method comprising the steps of: microencapsulating a radiopacifier with a wall forming polymer to form hollow radiopaque microspheres, said hollow microspheres having a spherical wall made from said wall forming polymer, said radiopacifier being contained within said spherical wall, said radiopacifier comprising an inorganic compound, said wall forming polymer being bone cement compatible; combining said hollow microspheres with an acrylic powder, said hollow microspheres being added to said acrylic powder in an amount sufficient to make a resulting bone cement radiopaque; and contacting said hollow microspheres and said acrylic powder with a liquid monomer causing said wall forming polymer to dissolve releasing said radiopacifier into a bone cement matrix.
Claim 24
Independent Claim
200 words
A method of dispersing a radiopacifier within a bone cement, said method comprising the steps of: coating a radiopacifier with a wall forming polymer to form hollow radiopaque microspheres, said hollow microspheres having a spherical wall made from said wall forming polymer, said radiopacifier being contained within said spherical wall, said radiopacifier comprising an inorganic compound, said wall forming polymer being bone cement compatible; combining said hollow microspheres with an acrylic powder, said hollow microspheres being added to said acrylic powder in an amount sufficient to make a resulting bone cement radiopaque; and contacting said hollow microspheres and said acrylic powder with a liquid monomer causing said coating of wall forming polymer to dissolve releasing said radiopacifier into a bone cement matrix, and wherein the method of coating said radiopacifier comprises the steps of: combining said wall forming polymer and said radiopacifier with a solvent, wherein said wall forming polymer dissolves in said solvent; blending said solvent containing said polymer and said radiopacifier with an aqueous solution to form an emulsion, said solvent being immiscible within said aqueous solution; evaporating said solvent from said emulsion thereby forming said hollow microspheres; and separating said hollow microspheres from said remaining aqueous solution.
Claim 25
Independent Claim
200 words
A method of dispersing a radiopacifier within a bone cement, said method comprising the steps of: coating a radiopacifier with a wall forming polymer to form hollow radiopaque microspheres, said hollow microspheres having a spherical wall made from said wall forming polymer, said radiopacifier being contained within said spherical wall, said radiopacifier comprising an inorganic compound, said wall forming polymer being bone cement compatible; combining said hollow microspheres with an acrylic powder, said hollow microspheres being added to said acrylic powder in an amount sufficient to make a resulting bone cement radiopaque; and contacting said hollow microspheres and said acrylic powder with a liquid monomer causing said coating of wall forming polymer to dissolve releasing said radiopacifier into a bone cement matrix, and wherein the method of coating said radiopacifier comprises the steps of: combining said wall forming polymer and said radiopacifier with a solvent, wherein said wall forming polymer dissolves in said solvent; blending said solvent containing said polymer and said radiopacifier with an aqueous solution to form an emulsion, said solvent being immiscible within said aqueous solution; evaporating said solvent from said emulsion thereby forming said hollow microspheres; and separating said hollow microspheres from said remaining aqueous solution.
Claim 26
Dependent Claim
22 words
A method as defined in claim 19, wherein said radiopacifier is a barium salt, a metal oxide, bismuth glass, or mixtures thereof.
Claim 27
Dependent Claim
26 words
A method as defined in claim 19, wherein said wall forming polymer is a material selected from the group consisting of polymethyl methacrylate and copolymers thereof.
Claim 28
Dependent Claim
18 words
A method as defined in claim 20, further comprising the step of adding an emulsifier to said emulsion.
Claim 29
Dependent Claim
26 words
A method as defined in claim 20, wherein said solvent is a material selected from the group consisting of methylene chloride, chloroform, ethylene chloride and benzene.
Claim 30
Dependent Claim
96 words
A bone cement system for producing a radiopaque bone cement, said system comprising: a liquid monomer; and a corresponding dry component composition for combining with said monomer to form a cement, said composition comprising an acrylic powder mixed with hollow microspheres, said hollow microspheres comprising a spherical wall made from a bone cement compatible polymer, said spherical wall containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when combined with said monomer, said bone cement compatible polymer dissolves dispersing said radiopacifier throughout said resulting cement in an amount sufficient to make said cement radiopaque.
Claim 31
Dependent Claim
96 words
A bone cement system for producing a radiopaque bone cement, said system comprising: a liquid monomer; and a corresponding dry component composition for combining with said monomer to form a cement, said composition comprising an acrylic powder mixed with hollow microspheres, said hollow microspheres comprising a spherical wall made from a bone cement compatible polymer, said spherical wall containing a radiopacifier therein, said radiopacifier comprising an inorganic compound, wherein, when combined with said monomer, said bone cement compatible polymer dissolves dispersing said radiopacifier throughout said resulting cement in an amount sufficient to make said cement radiopaque.
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