Process for preparing stabilized chitin derivative compounds

Claim 2

A process for preparing a sterilized polysaccharide composition, said composition comprising a polysaccharide selected from the group consisting of N-alkyl chitosan, 6-O-alkyloxy chitosan, N,O-alkyl chitosan, N,N-dialkyl chitosan, N-halochitosan, O-carboxymethyl chitosan N,O-carboxymethyl chitosan, N-carboxymethyl chitosan, N,O-sulfur chitosan, 1 -deoxygalactit-1-yl-chitosan, 1-deoxygalucite-1-yl-chitosan, N,O-ethylamine chitosan and mixtures thereof, which process comprises the steps of: a) forming a suspension of said polysaccharide in a solvent, said polysaccharide being substantially insoluble in said solvent; b) sterilizing said suspension, thereby forming a sterilized suspension; and c) thereafter, solubilizing said polysaccharide, thereby forming a sterilized polysaccharide solution.

Claim 3

The process of claim 1 wherein said solvent is water.

Claim 4

The process of claim 1 wherein said suspension is thermally sterilized.

Claim 5

The process of claim 1 wherein said sterilized suspension of said polysaccharide is solubilized by adding an aseptic acid.

Claim 6

The process of claim 1 wherein said polysaccharide is chitosan, said suspension is sterilized in an autoclave and said sterilized suspension of said polysaccharide is solubilized by adding an aseptic acid.

Claim 7

A process for preparing a sterilized polysaccharide composition, said composition comprising a water-soluble polysaccharide selected from chitosan derivatives, chitin derivatives and mixtures thereof, which process comprises the steps of: a) forming a solution of said polysaccharide in an aqueous solvent, said polysaccharide being substantially soluble in said solvent, b) changing the pH of said solution to form a basic solution, c) sterilizing said basic solution, thereby forming a sterilized polysaccharide solution, and d) titrating said sterilized polysaccharide solution with an aseptic acid to a desired pH, wherein said chitosan derivatives are selected from the group consisting of chitosan polymers having one or more hydrophilic substitutents at 2-N and/or 6O positions said hydrophilic substitutents being selected from the group consisting of carboxyalkyl hydroxyalkyl, sulfuryl, phosphoryl and amino, and said chitin derivatives are selected from the group consisting of N,O-ethylamine chitin and O-sulfur chitin.

Claim 8

A process for preparing a sterilized polysaccharide composition, said composition comprising a water-soluble polysaccharide selected from chitosan derivatives, chitin derivatives and mixtures thereof, which process comprises the steps of: a) forming a solution of said polysaccharide in an aqueous solvent, said polysaccharide being substantially soluble in said solvent, b) changing the pH of said solution to form a basic solution, c) sterilizing said basic solution, thereby forming a sterilized polysaccharide solution, and d) titrating said sterilized polysaccharide solution with an aseptic acid to a desired pH, wherein said chitosan derivatives are selected from the group consisting of chitosan polymers having one or more hydrophilic substitutents at 2-N and/or 6O positions said hydrophilic substitutents being selected from the group consisting of carboxyalkyl hydroxyalkyl, sulfuryl, phosphoryl and amino, and said chitin derivatives are selected from the group consisting of N,O-ethylamine chitin and O-sulfur chitin.

Claim 9

The process of claim 6 wherein said composition further comprises a polyol having a 1, 2-diol hydrocarbon moiety.

Claim 10

The process of claim 6 wherein said solvent is water.

Claim 11

The process of claim 6 wherein said basic solution has a pH equal to or higher than about 8 and is formed by adding a base or an alkaline material.

Claim 12

The process of claim 6 wherein said solution is thermally sterilized.

Claim 13

The process of claim 7 wherein said solution is sterilized in an autoclave.

Claim 14

A process for producing a stabilized, sterilized polysaccharide solution composition comprising a polysaccharide selected from the group consisting of chitosan, chitosan derivatives, chitin derivatives and mixtures thereof, which process comprises the step of adding to said solution composition a polyol having a 1, 2-diol hydrocarbon moiety before said solution composition is subjected to a sterilizing process, wherein said sterilizing process has a degradation effect on said solution composition and said polyol diminishes said, degradation effect, wherein said chitosan derivatives are selected from the group consisting of N-alkyl chitosan, 6-O-alkyloxy chitosan, N,O-alkyl chitosan N,N-dialkyl chitosan, N-halochitosan, and chitosan polymers having one or more hydrophilic substitutents at 2-N and/or 6-O positions, said hydrophilic substitutents being selected from the group consisting of carboxyalkyl hydroxyalkyl, sulfuryl, phosphoryl and amino, and said chitin derivatives are selected from the group consisting of N,O-ethylamine chitin and O-sulfur chitin.

Claim 15

A process for producing a stabilized, sterilized polysaccharide solution composition comprising a polysaccharide selected from the group consisting of chitosan, chitosan derivatives, chitin derivatives and mixtures thereof, which process comprises the step of adding to said solution composition a polyol having a 1, 2-diol hydrocarbon moiety before said solution composition is subjected to a sterilizing process, wherein said sterilizing process has a degradation effect on said solution composition and said polyol diminishes said, degradation effect, wherein said chitosan derivatives are selected from the group consisting of N-alkyl chitosan, 6-O-alkyloxy chitosan, N,O-alkyl chitosan N,N-dialkyl chitosan, N-halochitosan, and chitosan polymers having one or more hydrophilic substitutents at 2-N and/or 6-O positions, said hydrophilic substitutents being selected from the group consisting of carboxyalkyl hydroxyalkyl, sulfuryl, phosphoryl and amino, and said chitin derivatives are selected from the group consisting of N,O-ethylamine chitin and O-sulfur chitin.

Claim 16

The process of claim 12 wherein said polyol is selected from the group consisting of alditols, glycols and saccharides.

Claim 17

The process of claim 13 wherein said polyol is selected from the group consisting of mannitol and sorbitol.

Claim 18

The process of claim 14 wherein said polysaccharide composition has between about 0.5 wt % and about 20 wt %, based on the total weight of the composition, of said polyol.