EP0426368A2
Expired / Lapsed
EP
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Compositions containing derivatives of chitin for preventing adhesion
Assignee: MTG Divestitures LLC
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Filing: 1990-10-24
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Granted: —
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Expires: 2010-10-24
Abstract
Abstract The invention comprises polymer compositions containing cross-linked biodegradable derivatives of chitin for use in preventing adhesion between body tissues.
Inventors
- 👤 Paul A. Higham
- 👤 Jessica D. Posey-Dowty
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 18:17
CPC Classifications
A; A61; A61L; A61L17/00; C; C08; C08J; C08J5/00; C08J5/18; A61L31/00; A61L31/04; A61L31/042; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003; C08J2305/00; C08J2305/08
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
62 words
A polymer composition preparable by the steps of: (a) dissolving at least one biodegradable derivative of chitin in a dilute acidic aqueous solution; (b) drying the solution to form a film; (c) cross-linking the film by wetting it with an aqueous solution containing a cross-linking agent; and (d) forming a visco-elastic fluid therefrom by dissolving the film in a hot aqueous solution.
Claim 2
Dependent Claim
62 words
A polymer composition preparable by the steps of: (a) dissolving at least one biodegradable derivative of chitin in a dilute acidic aqueous solution; (b) drying the solution to form a film; (c) cross-linking the film by wetting it with an aqueous solution containing a cross-linking agent; and (d) forming a visco-elastic fluid therefrom by dissolving the film in a hot aqueous solution.
Claim 3
Dependent Claim
32 words
A composition as claimed in claim 1 wherein in part (a) said biodegradable derivative of chitin is selected from N,0 CM-chitosan, chitosan, CM-chitosan, N, CM-chitosan O, CM-chitosan sulfated N, CM-chitosan and CM-chitin.
Claim 4
Dependent Claim
32 words
A composition as claimed in claim 1 or 2 wherein in part (a) the amount of said at least one biodegradable derivative of chitin used is a maximum of 4% by weight.
Claim 5
Dependent Claim
23 words
A composition as claimed in any preceding claim wherein in part (a) an anti-thrombogenic agent is also added to the acidic aqueous solution.
Claim 6
Dependent Claim
22 words
A composition as claimed in any preceding claim wherein in part (a) the dilute acidic aqueous solution is dilute aqueous acetic acid.
Claim 7
Dependent Claim
27 words
A composition as claimed in any preceding claim wherein in part (c) the cross-linking agent is sulphuric acid in a solution concentration of 0.5 molar or less.
Claim 8
Dependent Claim
38 words
A composition as claimed in any one of claims 1 to 5 wherein in part (c) the cross-linking agent is selected from aspartic acid or a salt thereof, glutamic acid or a salt thereof, and any combination thereof.
Claim 9
Dependent Claim
21 words
A composition as claimed in claim 7 wherein in part (c) the aqueous solution used is saturated with said cross-linking agent.
Claim 10
Dependent Claim
48 words
A composition as claimed in any one of claims 1 to 5 wherein in part (c) the cross-linking is performed using an aqueous solution having therein a concentration of a cross-linking agent such that cross-linking occurs prior to the film dissolving under the action of the wetting solution.
Claim 11
Dependent Claim
74 words
A polymer composition preparable by the steps of: (a) dissolving a member selected from the group consisting of chitosan, CM-chitosan, N, CM-chitosan, N,O CM-chitosan, 0, CM-chitosan and any combination thereof in an aqueous solution; (b) drying the solution so as to form a film; and (c) forming a closed film surrounding a visco-elastic fluid by placing the film in a cross-linking bath saturated with an amino acid negatively charged at a pH of 6.
Claim 12
Dependent Claim
74 words
A polymer composition preparable by the steps of: (a) dissolving a member selected from the group consisting of chitosan, CM-chitosan, N, CM-chitosan, N,O CM-chitosan, 0, CM-chitosan and any combination thereof in an aqueous solution; (b) drying the solution so as to form a film; and (c) forming a closed film surrounding a visco-elastic fluid by placing the film in a cross-linking bath saturated with an amino acid negatively charged at a pH of 6.
Claim 13
Dependent Claim
33 words
A composition as claimed in claim 10 wherein in part (c) the amino acid is selected from aspartic acid or a salt thereof, glutamic acid or a salt thereof, and any combination thereof.
Claim 14
Dependent Claim
12 words
A composition as claimed in any preceding claim for use in medicine.
Claim 15
Dependent Claim
27 words
The use of a composition as claimed in any one of claims 1 to 11 for the manufacture of a medicament for preventing adhesion between body tissues.
Claim 16
Dependent Claim
20 words
A biodegradable derivative of chitin which is soluble in a dilute acidic aqueous solution and cross-linked for use in medicine.
Claim 17
Dependent Claim
20 words
A biodegradable derivative of chitin which is soluble in a dilute acidic aqueous solution and cross-linked for use in medicine.
Claim 18
Dependent Claim
31 words
The use of a biodegradable derivative of chitin which is soluble in a dilute acidic aqueous solution and cross-linked for the manufacture of a medicament for preventing adhesion between body tissues.
Claim 19
Dependent Claim
31 words
The use of a biodegradable derivative of chitin which is soluble in a dilute acidic aqueous solution and cross-linked for the manufacture of a medicament for preventing adhesion between body tissues.
Claim 20
Dependent Claim
63 words
A process for the preparation of a polymer composition comprising: (a) dissolving at least one biodegradable derivative of chitin in a dilute acidic aqueous solution; (b) drying the solution to form a film; (c) cross-linking the film by wetting it with an aqueous solution containing a cross-linking agent; and (d) forming a visco-elastic fluid therefrom by dissolving the film in hot aqueous solution.
Claim 21
Dependent Claim
63 words
A process for the preparation of a polymer composition comprising: (a) dissolving at least one biodegradable derivative of chitin in a dilute acidic aqueous solution; (b) drying the solution to form a film; (c) cross-linking the film by wetting it with an aqueous solution containing a cross-linking agent; and (d) forming a visco-elastic fluid therefrom by dissolving the film in hot aqueous solution.
Claim 22
Dependent Claim
76 words
A process for the preparation of a polymer composition comprising: (a) dissolving a member selected from the group consisting of chitosan, CM-chitosan, N, CM-chitosan, N,0 CM-chitosan, O, CM-chitosan and any combination thereof in an aqueous solution; (b) drying the solution so as to form a film; and (c) forming a closed film surrounding a visco-elastic fluid by placing the film in a cross-linking bath saturated with an amino acid negatively charged at a pH of 6.
Claim 23
Dependent Claim
76 words
A process for the preparation of a polymer composition comprising: (a) dissolving a member selected from the group consisting of chitosan, CM-chitosan, N, CM-chitosan, N,0 CM-chitosan, O, CM-chitosan and any combination thereof in an aqueous solution; (b) drying the solution so as to form a film; and (c) forming a closed film surrounding a visco-elastic fluid by placing the film in a cross-linking bath saturated with an amino acid negatively charged at a pH of 6.
References Cited (Backward Citations)
No citation records indexed.
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