US5773422A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Avermectin formulation
Assignee: VETERINARY RESEARCH ASSOCIATES Inc
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Filing: 1996-01-29
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Granted: 1998-06-30
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Expires: 2016-01-29
Abstract
Abstract Novel formulations are disclosed for the administration of an avermectin, based upon the use of N-methylpyrrolidone or 2-pyrrolidone or mixtures thereof to dissolve avermectin. Formulations can contain from 0.1 to 40% by weight dissolved in at least 5% by volume of N-methylpyrrolidone, 2-pyrrolidone or mixture thereof. Various formulations are suitable for administration by intramuscular or subcutaneous injection, by topical application, stomach intubation, oral and drench administration.
Inventors
- 👤 Gene Komer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7042; A61K31/7048; A61K47/00; A61K47/06; A61K47/22; A61K9/00; A61K9/0012; A61K9/0019; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
34 words
An injectable formulation for administering an avermectin comprising from 0.1% to 40% by weight of an avermectin dissolved in a solvent comprising at least 5% by volume N-methylpyrrolidone, or 2-pyrrolidone, or a mixture thereof.
Claim 2
Dependent Claim
34 words
An injectable formulation for administering an avermectin comprising from 0.1% to 40% by weight of an avermectin dissolved in a solvent comprising at least 5% by volume N-methylpyrrolidone, or 2-pyrrolidone, or a mixture thereof.
Claim 3
Dependent Claim
10 words
The formulation of claim 1 wherein the avermectin is ivermectin.
Claim 4
Dependent Claim
22 words
The formulation of claim 2 wherein the solvent is a mixture of N-methylpyrrolidone, or 2-pyrrolidone, or a mixture thereof, and propylene glycol.
Claim 5
Dependent Claim
13 words
The formulation of claim 3 further comprising up to 20% by weight polyvinylpyrrolidone.
Claim 6
Dependent Claim
25 words
The formulation of claim 2 comprising at least 10% N-methylpyrrolidone, or 2-pyrrolidone, or a mixture thereof, and further comprising up to 30% by volume water.
Claim 7
Dependent Claim
17 words
The formulation of claim 3 comprising at least 10% by volume propylene glycol, and further comprising water.
Claim 8
Dependent Claim
9 words
The formulation of claim 2 further comprising a surfactant.
Claim 9
Dependent Claim
9 words
The formulation of claim 2 further comprising a preservative.
Claim 10
Dependent Claim
8 words
The formulation of claim 2 further comprising Clorsulon.
Claim 11
Dependent Claim
14 words
The formulation of claim 2 further comprising polyethylene glycol up to 30% by weight.
Claim 12
Dependent Claim
16 words
A formulation according to claim 1 further comprising a maximum of 90% by volume propylene glycol.
Claim 13
Dependent Claim
15 words
A formulation according to claim 11 further comprising from 0.10% to 40% by weight Clorsulon.
Claim 14
Dependent Claim
16 words
A formulation according to claim 2 consisting essentially of 1% by weight ivermectin dissolved in N-methylpyrrolidone.
Claim 15
Dependent Claim
19 words
A formulation according to claim 2 consisting essentially of 1% by weight ivermectin, 70% by volume N-methylpyrrolidone, and water.
Claim 16
Dependent Claim
17 words
A formulation according to claim 6 comprising 1% by weight ivermectin, 10% by weight Clorsulon, and N-methylpyrrolidone.
Claim 17
Dependent Claim
19 words
A formulation according to claim 15 wherein the N-methylpyrrolidone is 30% by volume, the formulation further comprising propylene glycol.
Claim 18
Dependent Claim
19 words
A formulation according to claim 3 wherein the ivermectin is 10 mg/ml and the N-methylpyrrolidone is 30% by volume.
Claim 19
Dependent Claim
11 words
A formulation according to claim 17 comprising additionally 100 mg/ml Clorsulon.
Claim 20
Dependent Claim
25 words
A formulation according to claim 3 wherein ivermectin is 0.27% by weight, N-methylpyrrolidone is 40% by volume, the formulation further comprising 10% by volume water.
Claim 21
Dependent Claim
30 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 30% by volume, the formulation further comprising 1.5% by volume benzyl alcohol and 10% by volume water.
Claim 22
Dependent Claim
33 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 30% by volume, the formulation further comprising 20% by weight polyvinylpyrrolidone, 0.18% by weight methylparaben, and 0.02% by weight propylparaben.
Claim 23
Dependent Claim
25 words
A formulation according to claim 3 wherein ivermectin is 20 mg/ml, N-methylpyrrolidone is 40% by volume, the formulation further comprising 30% by weight polyethylene glycol.
Claim 24
Dependent Claim
30 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 30% by volume, the formulation further comprising 20% by weight polyvinylpyrrolidone and 1.5% by volume benzyl alcohol.
Claim 25
Dependent Claim
38 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 30% by volume, the formulation further comprising 10% by volume polysorbate 80, 10% by volume polyoxyethylene fatty acid ester and 1.5% by volume benzyl alcohol.
Claim 26
Dependent Claim
38 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 5% by volume, propylene glycol is 20% by volume, the formulation further comprising polysorbate 80 10% by volume, benzyl alcohol 1.5% by volume, and water.
Claim 27
Dependent Claim
33 words
A formulation according to claim 3 wherein ivermectin is 10 mg/ml, N-methylpyrrolidone is 20% by volume, propylene glycol is 20% by volume, the formulation further comprising 1.5% by volume benzyl alcohol, and water.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-29 | 2001-12-29 | 2002-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-29 | 2005-12-29 | 2006-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-29 | 2009-12-29 | 2010-06-30 | $7700.00 | Window Closed / Lapsed |