Cartilage repair unit

Claim 2

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a delivery unit consisting substantially of completely bio-absorbable material which is dimensionally stable against substantial expansion by absorption of synovial joint fluid and configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone; and (B) a porous insert supported by said delivery unit, consisting substantially of completely bio-absorbable material, and defining at least 95% voids by volume for establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

Claim 3

The cartilage repair system of claim 1 wherein said insert includes a repair factor releasably disposed in said insert to assist in establishing said chondrogenic growth-supporting matrix.

Claim 4

The cartilage repair system of claim 2 wherein said repair factor is a growth factor.

Claim 5

The cartilage repair system of claim 3 wherein said growth factor is selected from the group consisting of fibroblast growth factor, transforming growth factor beta, insulin, insulin-like growth factor, platelet-derived growth factor and combinations thereof.

Claim 6

The cartilage repair system of claim 2 wherein said repair factor is an attachment factor.

Claim 7

The cartilage repair system of claim 5 wherein said attachment factor is selected from the group consisting of fibronectin, RGD polypeptide and combinations thereof. selected from the group consisting of hyaluronic acid, polyglycolic acid, collagen, polylactic acid, fibrin clot, periosteal cells, polydioxane, polyester, alginate and combinations thereof.

Claim 8

The cartilage repair system of claim 1 wherein said insert consists substantially of a bio-absorbable material.

Claim 9

The cartilage repair system of claim 1 wherein said delivery unit comprises a bio-absorbable material selected from the group consisting of hyaluronic acid, polyglycolic acid, polylactic acid, alginate and combinations thereof.

Claim 10

The cartilage repair system of claim 1 wherein said delivery unit defines channels therethrough to allow vascular invasion and cellular migration to an adjacent surface of said insert.

Claim 11

The cartilage repair system of claim 1 wherein said delivery unit is integrally molded.

Claim 12

The cartilage repair system of claim 1 including means precluding relative rotation of said delivery unit and said insert in said delivery unit.

Claim 13

The cartilage repair system of claim 1 wherein said delivery unit defines channels therethrough to allow vascular invasion and cellular migration to an adjacent surface of said insert; and said assembly includes means precluding relative rotation of said delivery unit and said insert in said delivery unit.

Claim 14

The cartilage repair system of claim 12 including a plurality of assemblies, said delivery units of said assemblies being disposed within said healthy area of bone and said removed area, and said inserts of said assemblies establishing said chondrogenic growth-supporting matrix over a substantial portion of said removed area, said delivery units of said assemblies being polygonal in configuration and interfitting.

Claim 15

The cartilage repair system of claim 12 wherein said insert consists substantially of a bio-absorbable material selected from the group consisting of hyaluronic acid, polyglycolic acid, collagen, polylactic acid, fibrin clot, periosteal cells, polydioxane, polyester, alginate and combinations thereof; and said delivery unit comprises a bio-absorbable material selected from the group consisting of hyaluronic acid, polyglycolic acid, polylactic acid, alginate and combinations thereof.

Claim 16

The cartilage repair system of claim 1 wherein said delivery unit is configured as a polygon and dimensioned to be mounted in an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone.

Claim 17

The cartilage repair system of claim 12 wherein said insert includes a repair factor releasably disposed in said insert to assist in establishing said chondrogenic growth-supporting matrix, said repair factor being selected from the group consisting of a growth factor, an attachment factor and combinations thereof.

Claim 18

The cartilage repair system of claim 1 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 19

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a delivery unit consisting substantially of completely bio-absorbable material which is dimensionally stable against substantial expansion by absorption of synovial joint fluid and configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone; and (B) a porous insert supported by said delivery unit, consisting substantially of completely bio-absorbable material, and defining at least 95% voids by volume for establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix; said system including a plurality of assemblies, said delivery units of said assemblies being disposed within said bone and said removed area, and said inserts of said assemblies establishing said chondrogenic growth-supporting matrix over a substantial portion of said removed area.

Claim 20

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a delivery unit consisting substantially of completely bio-absorbable material which is dimensionally stable against substantial expansion by absorption of synovial joint fluid and configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone; and (B) a porous insert supported by said delivery unit, consisting substantially of completely bio-absorbable material, and defining at least 95% voids by volume for establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix; said system including a plurality of assemblies, said delivery units of said assemblies being disposed within said bone and said removed area, and said inserts of said assemblies establishing said chondrogenic growth-supporting matrix over a substantial portion of said removed area.

Claim 21

The cartilage repair system of claim 18 wherein said delivery units of said assemblies are polygonal in configuration and interfitting.

Claim 22

The cartilage repair system of claim 18 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 23

A cartilage repair system adapted to be mounted on a joint surface of a bone to establish a chondrogenic growth-supporting matrix, comprising a delivery unit consisting substantially of completely bio-absorbable material which is dimensionally stable against substantial expansion by absorption of synovial joint fluid and configured and dimensioned to be mounted on and within the bone, said unit including a support frame and means for mounting said unit on and within the bone, and a porous insert consisting substantially of completely bio-absorbable material, defining at least 95% voids by volume, and supported by said support frame to provide a chondrogenic growth-supporting matrix.

Claim 24

A cartilage repair system adapted to be mounted on a joint surface of a bone to establish a chondrogenic growth-supporting matrix, comprising a delivery unit consisting substantially of completely bio-absorbable material which is dimensionally stable against substantial expansion by absorption of synovial joint fluid and configured and dimensioned to be mounted on and within the bone, said unit including a support frame and means for mounting said unit on and within the bone, and a porous insert consisting substantially of completely bio-absorbable material, defining at least 95% voids by volume, and supported by said support frame to provide a chondrogenic growth-supporting matrix.

Claim 25

The cartilage repair system of claim 21 wherein said insert includes a repair factor releasably disposed in said insert to assist in providing said chondrogenic growth-supporting matrix.

Claim 26

The cartilage repair system of claim 21 wherein said support frame is constructed to allow vascular invasion and cellular migration to said insert.

Claim 27

The cartilage repair system of claim 23 wherein said support frame has an open top and a bottom defining a plurality of channels therethrough to allow vascular invasion and cellular migration to the bottom of said insert.

Claim 28

The cartilage repair system of claim 24 wherein said insert has sides, and said support frame has side walls defining windows through which said insert extends to allow cellular migration to the sides of said insert by an adjacent healthy area of articular cartilage.

Claim 29

The cartilage repair system of claim 21 wherein said unit and said insert define an assembly, and said system consists of a plurality of said assemblies in contiguous and abutting relationship.

Claim 30

The cartilage repair system of claim 21 wherein said unit is more rigid than said insert.

Claim 31

The cartilage repair system of claim 21 additionally including means precluding relative rotation of said unit and said insert.

Claim 32

The cartilage repair system of claim 21 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 33

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone, said system comprising an assembly of: (A) a bio-absorbable delivery unit configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone; and (B) a porous, bio-absorbable insert supported by said delivery unit and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix; said delivery unit having an open top, a bottom and a sidewall connecting said top and bottom, said bottom defining a plurality of channels therethrough to allow vascular invasion and cellular migration through the bottom of said insert, and said sidewall defining windows to which said insert extends to allow cellular migration to the sides of said insert by an adjacent healthy area of articular cartilage.

Claim 34

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone, said system comprising an assembly of: (A) a bio-absorbable delivery unit configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone; and (B) a porous, bio-absorbable insert supported by said delivery unit and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix; said delivery unit having an open top, a bottom and a sidewall connecting said top and bottom, said bottom defining a plurality of channels therethrough to allow vascular invasion and cellular migration through the bottom of said insert, and said sidewall defining windows to which said insert extends to allow cellular migration to the sides of said insert by an adjacent healthy area of articular cartilage.

Claim 35

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a delivery unit consisting substantially of completely bio-absorbable material to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said delivery unit including means for retaining itself in the adjacent healthy area without either an expansion of the dimensions thereof or a relative rotation thereof; and (B) a porous insert supported by said delivery unit, consisting substantially of completely bio-absorbable material, and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

Claim 36

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a delivery unit consisting substantially of completely bio-absorbable material to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said delivery unit including means for retaining itself in the adjacent healthy area without either an expansion of the dimensions thereof or a relative rotation thereof; and (B) a porous insert supported by said delivery unit, consisting substantially of completely bio-absorbable material, and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

Claim 37

The cartilage repair system of claim 31 wherein said delivery unit defines channels therethrough to allow vascular invasion and cellular migration to an adjacent surface of said insert; and said assembly includes means precluding relative rotation of said delivery unit and said insert in said delivery unit.

Claim 38

The cartilage repair system of claim 31 wherein said delivery unit comprises a platform to receive and support said insert and a plug to mount said platform relative to the adjacent healthy area, said plug including said retaining means.

Claim 39

The cartilage repair system of claim 32 wherein said insert includes a repair factor releasably disposed in said insert to assist in establishing said chondrogenic growth-supporting matrix, said repair factor being selected from the group consisting of a growth factor, an attachment factor and combinations thereof.

Claim 40

The cartilage repair system of claim 31 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 41

A cartilage repair system adapted to be mounted on a joint surface of a bone to establish a chondrogenic growth-supporting matrix, comprising a delivery unit consisting substantially of completely bio-absorbable material and configured and dimensioned to be mounted on and within the bone, said delivery unit including a support frame and means for mounting said delivery unit on and within the bone, said delivery unit including means for retaining itself in the bone without either an expansion of the dimensions thereof or a relative rotation thereof, and a porous insert consisting substantially of completely bio-absorbable material and supported by said support frame to provide a chondrogenic growth-supporting matrix.

Claim 42

A cartilage repair system adapted to be mounted on a joint surface of a bone to establish a chondrogenic growth-supporting matrix, comprising a delivery unit consisting substantially of completely bio-absorbable material and configured and dimensioned to be mounted on and within the bone, said delivery unit including a support frame and means for mounting said delivery unit on and within the bone, said delivery unit including means for retaining itself in the bone without either an expansion of the dimensions thereof or a relative rotation thereof, and a porous insert consisting substantially of completely bio-absorbable material and supported by said support frame to provide a chondrogenic growth-supporting matrix.

Claim 43

The cartilage repair system of claim 36 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 44

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a bio-absorbable delivery unit configured, as a polygon and dimensioned to be mounted in an area, of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said delivery unit including means for retaining itself in the adjacent healthy area without either an expansion of the dimensions thereof or a relative rotation thereof; and (B) a porous, bio-absorbable insert supported by said delivery unit and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

Claim 45

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a bio-absorbable delivery unit configured, as a polygon and dimensioned to be mounted in an area, of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said delivery unit including means for retaining itself in the adjacent healthy area without either an expansion of the dimensions thereof or a relative rotation thereof; and (B) a porous, bio-absorbable insert supported by said delivery unit and establishing communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

Claim 46

The cartilage repair system of claim 38 wherein said delivery unit comprises a platform to receive and support said insert and a plug to mount said platform relative to the adjacent healthy area, said plug including said retaining means.

Claim 47

The cartilage repair system of claim 38 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.

Claim 48

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a porous, bio-absorbable insert defining at least 95% voids by volume for establishing communication between a removed area and an adjacent healthy area for a chondrogenic growth-supporting matrix; and (B) a bio-absorbable delivery unit configured and dimensioned to be mounted in the removed area and the adjacent healthy area, said delivery unit including means for positioning said insert in the removed area and surrounded by the adjacent healthy area.

Claim 49

A bio-absorbable cartilage repair system for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone, said system comprising an assembly of: (A) a porous, bio-absorbable insert defining at least 95% voids by volume for establishing communication between a removed area and an adjacent healthy area for a chondrogenic growth-supporting matrix; and (B) a bio-absorbable delivery unit configured and dimensioned to be mounted in the removed area and the adjacent healthy area, said delivery unit including means for positioning said insert in the removed area and surrounded by the adjacent healthy area.

Claim 50

The cartilage repair system of claim 41 wherein said insert includes cells selected from the group consisting of isolated periosteal cells, mesenchymal stem cells, chondrocytes and combinations thereof.