Patent US5758652A successfully refreshed from Google Patents.
US5758652A
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System and method to measure the condition of a patients heart
Assignee: Telecom Medical Inc
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Filing: 1995-10-19
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Granted: 1998-06-02
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Expires: 2015-10-19
Abstract
Abstract A system and method for measuring the heart condition of a patient is disclosed. The system includes a measuring device used to generate an absolute blood pressure signal indicative of the absolute blood pressure of the patient. A processing element receives and processes the absolute blood pressure signal, and generates (1) a filtered blood pressure signal by removing certain variations from the absolute blood pressure signal caused by respiratory activity of the patient; and (2) a set of parameters derived from the filtered blood pressure signal. The set of parameters measure certain aspects of the absolute blood pressure signal which are indicative of the performance and condition of the patient's heart.
Inventors
- 👤 Serjan D. Nikolic
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 19:31
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0002; A61B5/0031; A61B5/0026; A61B5/0028; A61B5/02; A61B5/021; A61B5/0215; A61B5/72; A61B5/7235; A61B5/7239
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
162 words
A system used to measure the heart condition of a patient, the system comprising: a measuring device configured to measure absolute blood pressure of the patient and to generate an absolute blood pressure signal indicative of the absolute blood pressure of the patient during a plurality of respiratory cycles of the patient; and a processing element to process the absolute blood pressure signal, the processing element for generating a filtered blood pressure signal from the absolute blood pressure signal by substantially removing variations from the absolute blood pressure signal caused by respiratory activity of the patient during the plurality of respiratory cycles, the processing element further including a sampling element to sample the absolute blood pressure signal during a plurality of selected heart cycles that occur during the plurality of respiratory cycles and to generate a plurality of sampled blood pressure signals, and an averaging element to generate the filtered blood pressure signal by averaging the plurality of sampled blood pressure signals.
Claim 2
Independent Claim
162 words
A system used to measure the heart condition of a patient, the system comprising: a measuring device configured to measure absolute blood pressure of the patient and to generate an absolute blood pressure signal indicative of the absolute blood pressure of the patient during a plurality of respiratory cycles of the patient; and a processing element to process the absolute blood pressure signal, the processing element for generating a filtered blood pressure signal from the absolute blood pressure signal by substantially removing variations from the absolute blood pressure signal caused by respiratory activity of the patient during the plurality of respiratory cycles, the processing element further including a sampling element to sample the absolute blood pressure signal during a plurality of selected heart cycles that occur during the plurality of respiratory cycles and to generate a plurality of sampled blood pressure signals, and an averaging element to generate the filtered blood pressure signal by averaging the plurality of sampled blood pressure signals.
Claim 3
Dependent Claim
23 words
The system of claim 1, wherein the selected heart cycles occur at a selected phase of each of the plurality of respiratory cycles.
Claim 4
Dependent Claim
22 words
The system of claim 2, wherein the selected phase is an end exhalation phase of each of the plurality of respiratory cycles.
Claim 5
Dependent Claim
22 words
The system of claim 2, wherein the selected phase is an end inhalation phase of each of the plurality of respiratory cycles.
Claim 6
Dependent Claim
31 words
The system of claim 1, wherein the processing element further generates a derivative signal of the filtered blood pressure signal by performing a mathematical derivative on the filtered blood pressure signal.
Claim 7
Dependent Claim
34 words
The system of claim 1, wherein the processing element is further configured to derive one parameter from the filtered blood pressure signal that is indicative of the condition of the heart of the patient.
Claim 8
Dependent Claim
21 words
The system of claim 6, wherein the one parameter is a peak systolic pressure measurement of the filtered blood pressure signal.
Claim 9
Dependent Claim
21 words
The system of claim 6, wherein the one parameter is a minimum diastolic pressure measurement of the filtered blood pressure signal.
Claim 10
Dependent Claim
21 words
The system of claim 6, wherein the one parameter is a mean diastolic pressure measurement of the filtered blood pressure signal.
Claim 11
Dependent Claim
29 words
The system of claim 6, wherein the one parameter is a time constant of isovolumic pressure decay indicative of the rate at which the heart of the patient relaxes.
Claim 12
Dependent Claim
25 words
The system of claim 6, wherein the one parameter is a contraction signal indicative of the ability of the heart of the patient to contract.
Claim 13
Dependent Claim
36 words
The system of claim 11, wherein the processing element is configured to generate the contraction signal by determining a change in blood pressure over time during an isovolumic contraction phase of the filtered blood pressure signal.
Claim 14
Dependent Claim
63 words
The system of claim 11, wherein the contraction signal includes one of the following group of measurements derived from the filtered blood pressure signal, the group including the measurements of (a) a maximum pressure time derivative; (b) a normalized maximum pressure time derivative; (c) a time to the maximum pressure time derivative; and (e) a normalized time to the maximum pressure time derivative.
Claim 15
Dependent Claim
25 words
The system of claim 6, wherein the one parameter is a relaxation signal indicative of the ability of the heart of the patient to relax.
Claim 16
Dependent Claim
32 words
The system of claim 14, wherein the processing element generates the relaxation signal by calculating a change in pressure over time during an isovolumic relaxation phase of the filtered blood pressure signal.
Claim 17
Dependent Claim
95 words
The system of claim 14, wherein the relaxation signal includes one of the following group of measurements which are derived from the filtered blood pressure signal, the group including the measurements of (a) a minimum pressure time derivative; (b) a time to the minimum pressure time derivative; (c) the value of the filtered blood pressure signal at the time to the minimum pressure time derivative; (d) a minimum value of the second derivative; and (e) the blood pressure at a predetermined point in the down slope of the second derivative of the filtered blood signal.
Claim 18
Dependent Claim
30 words
The system of claim 6, wherein the one parameter includes at least one of the following measurements: (a) end diastolic pressure; and (b) a time to the end diastolic pressure.
Claim 19
Dependent Claim
23 words
The system of claim 6, wherein the one parameter is a time measurement of a diastolic period of the filtered blood pressure signal.
Claim 20
Dependent Claim
27 words
The system of claim 6, wherein the one parameter is a measure of an asymptote of isovolumic relaxation pressure exponential derived from the filtered blood pressure signal.
Claim 21
Dependent Claim
19 words
The system of claim 6, wherein the one parameter is a measure of the heart rate of the patient.
Claim 22
Dependent Claim
66 words
The system of claim 1, wherein the processing element is an implantable device designed to be implanted into the body of the patient and includes digital circuitry configured to process the absolute blood pressure signal and to generate the filtered blood pressure signal by removing certain variations from the absolute blood pressure signal due to respiratory activity of the patient during the plurality of respiratory cycles.
Claim 23
Dependent Claim
67 words
The system of claim 1, wherein the processing element is an implantable device designed to be surgically implanted into the body of the patient and includes analog circuitry configured to process the absolute blood pressure signal and to generate the filtered blood pressure signal by removing certain variations from the absolute blood pressure signal due to respiratory activity of the patient during the plurality of respiratory cycles.
Claim 24
Dependent Claim
38 words
The system of claim 1, wherein the measuring device is configured to be implanted in a chamber of the patient's heart and is configured to measure the absolute blood pressure flowing through the chamber of the patient's heart.
Claim 25
Dependent Claim
18 words
The system of claim 1, wherein the measuring device and the processing unit are integrated into a housing.
Claim 26
Dependent Claim
19 words
The system of claim 24, wherein the housing is intended to be implanted into the heart of the patient.
Claim 27
Independent Claim
167 words
A method to analyze the heart condition of a patient, comprising the steps of: measuring absolute blood pressure of the patient during a plurality of respiratory cycles of the patient; generating an absolute blood pressure signal indicative of the absolute blood pressure of the patient during the plurality of respiratory cycles of the patient; generating a filtered blood pressure signal from the absolute blood pressure signal by substantially removing variations from the absolute blood pressure signal caused by respiratory activity of the patient during the plurality of respiratory cycles; the step of generating the filtered blood pressure signal further including the steps of: sampling the absolute blood pressure signal during each of a plurality of selected heart cycles that occur over course of the plurality of respiratory cycles; generating sampled blood pressure signals: averaging the sampled blood pressure signals; generating the filtered blood pressure signal from the averaged sampled blood pressure signals; and analyzing the condition of the patient's heart based on the filtered blood pressure signal.
Claim 28
Independent Claim
167 words
A method to analyze the heart condition of a patient, comprising the steps of: measuring absolute blood pressure of the patient during a plurality of respiratory cycles of the patient; generating an absolute blood pressure signal indicative of the absolute blood pressure of the patient during the plurality of respiratory cycles of the patient; generating a filtered blood pressure signal from the absolute blood pressure signal by substantially removing variations from the absolute blood pressure signal caused by respiratory activity of the patient during the plurality of respiratory cycles; the step of generating the filtered blood pressure signal further including the steps of: sampling the absolute blood pressure signal during each of a plurality of selected heart cycles that occur over course of the plurality of respiratory cycles; generating sampled blood pressure signals: averaging the sampled blood pressure signals; generating the filtered blood pressure signal from the averaged sampled blood pressure signals; and analyzing the condition of the patient's heart based on the filtered blood pressure signal.
Claim 29
Dependent Claim
22 words
The method of claim 26, wherein the sampling step occurs at the same phase of each of the plurality of respiratory cycles.
Claim 30
Dependent Claim
23 words
The method of claim 27, wherein the sampling step occurs at an end exhalation phase of each of the plurality of respiratory cycles.
Claim 31
Dependent Claim
23 words
The method of claim 27, wherein the sampling step occurs at an end inhalation phase of each of the plurality of respiratory cycles.
Claim 32
Dependent Claim
35 words
The method of claim 26, wherein the processing step further comprises the step of generating a derivative signal of the filtered blood pressure signal by performing a mathematical derivative on the filtered blood pressure signal.
Claim 33
Dependent Claim
35 words
The method of claim 25, wherein the processing step further comprises the step of deriving one parameter from the filtered blood pressure signal that is indicative of the condition of the heart of the patient.
Claim 34
Dependent Claim
29 words
The method of claim 31, wherein the step of deriving the one parameter comprises the step of deriving a peak systolic pressure measurement of the filtered blood pressure signal.
Claim 35
Dependent Claim
29 words
The method of claim 31, wherein the step of deriving the one parameter comprises the step of deriving a minimum diastolic pressure measurement of the filtered blood pressure signal.
Claim 36
Dependent Claim
29 words
The method of claim 31, wherein the step of deriving the one parameter comprises the step of deriving a mean diastolic pressure measurement of the filtered blood pressure signal.
Claim 37
Dependent Claim
37 words
The method of claim 31, wherein the step of deriving the one parameter comprises the step of deriving a time constant of isovolumic pressure decay indicative of the rate at which the heart of the patient relaxes.
Claim 38
Dependent Claim
33 words
The method of claim 31, wherein the step of deriving the one parameter comprises the step of deriving a contraction signal indicative of the ability of the heart of the patient to contract.
Claim 39
Dependent Claim
37 words
The method of claim 36, wherein the step of generating the contraction signal further includes the step of measuring a change in blood pressure over time during an isovolumic contraction phase of the filtered blood pressure signal.
Claim 40
Dependent Claim
61 words
The method of claim 36, further comprising the step of generating at least one of the following measurements after the step of deriving the contraction signal, measurements including (a) a maximum pressure time derivative; (b) a normalized maximum pressure time derivative; (c) a time to the maximum pressure time derivative; and (e) a normalized time to the maximum pressure time derivative.
Claim 41
Dependent Claim
32 words
The method of claim 31, wherein the step of deriving one parameter comprises the step of deriving a relaxation signal indicative of the ability of the heart of the patient to relax.
Claim 42
Dependent Claim
36 words
The method of claim 31, wherein the step of generating the relaxation signal further includes the step of calculating a change in pressure over time during an isovolumic relaxation phase of the filtered blood pressure signal.
Claim 43
Dependent Claim
86 words
The method of claim 40, wherein the step of generating the relaxation signal includes at least one of the following steps of generating (a) a minimum pressure time derivative; (b) a time to the minimum pressure time derivative; (c) the value of the filtered blood pressure signal at the time to the minimum pressure time derivative; (d) a minimum value of the second derivative; and (e) the blood pressure at a predetermined point in the down slope of the second derivative of the filtered blood signal.
Claim 44
Dependent Claim
38 words
The method of claim 31, wherein the step of generating the one parameter includes the step of generating at least one of the following measurements: (a) end diastolic pressure; and (b) a time to the end diastolic pressure.
Claim 45
Dependent Claim
31 words
The method of claim 31, wherein the step of generating the one parameter includes the step of generating a time measurement of a diastolic period of the filtered blood pressure signal.
Claim 46
Dependent Claim
36 words
The method of claim 31, wherein the step of generating the one parameter further includes the step of generating a measure of an asymptote of isovolumic relaxation pressure exponential derived from the filtered blood pressure signal.
Claim 47
Dependent Claim
32 words
The method of claim 31, wherein the step of generating the one parameter further includes the step of generating a signal indicative of a measure of the heart rate of the patient.
Claim 48
Dependent Claim
30 words
The method of claim 25, further comprising the step of subscribing a medical treatment for the patient, if needed, based on the step of measuring the condition of the patient.
Claim 49
Dependent Claim
140 words
The method of claim 46, wherein the step of measuring the patient's heart further comprising the steps of: generating a set of parameters from the filtered blood pressure signal, each one of the set of parameters providing a measure of a particular function of the heart cycle of the patient at a first point in time; generating a second set of parameters from a second filtered blood pressure signal, each one of the second set of parameters providing a measure of a particular function of the heart cycle of the patient at a second point in time; comparing the first set of parameters and the second set of parameters; and determining the relative differences between the first set of parameters generated at the first point in time and the second set of parameters generated at the second point in time.
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